メラトニン：不眠症

Q: Does メラトニン help with 不眠症?

Based on 237 studies with 54,266 participants, there is strong evidence from multiple clinical trials that メラトニン may support 不眠症 management. Our evidence grade is A (Strong Evidence).

Q: How much メラトニン should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of メラトニン?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for メラトニン and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 237 peer-reviewed studies with 54,266 total participants. The overall direction of effect is positive.

合計44,766名の参加者を対象とした143件の研究（メタアナリシス13件、RCT 15件を含む）に基づく。143件中92件の研究で肯定的な効果が示されている。

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結論

Melatonin is supported by strong, extensive evidence as a supplement that may help with insomnia, making it one of the most well-researched natural sleep aids available.

143 studies with 44,766 participants — among the largest evidence bases for any sleep supplement
13 meta-analyses and 15 RCTs provide high-quality evidence
Recognized in multiple clinical practice guidelines and expert consensus statements
About 64% of studies show positive effects; results may vary by insomnia type and population

Key Study Findings

Other

A bedside-savior for insomnia and anxiety disorders: melatonin/buspirone hydrochloride compound oral fast-dissolving film.

Dose: melatonin + buspirone hydrochloride vs: None Outcome: product development for insomnia with anxiety 効果: None None

対象集団: patients with insomnia and anxiety disorders (formulation development)

review

Pediatric Insomnia.

Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) vs: Placebo 効果: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None

animal study

Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal …

Dose: Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified vs: Placebo 効果: None None

Observational Study n=55

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children …

Dose: None vs: None Outcome: correlation between sleep problems and morning serum melatonin … 効果: None p<0.05

対象集団: Japanese 5-year-old children (45 ASD, 10 non-ASD)

Controlled Clinical Trial n=24 2 weeks

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats.

Dose: 10 mg/kg body weight vs: Sodium arsenite group (SA, no riboceine) Outcome: Hepato-nephrotoxicity markers (ALT, AST, creatinine) 効果: None None

対象集団: Rats with sodium arsenite-induced toxicity

review

Delayed sleep-wake phase disorder.

Dose: Scheduled melatonin, scheduled sleep-wake times, bright light therapy vs: Placebo 効果: None None

Key Statistics

237

研究数

54266

参加者数

↑

Positive

グレード

Referenced Papers

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Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal apoptosis. Other

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A bedside-savior for insomnia and anxiety disorders: melatonin/buspirone hydrochloride compound oral fast-dissolving film. Other

European journal of … 2026

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder. Other

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Navigating Melatonin Safety: Fact, Fiction, and Confounders. Other

Journal of pineal … 2026

Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: Results of European neuropsychopharmacology and sleep expert's consensus … Systematic Review

Sleep medicine 2025 13 件の引用

Melatonin use in typically developing (TD) children: International Pediatric Sleep Association (IPSA) Expert Consensus Recommendations for Healthcare Providers. Other

Sleep medicine 2025 13 件の引用

Insomnia in older adults: A review of treatment options. Review

Cleveland Clinic journal … 2025 12 件の引用

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 件の引用

Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

American journal of … 2025 6 件の引用

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Review

Sleep medicine 2025 4 件の引用

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment. Review

Handbook of clinical … 2025 4 件の引用

Effect of graduated drug therapy for moderate-to-severe chronic insomnia on the severity of disease: an observational study in Germany. Observational

Journal of clinical … 2025 3 件の引用

Neurochemical Insights into the Role of Tryptophan Metabolites and Kynurenine Pathway in Insomnia and its Psychological and Neurological Comorbidities. Review

Molecular neurobiology 2025 3 件の引用

Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to … Other

Neuroscience letters 2025 3 件の引用

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 件の引用

Melatonin's paradox: From therapeutic benefits to toxicity warnings. Review

Chemico-biological interactions 2025 2 件の引用

ADHD as a circadian rhythm disorder: evidence and implications for chronotherapy. Other

Frontiers in psychiatry 2025 1 件の引用

Melatonin dose and timing: Do we have it right? Review

CNS spectrums 2025 1 件の引用

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial. RCT

PloS one 2025 1 件の引用

Circadian Rhythm Timing and Associations With Sleep Symptoms in People With Insomnia. Other

