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Phosphatidylserine for Anxiety-Related Sleep Problems

D

Based on 2 studies. Results are mixed across studies.

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The Bottom Line

            
            
There is not enough evidence to determine whether phosphatidylserine helps with anxiety-related sleep problems — the research is too early-stage to draw conclusions.

            
            
            
    
                
                
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                    Only 2 studies available with no reported participant data
                
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                    No human clinical trials or RCTs specifically on this use
                
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                    Theoretical basis exists through stress hormone regulation pathways
                
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                    Much more research is needed before making any recommendations
                
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Key Study Findings





    

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
            
            

                
                Dose: L. plantarum JGR2 serial passages
                
                
                vs: Ancestral strain
                
                
                Outcome: Phenotypic and genomic changes
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: In vitro bacterial culture study

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Genomic analysis of Burkholderia sp. ISTR5 for biofunneling of lignin-derived compounds.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Studies

    

    

        
--

        
Participants

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        D

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of applied …
                        2024
                        
                        1 citations
                        
                    

                

                
                

                    

                        
                            Genomic analysis of Burkholderia sp. ISTR5 for biofunneling of lignin-derived compounds.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Biotechnology for biofuels
                        2019
                        
                        57 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
sleep:

                        
100-300 mg, evening

                    

                    
                

                
                

                    Upper limit: Not established; studied up to 600 mg/day
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                L. plantarum JGR2 serial passages
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
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                                    Positive
                                    
                                
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                Best taken: With dinner or 1-2 hours before bed
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            Insomnia at high doses (paradoxical)
                        
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                            GI upset
                        
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                            Nausea
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            Blood thinners — phosphatidylserine may have mild anticoagulant effects
                        
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                            Anticholinergic drugs — may affect cholinergic signaling
                        
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                            Alzheimer's medications (cholinesterase inhibitors) — potential interaction
                        
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                        Tolerable upper intake: Not established; studied up to 600 mg/day
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Phosphatidylserine help with Anxiety-Related Sleep Problems?
            
        
        

            Based on 2 studies with 0 participants, there is preliminary evidence that needs more research that Phosphatidylserine may support Anxiety-Related Sleep Problems management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much Phosphatidylserine should I take for Anxiety-Related Sleep Problems?
            
        
        

            Studies have used various dosages. A commonly studied range is 100-300 mg, evening. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Phosphatidylserine?
            
        
        

            Reported side effects may include Insomnia at high doses (paradoxical), GI upset, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Phosphatidylserine and Anxiety-Related Sleep Problems?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 0 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.