维生素 D 用于失眠

基于53项研究（3项荟萃分析、1项RCT），共685,942名参与者。各研究结果不一。

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结论

The evidence on vitamin D for insomnia is mixed — low vitamin D levels are associated with poor sleep, but taking vitamin D supplements does not consistently improve insomnia symptoms.

53 studies with 685,942 participants, though mostly from observational research
Low vitamin D levels are associated with poor sleep in population studies
Supplementation results are inconsistent — not a reliable standalone sleep aid
May be most relevant for people who are vitamin D deficient

Key Study Findings

review

Vitamin D and Sleep Disorders.

Dose: None vs: Placebo 效果: None None

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None vs: Placebo 效果: None None

review

Nutritional Supplements for Healthy Aging: A Critical Analysis Review.

Dose: None vs: Placebo 效果: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo 效果: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo 效果: None None

systematic review and meta-analysis

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.

Dose: None vs: Placebo 效果: None None

Key Statistics

研究数量

685966

受试者

↔

Mixed

等级

Referenced Papers

Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia. Other

The Journal of … 2026

Vitamin D and Sleep Disorders. Review

Advances in experimental … 2026

Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study. Other

Child psychiatry and … 2025 6 次引用

Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

American journal of … 2025 6 次引用

Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other

Clinical nutrition ESPEN 2025 1 次引用

Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other

Journal of physiological … 2025 1 次引用

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review

Frontiers in neurology 2025 1 次引用

The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other

Frontiers in neurology 2025 1 次引用

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other

Research square 2025

A multimodal data-based diagnostic model for predicting vestibular migraine: a retrospective study. Other

Frontiers in neurology 2025

Risperidone-Induced Paradoxical Agitation in a Child With Lamb-Shaffer Syndrome, Autism Spectrum Disorder, and Attention Deficit Hyperactivity Disorder: A Case Report. Case Report

Cureus 2025

Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study. Other

Medicine 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review. Case Report

Frontiers in toxicology 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Corrigendum: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2025

Beyond bone health: mental and sleep health consequences of vitamin D deficiency in emerging adulthood-findings from a large-scale university study. Other

Psychology, health & … 2025

Top studies of 2024 relevant to primary care: From the PEER team. Review

Canadian family physician … 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia. Case Report

Cureus 2024 2 次引用

A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases. Review

Neuroimmunomodulation 2024 2 次引用

Clinical and genetic associations for night eating syndrome in a patient biobank. Other

Journal of eating … 2024 1 次引用

Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. Other

BMC neurology 2024 1 次引用

Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study. Other

Nature and science … 2024 1 次引用

[Advances in Mendelian randomization studies on autism spectrum disorder]. Review

Zhongguo dang dai … 2024

Commentary: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2024

Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis

Psychiatry and clinical … 2023 67 次引用

Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other

International journal of … 2023 19 次引用

Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other

The Journal of … 2023 9 次引用

Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review

Current oncology reports 2023 5 次引用

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 次引用

Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report

Frontiers in neurology 2023 3 次引用

The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other

Frontiers in nutrition 2023 3 次引用

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other

Heliyon 2023 3 次引用

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 次引用

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety. Other

Human brain mapping 2023

Digital Addiction and Sleep. Review

International journal of … 2022 107 次引用

The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review

International journal of … 2022 36 次引用

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 次引用

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 次引用

Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review. Systematic Review

Pharmacological research 2022 9 次引用

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 次引用

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 次引用

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 次引用

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 次引用

Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Other

Sleep medicine: X 2022 2 次引用

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. Other

International journal of … 2021 25 次引用

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 次引用

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 次引用

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other

Sleep medicine: X 2021 9 次引用

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other

Basic and clinical … 2021 2 次引用

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 次引用

Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other

Diabetes care 2020 110 次引用

Quality of life of patients more than 1 year after surgery for thyroid cancer. Other