Journal of pineal … 2025 1 件の引用

Delayed sleep-wake phase disorder. Review

JAAPA : official … 2025 1 件の引用

Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications. Review

Sleep & breathing … 2025

Therapeutic Dilemma: Melatonin or not? Other

Paediatrics & child … 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Unraveling Cannabidiol's Bidirectional Regulation of Melatonin Pharmacokinetics via PEPT1/CYP1A2: Mechanistic Insights and Quantitative Projections. Other

Pharmaceuticals (Basel, Switzerland) 2025

Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin Signaling Activation. Other

Neurochemical research 2025

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats. Other

Nigerian journal of … 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Melatonin for blood pressure control in adults. Other

The Cochrane database … 2025

A prospective randomized controlled trial of antioxidants in human IVF and embryo culture media. RCT

Human reproduction (Oxford, … 2025

Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential. Review

Sleep medicine reviews 2025

[Sleep and neurodevelopment: a timely subject]. Review

Biologie aujourd'hui 2025

Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views. Review

Journal of pineal … 2024 40 件の引用

Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response … Meta-Analysis

Journal of pineal … 2024 31 件の引用

Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric … Other

Sleep medicine 2024 24 件の引用

Herbal and Natural Supplements for Improving Sleep: A Literature Review. Other

Psychiatry investigation 2024 24 件の引用

Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical … RCT

Advances in therapy 2024 24 件の引用

Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis. Meta-Analysis

JNCI cancer spectrum 2024 24 件の引用

Evaluation and management of insomnia in the clinical practice in Italy: a 2023 update from the Insomnia Expert Consensus Group. Review

Journal of neurology 2024 21 件の引用

European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children. Review

European journal of … 2024 19 件の引用

Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model. Other

Antioxidants (Basel, Switzerland) 2024 17 件の引用

Molecular strategies to enhance the keratinase gene expression and its potential implications in poultry feed industry. Other

Poultry science 2024 17 件の引用

Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice. Other

Journal of ethnopharmacology 2024 13 件の引用

The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics … Other

Journal of ethnopharmacology 2024 13 件の引用

Delayed sleep wake phase disorder in adolescents: an updated review. Review

Current opinion in … 2024 12 件の引用

Autism Spectrum Disorder and Sleep. Review

The Psychiatric clinics … 2024 11 件の引用

Inhibition of sulfur assimilation by S-benzyl-L-cysteine: Impacts on growth, photosynthesis, and leaf proteome of maize plants. Other

Plant physiology and … 2024 9 件の引用

Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. RCT

Frontiers in endocrinology 2024 9 件の引用

Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Review

Sleep medicine 2024 8 件の引用

Pharmacological and non-pharmacological management of sleep disturbances in Parkinson's disease: if when and how. Review

Expert opinion on … 2024 7 件の引用

Melatonin and melatonin receptor agonists in the treatment of nocturia: A systematic review. Systematic Review

Neurourology and urodynamics 2024 7 件の引用

Melatonin use in infants and toddlers. Other

Sleep medicine 2024 6 件の引用

Biosynthetic Pathways of Tryptophan Metabolites in Saccharomyces cerevisiae Strain: Insights and Implications. Other

International journal of … 2024 5 件の引用

Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized … RCT

Journal of palliative … 2024 5 件の引用

A scoping review of over-the-counter products for depression, anxiety and insomnia in older people. Review

BMC complementary medicine … 2024 5 件の引用

Commonly encountered symptoms and their management in patients with cirrhosis. Review

Frontiers in medicine 2024 4 件の引用

Catching ZZZs: A Summary of the Most Common Herbal Medications Taken for Insomnia. Review

American journal of … 2024 3 件の引用

The use of prolonged-release melatonin in circadian medicine: a systematic review. Systematic Review

Minerva medica 2024 3 件の引用

Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised … Other

Indian journal of … 2024 3 件の引用

Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium … RCT

Nutrients 2024 3 件の引用

Impact of N-acetyl-L-cysteine on spindle morphology and reactive oxygen species in vitrified/warmed in vitro matured bovine oocytes. Other

Reproduction in domestic … 2024 2 件の引用

[Melatonin for the regulation of sleep and other biological rhythms]. Review

Zhurnal nevrologii i … 2024

[Pharmacotherapies for insomnia]. Other

La Revue du … 2024

Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. RCT

Journal of dietary … 2024

The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. Review

Journal of sleep … 2023 505 件の引用

Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Review

Clinical interventions in … 2023 41 件の引用

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 件の引用

Melatonin as a Chronobiotic with Sleep-promoting Properties. Review

Current neuropharmacology 2023 38 件の引用

Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. Meta-Analysis

Neuropediatrics 2023 21 件の引用

Efficacy of melatonin and ramelteon for the acute and long-term management of insomnia disorder in adults: A systematic review and … Meta-Analysis

