Melatonin के लिए अनिद्रा

Q: Does Melatonin help with अनिद्रा?

Based on 237 studies with 54,266 participants, there is strong evidence from multiple clinical trials that Melatonin may support अनिद्रा management. Our evidence grade is A (Strong Evidence).

Q: How much Melatonin should I take for अनिद्रा?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Melatonin?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Melatonin and अनिद्रा?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 237 peer-reviewed studies with 54,266 total participants. The overall direction of effect is positive.

143 अध्ययनों (13 meta-analyses, 15 RCTs) पर आधारित, में कुल 44,766 प्रतिभागियों के साथ। 92/143 अध्ययन सकारात्मक प्रभाव दिखाते हैं।

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निष्कर्ष

Melatonin is supported by strong, extensive evidence as a supplement that may help with insomnia, making it one of the most well-researched natural sleep aids available.

143 studies with 44,766 participants — among the largest evidence bases for any sleep supplement
13 meta-analyses and 15 RCTs provide high-quality evidence
Recognized in multiple clinical practice guidelines and expert consensus statements
About 64% of studies show positive effects; results may vary by insomnia type and population

Key Study Findings

Other

A bedside-savior for insomnia and anxiety disorders: melatonin/buspirone hydrochloride compound oral fast-dissolving film.

Dose: melatonin + buspirone hydrochloride बनाम: None Outcome: product development for insomnia with anxiety प्रभाव: None None

जनसंख्या: patients with insomnia and anxiety disorders (formulation development)

review

Pediatric Insomnia.

Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) बनाम: Placebo प्रभाव: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None

animal study

Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal …

Dose: Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified बनाम: Placebo प्रभाव: None None

Observational Study n=55

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children …

Dose: None बनाम: None Outcome: correlation between sleep problems and morning serum melatonin … प्रभाव: None p<0.05

जनसंख्या: Japanese 5-year-old children (45 ASD, 10 non-ASD)

Controlled Clinical Trial n=24 2 weeks

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats.

Dose: 10 mg/kg body weight बनाम: Sodium arsenite group (SA, no riboceine) Outcome: Hepato-nephrotoxicity markers (ALT, AST, creatinine) प्रभाव: None None

जनसंख्या: Rats with sodium arsenite-induced toxicity

review

Delayed sleep-wake phase disorder.

Dose: Scheduled melatonin, scheduled sleep-wake times, bright light therapy बनाम: Placebo प्रभाव: None None

Key Statistics

237

अध्ययन

54266

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Question: Is it safe for people with cancer and other serious conditions to combine cannabidiol with melatonin when neither has … Other

Journal of clinical … None

Pediatric Insomnia. Review

Pediatrics in review 2026

Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal apoptosis. Other

Phytomedicine : international … 2026

A bedside-savior for insomnia and anxiety disorders: melatonin/buspirone hydrochloride compound oral fast-dissolving film. Other

European journal of … 2026

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder. Other

PCN reports : … 2026

Navigating Melatonin Safety: Fact, Fiction, and Confounders. Other

Journal of pineal … 2026

Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: Results of European neuropsychopharmacology and sleep expert's consensus … Systematic Review

Sleep medicine 2025 13 उद्धरण

Melatonin use in typically developing (TD) children: International Pediatric Sleep Association (IPSA) Expert Consensus Recommendations for Healthcare Providers. Other

Sleep medicine 2025 13 उद्धरण

Insomnia in older adults: A review of treatment options. Review

Cleveland Clinic journal … 2025 12 उद्धरण

Shift work sleep disorder. Review

Handbook of clinical … 2025 10 उद्धरण

Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

American journal of … 2025 6 उद्धरण

Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Review

Sleep medicine 2025 4 उद्धरण

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment. Review

Handbook of clinical … 2025 4 उद्धरण

Effect of graduated drug therapy for moderate-to-severe chronic insomnia on the severity of disease: an observational study in Germany. Observational