Hormones (Athens, Greece) 2020 20 次引用

Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other

Food science & … 2020 17 次引用

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 次引用

Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other

Journal of the … 2019 58 次引用

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 次引用

Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other

Acta neurologica Scandinavica 2019 36 次引用

Association between Vitamin D Status and Premenstrual Symptoms. Other

Journal of the … 2019 16 次引用

Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other

PloS one 2018 69 次引用

Complement systems C4, C3 and CH50 not subject to a circadian rhythm. Other

Diagnosis (Berlin, Germany) 2018 4 次引用

Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. Other

Clinica chimica acta; … 2017 14 次引用

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … Other

Medical hypotheses 2016 105 次引用

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 次引用

Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults. Other

PloS one 2015 35 次引用

Effects of a phyto complex on well-being of climacteric women. Observational

The journal of … 2015 13 次引用

Viscum album (mistletoe) for pancreatic cancer, electromagnetic field therapy for osteoarthritis, homeopathy for multidrug-resistant tuberculosis, vitamin D for depression, acupuncture … Other

Explore (New York, … 2015 7 次引用

Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia? Other

Breast cancer research … 2015

Sleep symptoms associated with intake of specific dietary nutrients. Other

Journal of sleep … 2014 236 次引用

Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. Other

PloS one 2014 106 次引用

Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial. RCT

BMJ (Clinical research … 2014 8 次引用

[Psychotic disorder induced by Fahr's syndrome: a case report]. Case Report

L'Encephale 2014 7 次引用

Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Other

Journal of child … 2013 18 次引用

Occurrence of milnacipran-associated morbilliform rash and serotonin toxicity. Case Report

The Annals of … 2013

Outcomes in older versus younger patients over 96 weeks in HIV-1- infected patients treated with rilpivirine or efavirenz in ECHO … RCT

Current HIV research 2013

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 次引用

Intensive session: New approaches to medical issues in long-term care. Review

Journal of the … 2007

Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Other

Cancer biotherapy & … 2006 29 次引用

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Sleep behavior disorders in a large cohort of chinese (Taiwanese) patients maintained by long-term hemodialysis. Other

American journal of … 2006

[Hypoparathyroidism associated with systemic lupus erythematosus: a case]. Case Report

Annales d'endocrinologie 2006

Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. Other

Medicine and science … 2005

Endometrial effects during hormone replacement therapy with a sequential oestradiol valerate/cyproterone acetate preparation. RCT

Maturitas 1993

Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. Other

Acta psychiatrica Scandinavica 1979 22 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 600-800 IU/day
deficiency:: 1,000-5,000 IU/day

上限： 4,000 IU/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

最佳服用时间： Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

已报告的副作用

⚠ Hypercalcemia at high doses
⚠ Nausea
⚠ Constipation
⚠ Kidney stones (rare, with excessive intake)

已知相互作用

● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
● Statins — vitamin D may affect statin metabolism

可耐受最高摄入量： 4,000 IU/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 维生素 D help with 失眠?

Based on 56 studies with 685,966 participants, there is strong evidence from multiple clinical trials that 维生素 D may support 失眠 management. Our evidence grade is A (Strong Evidence).

How much 维生素 D should I take for 失眠?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 维生素 D?

Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 维生素 D and 失眠?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 56 peer-reviewed studies with 685,966 total participants. The overall direction of effect is mixed.

Related Evidence

其他成分用于失眠

褪黑素（Melatonin） A 缬草根 A CBD（大麻二酚） A Omega-3 脂肪酸 A 色氨酸（Tryptophan） A 薰衣草 A

维生素 D 用于其他健康状况

睡眠维持性失眠 D

快速结论

基于53项研究（3项荟萃分析、1项RCT），共685,942名参与者。各研究结果不一。

Evidence Strength92%

High confidence

研究分析

RCT (5)Meta (1)Other (50)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于失眠

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。

维生素 D 用于 失眠

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结论

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

常用剂量

研究中使用的剂量

Safety & Side Effects

已报告的副作用

已知相互作用

Frequently Asked Questions

Related Evidence

其他成分用于 失眠

维生素 D 用于其他健康状况

维生素 D 用于失眠

其他成分用于失眠