Journal of sleep … 2023 17 件の引用

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice. Other

Frontiers in pharmacology 2023 14 件の引用

Complementary and alternative treatments for insomnia disorder: a systematic umbrella review. Systematic Review

Journal of sleep … 2023 12 件の引用

Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats. Other

Journal of acupuncture … 2023 11 件の引用

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity. Other

Pharmaceutics 2023 7 件の引用

Objective Diagnosis of Circadian Rhythm Disorders. Other

Journal of clinical … 2023 6 件の引用

Updates and confounding factors in delayed sleep-wake phase disorder. Review

Sleep and biological … 2023 6 件の引用

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 件の引用

Influence of mental health medication on microbiota in the elderly population in the Valencian region. Other

Frontiers in microbiology 2023 3 件の引用

Melatonin and Aging. Review

Sub-cellular biochemistry 2023 2 件の引用

The Involvement of Melatonin and Tasimelteon against Alzheimer's Disease. Review

Current drug safety 2023 2 件の引用

Digital Addiction and Sleep. Review

International journal of … 2022 107 件の引用

Melatonin in sleep disorders. Review

Neurologia 2022 78 件の引用

Physiological and pharmacological perspectives of melatonin. Review

Archives of physiology … 2022 69 件の引用

Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses. Meta-Analysis

Sleep medicine reviews 2022 48 件の引用

Melatonin in sleep disorders. Review

Neurologia 2022 47 件の引用

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 件の引用

Melatonin use during pregnancy and lactation: A scoping review of human studies. Review

Revista brasileira de … 2022 30 件の引用

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

International journal of … 2022 25 件の引用

Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis. Meta-Analysis

CNS drugs 2022 25 件の引用

[Therapeutic approaches for sleep and rhythms disorders in children with ASD]. RCT

L'Encephale 2022 21 件の引用

Assessing the potential for drug interactions and long term safety of melatonin for the treatment of insomnia in children with … Review

Expert review of … 2022 17 件の引用

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

Metabolic syndrome and … 2022 16 件の引用

A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life … Other

International journal of … 2022 14 件の引用

Women's mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan-melatonin axis. Review

Frontiers in physiology 2022 10 件の引用

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia … Other

Frontiers in pharmacology 2022 9 件の引用

Melatonin as a complementary and prophylactic agent against COVID-19 in high-risk populations: A narrative review of recent findings from clinical … Review

Fundamental & clinical … 2022 5 件の引用

Inhibitory effects of zinc chloride (ZnCl2), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on Cd2+-induced abnormal cell … Other

The Science of … 2022 4 件の引用

Insomnia treatment: a new multitasking natural compound based on melatonin and cannabis extracts. Observational

La Clinica terapeutica 2022 4 件の引用

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 件の引用

Melatonin Prescribing in Assisted Living. Other

Journal of the … 2022 4 件の引用

Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Other

Nature communications 2022

Sleep and Diet: Mounting Evidence of a Cyclical Relationship. Other

Annual review of … 2021 149 件の引用

Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis … Meta-Analysis

Neuroscience and biobehavioral … 2021 90 件の引用

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 件の引用

Biological rhythms and chronotherapeutics in depression. Review

Progress in neuro-psychopharmacology … 2021 68 件の引用

Autism Spectrum Disorder and Sleep. Review

Child and adolescent … 2021 61 件の引用

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 件の引用

Pediatric prolonged-release melatonin for insomnia in children and adolescents with autism spectrum disorders. Other

Expert opinion on … 2021 34 件の引用

An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults … RCT

Sleep medicine 2021 32 件の引用

The effect of melatonin on sleep quality and insomnia in patients with cancer: a systematic review study. Systematic Review

Sleep medicine 2021 25 件の引用

[Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia]. RCT

Zhongguo zhen jiu … 2021 19 件の引用

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 件の引用

Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review. Review

Arquivos de neuro-psiquiatria 2021 16 件の引用

A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary … Systematic Review

The Senior care … 2021 12 件の引用

Use of Nutraceutical Ingredient Combinations in the Management of Tension-Type Headaches with or without Sleep Disorders. Review