Journal of clinical … 2025 3 उद्धरण

Neurochemical Insights into the Role of Tryptophan Metabolites and Kynurenine Pathway in Insomnia and its Psychological and Neurological Comorbidities. Review

Molecular neurobiology 2025 3 उद्धरण

Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to … Other

Neuroscience letters 2025 3 उद्धरण

The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. Review

Molecules (Basel, Switzerland) 2025 2 उद्धरण

Melatonin's paradox: From therapeutic benefits to toxicity warnings. Review

Chemico-biological interactions 2025 2 उद्धरण

ADHD as a circadian rhythm disorder: evidence and implications for chronotherapy. Other

Frontiers in psychiatry 2025 1 उद्धरण

Melatonin dose and timing: Do we have it right? Review

CNS spectrums 2025 1 उद्धरण

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial. RCT

PloS one 2025 1 उद्धरण

Circadian Rhythm Timing and Associations With Sleep Symptoms in People With Insomnia. Other

Journal of pineal … 2025 1 उद्धरण

Delayed sleep-wake phase disorder. Review

JAAPA : official … 2025 1 उद्धरण

Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical implications. Review

Sleep & breathing … 2025

Therapeutic Dilemma: Melatonin or not? Other

Paediatrics & child … 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Unraveling Cannabidiol's Bidirectional Regulation of Melatonin Pharmacokinetics via PEPT1/CYP1A2: Mechanistic Insights and Quantitative Projections. Other

Pharmaceuticals (Basel, Switzerland) 2025

Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin Signaling Activation. Other

Neurochemical research 2025

D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats. Other

Nigerian journal of … 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Melatonin for blood pressure control in adults. Other

The Cochrane database … 2025

A prospective randomized controlled trial of antioxidants in human IVF and embryo culture media. RCT

Human reproduction (Oxford, … 2025

Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential. Review

Sleep medicine reviews 2025

[Sleep and neurodevelopment: a timely subject]. Review

Biologie aujourd'hui 2025

Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views. Review

Journal of pineal … 2024 40 उद्धरण

Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response … Meta-Analysis

Journal of pineal … 2024 31 उद्धरण

Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric … Other

Sleep medicine 2024 24 उद्धरण

Herbal and Natural Supplements for Improving Sleep: A Literature Review. Other

Psychiatry investigation 2024 24 उद्धरण

Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical … RCT

Advances in therapy 2024 24 उद्धरण

Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis. Meta-Analysis

JNCI cancer spectrum 2024 24 उद्धरण

Evaluation and management of insomnia in the clinical practice in Italy: a 2023 update from the Insomnia Expert Consensus Group. Review

Journal of neurology 2024 21 उद्धरण

European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children. Review

European journal of … 2024 19 उद्धरण

Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model. Other

Antioxidants (Basel, Switzerland) 2024 17 उद्धरण

Molecular strategies to enhance the keratinase gene expression and its potential implications in poultry feed industry. Other

Poultry science 2024 17 उद्धरण

Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice. Other

Journal of ethnopharmacology 2024 13 उद्धरण

The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics … Other

Journal of ethnopharmacology 2024 13 उद्धरण

Delayed sleep wake phase disorder in adolescents: an updated review. Review

Current opinion in … 2024 12 उद्धरण

Autism Spectrum Disorder and Sleep. Review

The Psychiatric clinics … 2024 11 उद्धरण

Inhibition of sulfur assimilation by S-benzyl-L-cysteine: Impacts on growth, photosynthesis, and leaf proteome of maize plants. Other

Plant physiology and … 2024 9 उद्धरण

Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. RCT

Frontiers in endocrinology 2024 9 उद्धरण

Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Review

Sleep medicine 2024 8 उद्धरण

Pharmacological and non-pharmacological management of sleep disturbances in Parkinson's disease: if when and how. Review

Expert opinion on … 2024 7 उद्धरण

Melatonin and melatonin receptor agonists in the treatment of nocturia: A systematic review. Systematic Review

