ビタミンD ：不眠症

合計685,942名の参加者を対象とした53件の研究（メタアナリシス3件、RCT 1件を含む）に基づく。研究間で結果にばらつきが見られる。

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結論

The evidence on vitamin D for insomnia is mixed — low vitamin D levels are associated with poor sleep, but taking vitamin D supplements does not consistently improve insomnia symptoms.

53 studies with 685,942 participants, though mostly from observational research
Low vitamin D levels are associated with poor sleep in population studies
Supplementation results are inconsistent — not a reliable standalone sleep aid
May be most relevant for people who are vitamin D deficient

Key Study Findings

review

Vitamin D and Sleep Disorders.

Dose: None vs: Placebo 効果: None None

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None vs: Placebo 効果: None None

review

Nutritional Supplements for Healthy Aging: A Critical Analysis Review.

Dose: None vs: Placebo 効果: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo 効果: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo 効果: None None

systematic review and meta-analysis

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

685966

参加者数

↔

Mixed

グレード

Referenced Papers

Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia. Other

The Journal of … 2026

Vitamin D and Sleep Disorders. Review

Advances in experimental … 2026

Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study. Other

Child psychiatry and … 2025 6 件の引用

Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

American journal of … 2025 6 件の引用

Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other

Clinical nutrition ESPEN 2025 1 件の引用

Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other

Journal of physiological … 2025 1 件の引用

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review

Frontiers in neurology 2025 1 件の引用

The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other

Frontiers in neurology 2025 1 件の引用

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other

Research square 2025

A multimodal data-based diagnostic model for predicting vestibular migraine: a retrospective study. Other

Frontiers in neurology 2025

Risperidone-Induced Paradoxical Agitation in a Child With Lamb-Shaffer Syndrome, Autism Spectrum Disorder, and Attention Deficit Hyperactivity Disorder: A Case Report. Case Report

Cureus 2025

Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study. Other

Medicine 2025

Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review. Case Report

Frontiers in toxicology 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Corrigendum: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2025

Beyond bone health: mental and sleep health consequences of vitamin D deficiency in emerging adulthood-findings from a large-scale university study. Other

Psychology, health & … 2025

Top studies of 2024 relevant to primary care: From the PEER team. Review

Canadian family physician … 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia. Case Report

Cureus 2024 2 件の引用

A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases. Review

Neuroimmunomodulation 2024 2 件の引用

Clinical and genetic associations for night eating syndrome in a patient biobank. Other

Journal of eating … 2024 1 件の引用

Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. Other

BMC neurology 2024 1 件の引用

Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study. Other

Nature and science … 2024 1 件の引用

[Advances in Mendelian randomization studies on autism spectrum disorder]. Review

Zhongguo dang dai … 2024

Commentary: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2024

Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis

Psychiatry and clinical … 2023 67 件の引用

Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other

International journal of … 2023 19 件の引用

Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other

The Journal of … 2023 9 件の引用

Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review

Current oncology reports 2023 5 件の引用

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 件の引用

Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report

Frontiers in neurology 2023 3 件の引用

The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other

Frontiers in nutrition 2023 3 件の引用

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other

Heliyon 2023 3 件の引用

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 件の引用

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety. Other

Human brain mapping 2023

Digital Addiction and Sleep. Review

International journal of … 2022 107 件の引用

The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review

International journal of … 2022 36 件の引用

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 件の引用

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 件の引用

Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review. Systematic Review

Pharmacological research 2022 9 件の引用

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 件の引用

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 件の引用

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 件の引用

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 件の引用

Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Other

Sleep medicine: X 2022 2 件の引用

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. Other

International journal of … 2021 25 件の引用

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 件の引用

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 件の引用

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other

Sleep medicine: X 2021 9 件の引用

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other

Basic and clinical … 2021 2 件の引用

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 件の引用

Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other

Diabetes care 2020 110 件の引用

Quality of life of patients more than 1 year after surgery for thyroid cancer. Other

