D Vitamini için Uykusuzluk

53 çalışmaya (3 meta-analyses, 1 RCT), toplam 685,942 katılımcıyla dayanmaktadır. Sonuçlar çalışmalar arasında karışıktır.

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Sonuç

The evidence on vitamin D for insomnia is mixed — low vitamin D levels are associated with poor sleep, but taking vitamin D supplements does not consistently improve insomnia symptoms.

53 studies with 685,942 participants, though mostly from observational research
Low vitamin D levels are associated with poor sleep in population studies
Supplementation results are inconsistent — not a reliable standalone sleep aid
May be most relevant for people who are vitamin D deficient

Key Study Findings

review

Vitamin D and Sleep Disorders.

Dose: None vs: Placebo Etki: None None

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None vs: Placebo Etki: None None

review

Nutritional Supplements for Healthy Aging: A Critical Analysis Review.

Dose: None vs: Placebo Etki: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Etki: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Etki: None None

systematic review and meta-analysis

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.

Dose: None vs: Placebo Etki: None None

Key Statistics

Çalışmalar

685966

Katılımcılar

↔

Mixed

Derece

Referenced Papers

Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia. Other

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Vitamin D and Sleep Disorders. Review

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Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study. Other

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Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

American journal of … 2025 6 atıf

Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other

Clinical nutrition ESPEN 2025 1 atıf

Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other

Journal of physiological … 2025 1 atıf

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review

Frontiers in neurology 2025 1 atıf

The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other

Frontiers in neurology 2025 1 atıf

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other

Research square 2025

A multimodal data-based diagnostic model for predicting vestibular migraine: a retrospective study. Other

Frontiers in neurology 2025

Risperidone-Induced Paradoxical Agitation in a Child With Lamb-Shaffer Syndrome, Autism Spectrum Disorder, and Attention Deficit Hyperactivity Disorder: A Case Report. Case Report

Cureus 2025

Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study. Other

Medicine 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review. Case Report

Frontiers in toxicology 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Corrigendum: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2025

Beyond bone health: mental and sleep health consequences of vitamin D deficiency in emerging adulthood-findings from a large-scale university study. Other

Psychology, health & … 2025

Top studies of 2024 relevant to primary care: From the PEER team. Review

Canadian family physician … 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia. Case Report

Cureus 2024 2 atıf

A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases. Review

Neuroimmunomodulation 2024 2 atıf

Clinical and genetic associations for night eating syndrome in a patient biobank. Other

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Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. Other

BMC neurology 2024 1 atıf

Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study. Other

Nature and science … 2024 1 atıf

[Advances in Mendelian randomization studies on autism spectrum disorder]. Review

Zhongguo dang dai … 2024

Commentary: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2024

Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis

Psychiatry and clinical … 2023 67 atıf

Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other

International journal of … 2023 19 atıf

Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other

The Journal of … 2023 9 atıf

Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review

Current oncology reports 2023 5 atıf

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 atıf

Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report

Frontiers in neurology 2023 3 atıf

The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other

Frontiers in nutrition 2023 3 atıf

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other

Heliyon 2023 3 atıf

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 atıf

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety. Other

Human brain mapping 2023

Digital Addiction and Sleep. Review

International journal of … 2022 107 atıf

The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review

International journal of … 2022 36 atıf

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 atıf

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 atıf

Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review. Systematic Review

Pharmacological research 2022 9 atıf

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 atıf

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 atıf

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 atıf

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 atıf

Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Other

Sleep medicine: X 2022 2 atıf

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. Other

International journal of … 2021 25 atıf

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 atıf

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 atıf

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other

Sleep medicine: X 2021 9 atıf

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other

Basic and clinical … 2021 2 atıf

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 atıf

Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other

Diabetes care 2020 110 atıf

Quality of life of patients more than 1 year after surgery for thyroid cancer. Other

Hormones (Athens, Greece) 2020 20 atıf

Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other

Food science & … 2020 17 atıf

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 atıf

Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other

Journal of the … 2019 58 atıf

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 atıf

Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other

Acta neurologica Scandinavica 2019 36 atıf

Association between Vitamin D Status and Premenstrual Symptoms. Other

Journal of the … 2019 16 atıf

Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other

PloS one 2018 69 atıf

Complement systems C4, C3 and CH50 not subject to a circadian rhythm. Other

Diagnosis (Berlin, Germany) 2018 4 atıf

Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. Other

Clinica chimica acta; … 2017 14 atıf

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … Other

Medical hypotheses 2016 105 atıf

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

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Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults. Other

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Effects of a phyto complex on well-being of climacteric women. Observational

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Viscum album (mistletoe) for pancreatic cancer, electromagnetic field therapy for osteoarthritis, homeopathy for multidrug-resistant tuberculosis, vitamin D for depression, acupuncture … Other

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Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia? Other

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Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Other

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Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

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Acta psychiatrica Scandinavica 1979 22 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 600-800 IU/day
deficiency:: 1,000-5,000 IU/day

Üst sınır: 4,000 IU/day

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

En iyi alım zamanı: Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Hypercalcemia at high doses
⚠ Nausea
⚠ Constipation
⚠ Kidney stones (rare, with excessive intake)

Bilinen Etkileşimler

● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
● Statins — vitamin D may affect statin metabolism

Tolere edilebilir üst alım: 4,000 IU/day

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does D Vitamini help with Uykusuzluk?

Based on 56 studies with 685,966 participants, there is strong evidence from multiple clinical trials that D Vitamini may support Uykusuzluk management. Our evidence grade is A (Strong Evidence).

How much D Vitamini should I take for Uykusuzluk?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of D Vitamini?

Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for D Vitamini and Uykusuzluk?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 56 peer-reviewed studies with 685,966 total participants. The overall direction of effect is mixed.

Related Evidence

Şu durum için diğer içerikler: Uykusuzluk

Melatonin A Valerian Kökü A CBD A Omega-3 Yağ Asitleri A Tryptophan A Lavanta A

D Vitamini diğer sağlık durumları için

Uyku Sürdürme Uykusuzluğu D

Hızlı Değerlendirme

53 çalışmaya (3 meta-analyses, 1 RCT), toplam 685,942 katılımcıyla dayanmaktadır. Sonuçlar çalışmalar arasında karışıktır.

Evidence Strength92%

High confidence

Çalışma Dağılımı

RCT (5)Meta (1)Other (50)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Uykusuzluk

Daha Fazla Bilgi

FDA Sorumluluk Reddi: Bu ifadeler Gıda ve İlaç Dairesi (FDA) tarafından değerlendirilmemiştir. Bu web sitesindeki ürünler ve bilgiler herhangi bir hastalığı teşhis etmek, tedavi etmek, iyileştirmek veya önlemek amacıyla tasarlanmamıştır. Sunulan kanıt dereceleri, yayımlanmış hakemli araştırmalarımızın analizine dayanmaktadır ve tıbbi tavsiye niteliği taşımamaktadır. Herhangi bir takviye rejimine başlamadan önce her zaman sağlık uzmanınıza danışın.