Neurourology and urodynamics 2024 7 उद्धरण

Melatonin use in infants and toddlers. Other

Sleep medicine 2024 6 उद्धरण

Biosynthetic Pathways of Tryptophan Metabolites in Saccharomyces cerevisiae Strain: Insights and Implications. Other

International journal of … 2024 5 उद्धरण

Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized … RCT

Journal of palliative … 2024 5 उद्धरण

A scoping review of over-the-counter products for depression, anxiety and insomnia in older people. Review

BMC complementary medicine … 2024 5 उद्धरण

Commonly encountered symptoms and their management in patients with cirrhosis. Review

Frontiers in medicine 2024 4 उद्धरण

Catching ZZZs: A Summary of the Most Common Herbal Medications Taken for Insomnia. Review

American journal of … 2024 3 उद्धरण

The use of prolonged-release melatonin in circadian medicine: a systematic review. Systematic Review

Minerva medica 2024 3 उद्धरण

Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised … Other

Indian journal of … 2024 3 उद्धरण

Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium … RCT

Nutrients 2024 3 उद्धरण

Impact of N-acetyl-L-cysteine on spindle morphology and reactive oxygen species in vitrified/warmed in vitro matured bovine oocytes. Other

Reproduction in domestic … 2024 2 उद्धरण

[Melatonin for the regulation of sleep and other biological rhythms]. Review

Zhurnal nevrologii i … 2024

[Pharmacotherapies for insomnia]. Other

La Revue du … 2024

Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. RCT

Journal of dietary … 2024

The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. Review

Journal of sleep … 2023 505 उद्धरण

Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Review

Clinical interventions in … 2023 41 उद्धरण

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 उद्धरण

Melatonin as a Chronobiotic with Sleep-promoting Properties. Review

Current neuropharmacology 2023 38 उद्धरण

Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. Meta-Analysis

Neuropediatrics 2023 21 उद्धरण

Efficacy of melatonin and ramelteon for the acute and long-term management of insomnia disorder in adults: A systematic review and … Meta-Analysis

Journal of sleep … 2023 17 उद्धरण

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice. Other

Frontiers in pharmacology 2023 14 उद्धरण

Complementary and alternative treatments for insomnia disorder: a systematic umbrella review. Systematic Review

Journal of sleep … 2023 12 उद्धरण

Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats. Other

Journal of acupuncture … 2023 11 उद्धरण

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity. Other

Pharmaceutics 2023 7 उद्धरण

Objective Diagnosis of Circadian Rhythm Disorders. Other

Journal of clinical … 2023 6 उद्धरण

Updates and confounding factors in delayed sleep-wake phase disorder. Review

Sleep and biological … 2023 6 उद्धरण

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 उद्धरण

Influence of mental health medication on microbiota in the elderly population in the Valencian region. Other

Frontiers in microbiology 2023 3 उद्धरण

Melatonin and Aging. Review

Sub-cellular biochemistry 2023 2 उद्धरण

The Involvement of Melatonin and Tasimelteon against Alzheimer's Disease. Review

Current drug safety 2023 2 उद्धरण

Digital Addiction and Sleep. Review

International journal of … 2022 107 उद्धरण

Melatonin in sleep disorders. Review

Neurologia 2022 78 उद्धरण

Physiological and pharmacological perspectives of melatonin. Review

Archives of physiology … 2022 69 उद्धरण

Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses. Meta-Analysis

Sleep medicine reviews 2022 48 उद्धरण

Melatonin in sleep disorders. Review

Neurologia 2022 47 उद्धरण

Treatment of Circadian Rhythm Sleep-Wake Disorders. Review

Current neuropharmacology 2022 40 उद्धरण

Melatonin use during pregnancy and lactation: A scoping review of human studies. Review

Revista brasileira de … 2022 30 उद्धरण

The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. Systematic Review

International journal of … 2022 25 उद्धरण

Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis. Meta-Analysis

CNS drugs 2022 25 उद्धरण

[Therapeutic approaches for sleep and rhythms disorders in children with ASD]. RCT

