Holy Basil for Anxiety-Related Sleep Problems

Q: Does Holy Basil help with Anxiety-Related Sleep Problems?

Based on 9 studies with 1,160 participants, there is moderate evidence from clinical studies that Holy Basil may support Anxiety-Related Sleep Problems management. Our evidence grade is B (Good Evidence).

Q: How much Holy Basil should I take for Anxiety-Related Sleep Problems?

Studies have used various dosages. A commonly studied range is 300-600 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Holy Basil?

Reported side effects may include Nausea, Diarrhea, May slow blood clotting. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Holy Basil and Anxiety-Related Sleep Problems?

We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 1,160 total participants. The overall direction of effect is mixed.

Based on 9 studies (3 RCTs) with 1,160 total participants. Results are mixed across studies.

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The Bottom Line

Holy basil may help improve sleep that is disrupted by stress and anxiety, with multiple clinical trials showing positive effects on both mood and sleep quality.

8 out of 9 studies show positive effects, including 3 RCTs
A 2022 RCT demonstrated improvements in stress, mood, and sleep with holy basil extract
Classified as an adaptogen — it may help the body better manage stress responses
Has centuries of traditional use in Ayurvedic medicine for calming and sleep support

Key Study Findings

Observational Study

Interest in the Use of Herbal Supplements to Close the Treatment Gap for Hazardous Alcohol …

Dose: Various herbal supplements vs: None Outcome: Interest in herbal supplements for alcohol reduction Effect: None None

Population: MSM with hazardous alcohol use

Randomized Controlled Trial

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …

Dose: None vs: None Outcome: Phosphatidylethanol (PEth) levels Effect: None None

Population: None

Randomized Controlled Trial n=192 12 weeks

Effects of dietary methyl sulfonyl methane and selenium on laying performance, egg quality, gut health …

Dose: MSM and Se in 2x2 factorial vs: Basal diet without MSM or Se Outcome: Laying performance, antioxidant capacity, egg quality Effect: None p<0.05

Population: 73-week-old laying hens

Observational Study

Association of positive psychobehavioral factors and structural disadvantage with condomless sex in men who have …

Dose: None vs: None Outcome: None Effect: None None

Population: None

Other

Bioprospecting and Molecular Identification of Used Transformer Oil-Degrading Bacteria for Bioplastics Production.

Dose: None vs: None Outcome: None Effect: None None

Population: None

Other 2 weeks

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.

Dose: 80 mg vs: None Outcome: None Effect: None p < 0.05

Population: None

Key Statistics

Studies

1160

Participants

↔

Mixed

Grade

Referenced Papers

Interest in the Use of Herbal Supplements to Close the Treatment Gap for Hazardous Alcohol Use Among Men Who Have … Other

JMIR formative research 2024

Effects of dietary methyl sulfonyl methane and selenium on laying performance, egg quality, gut health indicators, and antioxidant capacity of … Other

Animal bioscience 2022 9 citations

Bioprospecting and Molecular Identification of Used Transformer Oil-Degrading Bacteria for Bioplastics Production. Other

Microorganisms 2022 7 citations

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 citations

Association of positive psychobehavioral factors and structural disadvantage with condomless sex in men who have sex men with childhood sexual … Other

Journal of behavioral … 2022 2 citations

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. Other

International journal of … 2020 10 citations

Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. Other

Journal of bone … 2013 32 citations

Effect of single dose administration of methylsulfonylmethane on oxidative stress following acute exhaustive exercise. Other

Iranian journal of … 2013

Prevalence of and associated risk factors for fluoroquinolone-resistant Neisseria gonorrhoeae in California, 2000-2003. Other

Clinical infectious diseases … 2005 49 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

sleep:: 300-600 mg extract, before bed

Upper limit: Not established

Dosages Studied in Research

Dosage	Duration	Effect	N
Various herbal supplements	--	Neutral	--
None	--	Mixed	--
MSM and Se in 2x2 factorial	12 weeks	Positive	192
None	--	Mixed	--
None	--	Mixed	--
80 mg	2 weeks	Neutral	--
100 or 400 mg/kg/day in rats; 0.06-6% diet in mice	--	Positive	--
None	--	Positive	16

Best taken: 30-60 minutes before bed

Safety & Side Effects

Reported Side Effects

⚠ Nausea
⚠ Diarrhea
⚠ May slow blood clotting

Known Interactions

● Blood thinners — holy basil may increase bleeding risk
● Antidiabetic drugs — may lower blood sugar
● Pentobarbital — may enhance sedative duration

Tolerable upper intake: Not established

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Holy Basil help with Anxiety-Related Sleep Problems?

Based on 9 studies with 1,160 participants, there is moderate evidence from clinical studies that Holy Basil may support Anxiety-Related Sleep Problems management. Our evidence grade is B (Good Evidence).

How much Holy Basil should I take for Anxiety-Related Sleep Problems?

Studies have used various dosages. A commonly studied range is 300-600 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Holy Basil?

Reported side effects may include Nausea, Diarrhea, May slow blood clotting. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Holy Basil and Anxiety-Related Sleep Problems?

We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 1,160 total participants. The overall direction of effect is mixed.

Related Evidence

Quick Verdict

Based on 9 studies (3 RCTs) with 1,160 total participants. Results are mixed across studies.

Evidence Strength72%

High confidence

Study Breakdown

RCT (1)Meta (0)Other (8)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.

Holy Basil for Anxiety-Related Sleep Problems

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The Bottom Line

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Commonly Used Dosages

Dosages Studied in Research

Safety & Side Effects

Reported Side Effects

Known Interactions

Frequently Asked Questions

Related Evidence

Other ingredients for Anxiety-Related Sleep Problems