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SleepCited

California Poppy for Anxiety-Related Sleep Problems

D Early Research Only preliminary research exists (lab studies, case reports).

Based on 2 studies with 40 total participants. Results are mixed across studies.

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            D

        

        

            
The Bottom Line

            
            
Based on 2 studies with 40 total participants. Results are mixed across studies.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    prospective single-arm open-label pilot study
                
                
                n=40
                
                
                4 weeks
                
                
                Open-label
                
            

            
                A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …
            
            

                
                Dose: not specified per component
                
                
                vs: Placebo
                
                
                
                Effect: mean sleep quality +1.9 points
                
                
                p < 0.001
                
            

            
        

        
        

            

                
                    review
                
                
                
                
            

            
                Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
            
            

                
                Dose: various (passionflower, valerian, chamomile, melatonin, kava, etc.)
                
                
                vs: Placebo
                
                
                
                Effect: None
                
                
                None
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Studies

    

    

        
40

        
Participants

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        D

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Complementary therapies in …
                        2019
                        
                        26 citations
                        
                    

                

                
                

                    

                        
                            Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2005
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
sleep:

                        
300-600 mg dried herb extract, 30-60 min before bed

                    

                    
                

                
                

                    Upper limit: Not formally established
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                not specified per component
                                4 weeks
                                
                                    
                                    Positive
                                    
                                
                                40
                            

                            
                            

                                various (passionflower, valerian, chamomile, melatonin, kava, etc.)
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: 30-60 minutes before bed
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Drowsiness (intended effect)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild diuretic effect
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential interaction with drug testing (may cause false positives for opiates, though rare)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Sedatives and anxiolytics — additive CNS depression
                        
    • 
                        
                        
  • 
                            ●
                            MAO inhibitors — theoretical COMT inhibition interaction
                        
    • 
                        
                        
  • 
                            ●
                            Opioid medications — may potentiate or interfere with opioid effects
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does California Poppy help with Anxiety-Related Sleep Problems?
            
        
        

            Based on 2 studies with 40 participants, there is preliminary evidence that needs more research that California Poppy may support Anxiety-Related Sleep Problems management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much California Poppy should I take for Anxiety-Related Sleep Problems?
            
        
        

            Studies have used various dosages. A commonly studied range is 300-600 mg dried herb extract, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of California Poppy?
            
        
        

            Reported side effects may include Drowsiness (intended effect), Mild diuretic effect, Potential interaction with drug testing (may cause false positives for opiates, though rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for California Poppy and Anxiety-Related Sleep Problems?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 40 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
California Poppy for other conditions

                    

                        
                        
                            Sleep Onset Difficulty
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Patrick Lemoine et al..
      Complement Ther Med.
      2019.
      A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
      doi:10.1016/j.ctim.2019.05.024
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Amy Lynn Meolie et al..
      J Clin Sleep Med.
      2005.
      Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
      
      PubMed
    
    3. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.