L'Encephale 2022 21 उद्धरण

Assessing the potential for drug interactions and long term safety of melatonin for the treatment of insomnia in children with … Review

Expert review of … 2022 17 उद्धरण

Is Shift Work Sleep Disorder a Risk Factor for Metabolic Syndrome and Its Components? A Systematic Review of Cross-Sectional Studies. Systematic Review

Metabolic syndrome and … 2022 16 उद्धरण

A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life … Other

International journal of … 2022 14 उद्धरण

Women's mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan-melatonin axis. Review

Frontiers in physiology 2022 10 उद्धरण

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia … Other

Frontiers in pharmacology 2022 9 उद्धरण

Melatonin as a complementary and prophylactic agent against COVID-19 in high-risk populations: A narrative review of recent findings from clinical … Review

Fundamental & clinical … 2022 5 उद्धरण

Inhibitory effects of zinc chloride (ZnCl2), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on Cd2+-induced abnormal cell … Other

The Science of … 2022 4 उद्धरण

Insomnia treatment: a new multitasking natural compound based on melatonin and cannabis extracts. Observational

La Clinica terapeutica 2022 4 उद्धरण

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 उद्धरण

Melatonin Prescribing in Assisted Living. Other

Journal of the … 2022 4 उद्धरण

Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Other

Nature communications 2022

Sleep and Diet: Mounting Evidence of a Cyclical Relationship. Other

Annual review of … 2021 149 उद्धरण

Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis … Meta-Analysis

Neuroscience and biobehavioral … 2021 90 उद्धरण

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Review

Neurotherapeutics : the … 2021 73 उद्धरण

Biological rhythms and chronotherapeutics in depression. Review

Progress in neuro-psychopharmacology … 2021 68 उद्धरण

Autism Spectrum Disorder and Sleep. Review

Child and adolescent … 2021 61 उद्धरण

Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Systematic Review

Chronobiology international 2021 47 उद्धरण

Pediatric prolonged-release melatonin for insomnia in children and adolescents with autism spectrum disorders. Other

Expert opinion on … 2021 34 उद्धरण

An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults … RCT

Sleep medicine 2021 32 उद्धरण

The effect of melatonin on sleep quality and insomnia in patients with cancer: a systematic review study. Systematic Review

Sleep medicine 2021 25 उद्धरण

[Effect of electroacupuncture on serum melatonin and dopamine in aged insomnia]. RCT

Zhongguo zhen jiu … 2021 19 उद्धरण

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 उद्धरण

Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review. Review

Arquivos de neuro-psiquiatria 2021 16 उद्धरण

A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary … Systematic Review

The Senior care … 2021 12 उद्धरण

Use of Nutraceutical Ingredient Combinations in the Management of Tension-Type Headaches with or without Sleep Disorders. Review

Nutrients 2021 4 उद्धरण

[Nutrition impact on insomnia treatment]. Review

Nutricion hospitalaria 2021 3 उद्धरण

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 उद्धरण

Insomnia and menopause: a narrative review on mechanisms and treatments. Review

Climacteric : the … 2020 97 उद्धरण

Sleep Issues in Parkinson's Disease and Their Management. Review

Neurotherapeutics : the … 2020 80 उद्धरण

Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Meta-Analysis

Sleep medicine 2020 71 उद्धरण

The efficacy of melatonin and melatonin agonists in insomnia - An umbrella review. Systematic Review

Journal of psychiatric … 2020 52 उद्धरण

Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia: a double-blind, randomised clinical trial. RCT

Sleep medicine 2020 41 उद्धरण

Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review. Systematic Review

European journal of … 2020 39 उद्धरण

Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease. Review

Current treatment options … 2020 29 उद्धरण

Prescription Drugs Used in Insomnia. Review

Sleep medicine clinics 2020 27 उद्धरण

Dietary sources of melatonin and benefits from production of high melatonin pasteurized milk. Other

