Conditions

14 health conditions with evidence-based supplement research

We evaluate supplements across specific sleep-related conditions. Each condition page ranks ingredients by evidence grade, showing you what the research says about supplements for insomnia, restless sleep, and more.

How We Grade Evidence

Each condition page ranks supplement ingredients by the strength of clinical evidence. Here is what each grade means:

Strong Evidence

Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.

Good Evidence

At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.

Some Evidence

Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.

Very Early Research

In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.

Age-Related Sleep Changes

Affects majority of adults over 60

Earlier wake times Less deep sleep More frequent awakenings +1

Anxiety-Related Sleep Problems

70-80% of anxiety disorder patients report sleep problems

Pre-sleep worry Hypervigilance Somatic tension +1

Circadian Rhythm Disorder

0.13-0.17% delayed sleep phase; higher in adolescents

Inability to sleep at desired time Excessive sleepiness Social/work impairment

Hyperarousal and Cognitive Insomnia

Central feature in 50-70% of chronic insomnia cases

Racing thoughts at bedtime Inability to 'turn off' the mind Heightened alertness in bed +1

Insomnia

10-15% chronic insomnia; 30-35% occasional symptoms

Difficulty falling asleep Frequent awakenings Early morning waking +1

Jet Lag

Affects most transmeridian travelers (>3 time zones)

Insomnia at destination bedtime Daytime fatigue GI disturbance +1

Menopause-Related Sleep Disturbance

40-60% of perimenopausal and postmenopausal women

Hot flashes disrupting sleep Night sweats Difficulty returning to sleep +1

Nighttime Pain-Related Sleep Disruption

50-80% of chronic pain patients report sleep disruption

Difficulty finding comfortable position Frequent awakenings from pain Unrefreshing sleep +1

Pregnancy-Related Sleep Disruption

75-90% of pregnant women report sleep problems, especially in third trimester

Frequent urination at night Difficulty finding comfortable position Leg cramps +1

Restless Leg Syndrome

5-10% of adults; 2-3% have clinically significant symptoms

Urge to move legs Creeping/crawling sensations Evening worsening +1

Shift Work Sleep Disorder

10-38% of shift workers

Insomnia during day sleep Excessive sleepiness at work Reduced total sleep time

Sleep Apnea

9-38% of general population; higher with obesity

Loud snoring Witnessed apneas Excessive daytime sleepiness +1

Sleep Maintenance Insomnia

More common in older adults; affects ~15% of population

Multiple night awakenings Difficulty returning to sleep Light sleep +1

Sleep Onset Difficulty

15-20% of adults report difficulty falling asleep

Lying awake >30 min Racing thoughts Physical tension +1

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.