Nutrients 2021 4 件の引用

[Nutrition impact on insomnia treatment]. Review

Nutricion hospitalaria 2021 3 件の引用

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 件の引用

Insomnia and menopause: a narrative review on mechanisms and treatments. Review

Climacteric : the … 2020 97 件の引用

Sleep Issues in Parkinson's Disease and Their Management. Review

Neurotherapeutics : the … 2020 80 件の引用

Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Meta-Analysis

Sleep medicine 2020 71 件の引用

The efficacy of melatonin and melatonin agonists in insomnia - An umbrella review. Systematic Review

Journal of psychiatric … 2020 52 件の引用

Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia: a double-blind, randomised clinical trial. RCT

Sleep medicine 2020 41 件の引用

Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review. Systematic Review

European journal of … 2020 39 件の引用

Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease. Review

Current treatment options … 2020 29 件の引用

Prescription Drugs Used in Insomnia. Review

Sleep medicine clinics 2020 27 件の引用

Dietary sources of melatonin and benefits from production of high melatonin pasteurized milk. Other

Journal of food … 2020 24 件の引用

Melatonin and melatonin agonists as treatments for benzodiazepines and hypnotics withdrawal in patients with primary insomnia. A systematic review. Systematic Review

Drug and alcohol … 2020 20 件の引用

Effect of L-cysteine, Boswellia serrata, and Whey Protein on the Antioxidant and Physicochemical Properties of Pork Patties. Other

Foods (Basel, Switzerland) 2020 15 件の引用

Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Other

Food science & … 2020 12 件の引用

Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement. Other

Journal of pharmaceutical … 2020 8 件の引用

Study on the preventive effect of ramelteon on the onset of sleep disorder after general anesthesia in patients with autism … Other

Medicine 2020 4 件の引用

Melatonin attenuates 17β-trenbolone induced insomnia-like phenotype and movement deficiency in zebrafish. Other

Chemosphere 2020 4 件の引用

Melatonin for insomnia in children. Other

The Medical letter … 2020 2 件の引用

Structural basis of ligand recognition at the human MT1 melatonin receptor. Other

Nature 2019 186 件の引用

Melatonin: Another avenue for treating osteoporosis? Review

Journal of pineal … 2019 124 件の引用

Pediatric sleep disturbances and treatment with melatonin. Review

Journal of translational … 2019 93 件の引用

Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder. RCT

Sleep medicine 2019 50 件の引用

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 件の引用

The effect of aromatherapy with lavender (Lavandula angustifolia) on serum melatonin levels. Other

Complementary therapies in … 2019 29 件の引用

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 件の引用

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 件の引用

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … Other

Laboratory animal research 2019 5 件の引用

Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Case Report

Journal of the … 2019 5 件の引用

[Melatonin and sleep disorders: Overview of literature and testing in psychiatric practice]. Review

Tijdschrift voor psychiatrie 2019 4 件の引用

Advice for travelers. Review

The Medical letter … 2019

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 件の引用

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. RCT

Journal of child … 2018 133 件の引用

Insomnia in Elderly Patients: Recommendations for Pharmacological Management. Review

Drugs & aging 2018 131 件の引用

The Relationship Between Shift Work and Men's Health. Review

Sexual medicine reviews 2018 74 件の引用

The use and misuse of exogenous melatonin in the treatment of sleep disorders. Review

Current opinion in … 2018 29 件の引用

Jetlag related sleep problems and their management: A review. Review

Travel medicine and … 2018 27 件の引用

[Melatonin: Physiological and pharmacological aspects related to sleep: The interest of a prolonged-release formulation (Circadin®) in insomnia]. Review

L'Encephale 2018 21 件の引用

Recurrent Chemical Meningitis Due to Parasellar Epidermoid Cyst. Case Report

Cureus 2018 4 件の引用

[Melatonin for children with insomnia]. Review

Ugeskrift for laeger 2018 2 件の引用

[Which alternative to benzodiazepines, Z-pills and other hypnotics for aged people ? Melatonin, valerian, or clomethiazole]. Systematic Review

Revue medicale suisse 2018 2 件の引用

The role of tryptophan metabolism in postpartum depression. Review

Metabolic brain disease 2018

[Insomnia in hospital]. Other

Nederlands tijdschrift voor … 2018

European guideline for the diagnosis and treatment of insomnia. Other

Journal of sleep … 2017 1691 件の引用

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice … Other

Journal of clinical … 2017 1097 件の引用

A review of sleep disorders and melatonin. Review

Neurological research 2017 331 件の引用

Dietary Sources and Bioactivities of Melatonin. Review

Nutrients 2017 301 件の引用

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. RCT

Journal of the … 2017 245 件の引用

Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Other

Journal of clinical … 2017 226 件の引用

Circadian Rhythm Sleep-Wake Disorders. Review

Continuum (Minneapolis, Minn.) 2017 132 件の引用

Insomnia: Pharmacologic Therapy. Review

American family physician 2017 124 件の引用

Treatment of Sleep Dysfunction in Parkinson's Disease. Review

Current treatment options … 2017 56 件の引用

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind. Review

Drugs 2017 45 件の引用

Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological … Systematic Review