Hormones (Athens, Greece) 2020 20 件の引用

Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other

Food science & … 2020 17 件の引用

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 件の引用

Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other

Journal of the … 2019 58 件の引用

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 件の引用

Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other

Acta neurologica Scandinavica 2019 36 件の引用

Association between Vitamin D Status and Premenstrual Symptoms. Other

Journal of the … 2019 16 件の引用

Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other

PloS one 2018 69 件の引用

Complement systems C4, C3 and CH50 not subject to a circadian rhythm. Other

Diagnosis (Berlin, Germany) 2018 4 件の引用

Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. Other

Clinica chimica acta; … 2017 14 件の引用

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … Other

Medical hypotheses 2016 105 件の引用

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 件の引用

Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults. Other

PloS one 2015 35 件の引用

Effects of a phyto complex on well-being of climacteric women. Observational

The journal of … 2015 13 件の引用

Viscum album (mistletoe) for pancreatic cancer, electromagnetic field therapy for osteoarthritis, homeopathy for multidrug-resistant tuberculosis, vitamin D for depression, acupuncture … Other

Explore (New York, … 2015 7 件の引用

Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia? Other

Breast cancer research … 2015

Sleep symptoms associated with intake of specific dietary nutrients. Other

Journal of sleep … 2014 236 件の引用

Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. Other

PloS one 2014 106 件の引用

Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial. RCT

BMJ (Clinical research … 2014 8 件の引用

[Psychotic disorder induced by Fahr's syndrome: a case report]. Case Report

L'Encephale 2014 7 件の引用

Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Other

Journal of child … 2013 18 件の引用

Occurrence of milnacipran-associated morbilliform rash and serotonin toxicity. Case Report

The Annals of … 2013

Outcomes in older versus younger patients over 96 weeks in HIV-1- infected patients treated with rilpivirine or efavirenz in ECHO … RCT

Current HIV research 2013

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 件の引用

Intensive session: New approaches to medical issues in long-term care. Review

Journal of the … 2007

Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Other

Cancer biotherapy & … 2006 29 件の引用

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Sleep behavior disorders in a large cohort of chinese (Taiwanese) patients maintained by long-term hemodialysis. Other

American journal of … 2006

[Hypoparathyroidism associated with systemic lupus erythematosus: a case]. Case Report

Annales d'endocrinologie 2006

Exercise effects on menopausal risk factors of early postmenopausal women: 3-yr Erlangen fitness osteoporosis prevention study results. Other

Medicine and science … 2005

Endometrial effects during hormone replacement therapy with a sequential oestradiol valerate/cyproterone acetate preparation. RCT

Maturitas 1993

Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. Other

Acta psychiatrica Scandinavica 1979 22 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 600-800 IU/day
deficiency:: 1,000-5,000 IU/day

上限量： 4,000 IU/day

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

報告されている副作用

⚠ Hypercalcemia at high doses
⚠ Nausea
⚠ Constipation
⚠ Kidney stones (rare, with excessive intake)

既知の相互作用

● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
● Statins — vitamin D may affect statin metabolism

耐容上限摂取量： 4,000 IU/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does ビタミンD help with 不眠症?

Based on 56 studies with 685,966 participants, there is strong evidence from multiple clinical trials that ビタミンD may support 不眠症 management. Our evidence grade is A (Strong Evidence).

How much ビタミンD should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of ビタミンD?

Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for ビタミンD and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 56 peer-reviewed studies with 685,966 total participants. The overall direction of effect is mixed.

Related Evidence

に関する他の成分：不眠症

メラトニン A バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ラベンダー A

ビタミンD 他の症状・状態について

中途覚醒型不眠症 D

総合評価

合計685,942名の参加者を対象とした53件の研究（メタアナリシス3件、RCT 1件を含む）に基づく。研究間で結果にばらつきが見られる。

Evidence Strength92%

High confidence

研究の内訳

RCT (5)Meta (1)Other (50)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

ビタミンD ： 不眠症

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： 不眠症

ビタミンD 他の症状・状態について

ビタミンD ：不眠症

に関する他の成分：不眠症