Chamomile for Anxiety-Related Sleep Problems

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

Based on 4 studies (2 meta-analyses). 3/4 studies show positive effects.

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The Bottom Line

Chamomile may help improve sleep when anxiety is keeping you awake, with most studies showing positive effects through its calming GABA-related activity.

3 out of 4 studies show positive effects, including 2 meta-analyses
Works through GABA-modulating pathways that promote relaxation
Has a long traditional history of use as a calming bedtime tea
Grade B evidence — promising but would benefit from additional clinical trials

Key Study Findings

Meta-Analysis

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.

Dose: Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion vs: Placebo Effect: Silexan MD -3.84 (95% CrI -6.31 to -1.34); Kava MD -2.46 (95% CrI -4.47 to -0.32); Ginkgo biloba MD None

Review

Safety and efficacy of herbal sedatives in cancer care.

Dose: None vs: Placebo Effect: None None

Key Statistics

Studies

Participants

↑

Positive

Grade

Referenced Papers

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis

Pharmacological research 2022 51 citations

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 citations

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 citations

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

sleep:: 270-400 mg extract or 1-3 cups tea

Upper limit: Not established

Dosages Studied in Research

Dosage	Duration	Effect	N
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion	--	Positive	--
None	--	Positive	--

Best taken: 30-60 minutes before bed

Safety & Side Effects

Reported Side Effects

⚠ Allergic reactions (ragweed family)
⚠ Nausea
⚠ Drowsiness

Known Interactions

● Blood thinners (warfarin) — chamomile contains coumarin compounds
● CYP1A2 substrates — chamomile may inhibit this enzyme
● Sedatives — mild additive effects

Tolerable upper intake: Not established

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Chamomile help with Anxiety-Related Sleep Problems?

Based on 4 studies with 0 participants, there is moderate evidence from clinical studies that Chamomile may support Anxiety-Related Sleep Problems management. Our evidence grade is B (Good Evidence).

How much Chamomile should I take for Anxiety-Related Sleep Problems?

Studies have used various dosages. A commonly studied range is 270-400 mg extract or 1-3 cups tea. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Chamomile?

Reported side effects may include Allergic reactions (ragweed family), Nausea, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Chamomile and Anxiety-Related Sleep Problems?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.

Chamomile for other conditions

Insomnia A

Quick Verdict

Based on 4 studies (2 meta-analyses). 3/4 studies show positive effects.

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (1)Other (3)

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References

[1] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
[2] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed
[3] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
[4] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.