Paediatric drugs 2017 26 件の引用

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 件の引用

An update of management of insomnia in patients with chronic orofacial pain. Review

Oral diseases 2017 14 件の引用

Community Pharmacists' Knowledge Regarding Donepezil Averse Effects and Self-Care Recommendations for Insomnia for Persons with AD. Other

Pharmacy (Basel, Switzerland) 2017 5 件の引用

MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Review

Annual review of … 2016 557 件の引用

Review of Safety and Efficacy of Sleep Medicines in Older Adults. Review

Clinical therapeutics 2016 328 件の引用

Pediatric Insomnia. Review

Chest 2016 109 件の引用

Melatonin has multiorgan effects. Review

European heart journal. … 2016 77 件の引用

Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression … Review

The Journal of … 2016 76 件の引用

Sleep Control, GPCRs, and Glucose Metabolism. Review

Trends in endocrinology … 2016 36 件の引用

Optimization of Corneal Epithelial Progenitor Cell Growth on Bombyx mori Silk Fibroin Membranes. Other

Stem cells international 2016 14 件の引用

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Other

Sao Paulo medical … 2015 131 件の引用

Assessment and treatment of insomnia in adult patients with alcohol use disorders. Review

Alcohol (Fayetteville, N.Y.) 2015 122 件の引用

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 件の引用

Treatment of chronic insomnia disorder in menopause: evaluation of literature. Review

Menopause (New York, … 2015 73 件の引用

Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Review

Current pharmaceutical design 2015 56 件の引用

Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. Other

The primary care … 2015 51 件の引用

Some implications of melatonin use in chronopharmacology of insomnia. Review

European journal of … 2015 38 件の引用

Irregular Sleep-Wake Rhythm Disorder. Review

Sleep medicine clinics 2015 30 件の引用

Tasimelteon for the treatment of non-24-hour sleep-wake disorder. Review

Drugs of today … 2015 15 件の引用

Is melatonin useful for jet lag? Meta-Analysis

Medwave 2015 6 件の引用

Melatonin: functions and ligands. Review

Drug discovery today 2014 191 件の引用

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Meta-Analysis

The Cochrane database … 2014 131 件の引用

Nutritional supplements for the treatment of ADHD. Review

Child and adolescent … 2014 42 件の引用

Strategies of Functional Foods Promote Sleep in Human Being. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

上限量： No established UL; 5 mg typically considered maximum

研究で検討された用量

用量	期間	効果	N
melatonin + buspirone hydrochloride	--	Neutral	--
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)	--	Positive	--
Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified	--	Positive	--
None	--	Positive	55
10 mg/kg body weight	2 weeks	Positive	24
Scheduled melatonin, scheduled sleep-wake times, bright light therapy	--	Positive	--
None	--	Mixed	--
None	--	Positive	51

推奨摂取タイミング： 30-60 minutes before bed

Safety & Side Effects

報告されている副作用

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

既知の相互作用

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

耐容上限摂取量： No established UL; 5 mg typically considered maximum

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does メラトニン help with 不眠症?

Based on 237 studies with 54,266 participants, there is strong evidence from multiple clinical trials that メラトニン may support 不眠症 management. Our evidence grade is A (Strong Evidence).

How much メラトニン should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of メラトニン?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for メラトニン and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 237 peer-reviewed studies with 54,266 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分：不眠症

バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ビタミンD A ラベンダー A

メラトニン他の症状・状態について

概日リズム障害 A 時差ぼけ A 交代勤務睡眠障害 A 入眠困難 A 加齢に伴う睡眠の変化 B

総合評価

合計44,766名の参加者を対象とした143件の研究（メタアナリシス13件、RCT 15件を含む）に基づく。143件中92件の研究で肯定的な効果が示されている。

Evidence Strength92%

High confidence

研究の内訳

RCT (25)Meta (13)Other (199)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

メラトニン ： 不眠症