Vitamin D for Insomnia

Based on 56 studies (3 meta-analyses, 1 RCT) with 685,966 total participants. Results are mixed across studies.

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The Bottom Line

The evidence on vitamin D for insomnia is mixed — low vitamin D levels are associated with poor sleep, but taking vitamin D supplements does not consistently improve insomnia symptoms.

53 studies with 685,942 participants, though mostly from observational research
Low vitamin D levels are associated with poor sleep in population studies
Supplementation results are inconsistent — not a reliable standalone sleep aid
May be most relevant for people who are vitamin D deficient

Key Study Findings

review

Vitamin D and Sleep Disorders.

Dose: None vs: Placebo Effect: None None

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None vs: Placebo Effect: None None

review

Nutritional Supplements for Healthy Aging: A Critical Analysis Review.

Dose: None vs: Placebo Effect: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Effect: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Effect: None None

systematic review and meta-analysis

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.

Dose: None vs: Placebo Effect: None None

Key Statistics

Studies

685966

Participants

↔

Mixed

Grade

Referenced Papers

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Vitamin D and Sleep Disorders. Review

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Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study. Other

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Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

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Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other

Clinical nutrition ESPEN 2025 1 citations

Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other

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Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review

Frontiers in neurology 2025 1 citations

The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other

Frontiers in neurology 2025 1 citations

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

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[Nutrition in improving sleep quality and fighting insomnia]. Review

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Corrigendum: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2025

Beyond bone health: mental and sleep health consequences of vitamin D deficiency in emerging adulthood-findings from a large-scale university study. Other

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Top studies of 2024 relevant to primary care: From the PEER team. Review

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Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

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[Advances in Mendelian randomization studies on autism spectrum disorder]. Review

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Commentary: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2024

Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis

Psychiatry and clinical … 2023 67 citations

Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other

International journal of … 2023 19 citations

Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other

The Journal of … 2023 9 citations

Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review

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Complementary and Integrative Approaches to Sleep Disorders in Children. Review

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Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report

Frontiers in neurology 2023 3 citations

The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other

Frontiers in nutrition 2023 3 citations

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other

Heliyon 2023 3 citations

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 citations

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American family physician 2023

Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety. Other

Human brain mapping 2023

Digital Addiction and Sleep. Review

International journal of … 2022 107 citations

The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review

International journal of … 2022 36 citations

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 citations

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 citations

Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review. Systematic Review

Pharmacological research 2022 9 citations

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 citations

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 citations

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 citations

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 citations

Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Other

Sleep medicine: X 2022 2 citations

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. Other

International journal of … 2021 25 citations

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 citations

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 citations

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other

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High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other

Basic and clinical … 2021 2 citations

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

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Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other

Diabetes care 2020 110 citations

Quality of life of patients more than 1 year after surgery for thyroid cancer. Other

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Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other

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The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

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Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other

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Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

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Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other

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Association between Vitamin D Status and Premenstrual Symptoms. Other

Journal of the … 2019 16 citations

Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other

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Complement systems C4, C3 and CH50 not subject to a circadian rhythm. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:: 600-800 IU/day
deficiency:: 1,000-5,000 IU/day

Upper limit: 4,000 IU/day

Dosages Studied in Research

Dosage	Duration	Effect	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

Best taken: Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

Reported Side Effects

⚠ Hypercalcemia at high doses
⚠ Nausea
⚠ Constipation
⚠ Kidney stones (rare, with excessive intake)

Known Interactions

● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
● Statins — vitamin D may affect statin metabolism

Tolerable upper intake: 4,000 IU/day

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Vitamin D help with Insomnia?

Based on 56 studies with 685,966 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Insomnia management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Insomnia?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Insomnia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 56 peer-reviewed studies with 685,966 total participants. The overall direction of effect is mixed.

Related Evidence

Other ingredients for Insomnia

Melatonin A Valerian Root A CBD A Omega-3 Fatty Acids A Tryptophan A Lavender A

Vitamin D for other conditions

Sleep Maintenance Insomnia D

Quick Verdict

Based on 56 studies (3 meta-analyses, 1 RCT) with 685,966 total participants. Results are mixed across studies.

Evidence Strength92%

High confidence

Study Breakdown

RCT (5)Meta (1)Other (50)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.