Journal of food … 2020 24 उद्धरण

Melatonin and melatonin agonists as treatments for benzodiazepines and hypnotics withdrawal in patients with primary insomnia. A systematic review. Systematic Review

Drug and alcohol … 2020 20 उद्धरण

Effect of L-cysteine, Boswellia serrata, and Whey Protein on the Antioxidant and Physicochemical Properties of Pork Patties. Other

Foods (Basel, Switzerland) 2020 15 उद्धरण

Sleep-inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals. Other

Food science & … 2020 12 उद्धरण

Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplement. Other

Journal of pharmaceutical … 2020 8 उद्धरण

Study on the preventive effect of ramelteon on the onset of sleep disorder after general anesthesia in patients with autism … Other

Medicine 2020 4 उद्धरण

Melatonin attenuates 17β-trenbolone induced insomnia-like phenotype and movement deficiency in zebrafish. Other

Chemosphere 2020 4 उद्धरण

Melatonin for insomnia in children. Other

The Medical letter … 2020 2 उद्धरण

Structural basis of ligand recognition at the human MT1 melatonin receptor. Other

Nature 2019 186 उद्धरण

Melatonin: Another avenue for treating osteoporosis? Review

Journal of pineal … 2019 124 उद्धरण

Pediatric sleep disturbances and treatment with melatonin. Review

Journal of translational … 2019 93 उद्धरण

Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder. RCT

Sleep medicine 2019 50 उद्धरण

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 उद्धरण

The effect of aromatherapy with lavender (Lavandula angustifolia) on serum melatonin levels. Other

Complementary therapies in … 2019 29 उद्धरण

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 उद्धरण

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 उद्धरण

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to … Other

Laboratory animal research 2019 5 उद्धरण

Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Case Report

Journal of the … 2019 5 उद्धरण

[Melatonin and sleep disorders: Overview of literature and testing in psychiatric practice]. Review

Tijdschrift voor psychiatrie 2019 4 उद्धरण

Advice for travelers. Review

The Medical letter … 2019

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Review

British journal of … 2018 685 उद्धरण

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. RCT

Journal of child … 2018 133 उद्धरण

Insomnia in Elderly Patients: Recommendations for Pharmacological Management. Review

Drugs & aging 2018 131 उद्धरण

The Relationship Between Shift Work and Men's Health. Review

Sexual medicine reviews 2018 74 उद्धरण

The use and misuse of exogenous melatonin in the treatment of sleep disorders. Review

Current opinion in … 2018 29 उद्धरण

Jetlag related sleep problems and their management: A review. Review

Travel medicine and … 2018 27 उद्धरण

[Melatonin: Physiological and pharmacological aspects related to sleep: The interest of a prolonged-release formulation (Circadin®) in insomnia]. Review

L'Encephale 2018 21 उद्धरण

Recurrent Chemical Meningitis Due to Parasellar Epidermoid Cyst. Case Report

Cureus 2018 4 उद्धरण

[Melatonin for children with insomnia]. Review

Ugeskrift for laeger 2018 2 उद्धरण

[Which alternative to benzodiazepines, Z-pills and other hypnotics for aged people ? Melatonin, valerian, or clomethiazole]. Systematic Review

Revue medicale suisse 2018 2 उद्धरण

The role of tryptophan metabolism in postpartum depression. Review

Metabolic brain disease 2018

[Insomnia in hospital]. Other

Nederlands tijdschrift voor … 2018

European guideline for the diagnosis and treatment of insomnia. Other

Journal of sleep … 2017 1691 उद्धरण

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice … Other

Journal of clinical … 2017 1097 उद्धरण

A review of sleep disorders and melatonin. Review

Neurological research 2017 331 उद्धरण

Dietary Sources and Bioactivities of Melatonin. Review

Nutrients 2017 301 उद्धरण

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. RCT

Journal of the … 2017 245 उद्धरण

Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Other

Journal of clinical … 2017 226 उद्धरण

Circadian Rhythm Sleep-Wake Disorders. Review

Continuum (Minneapolis, Minn.) 2017 132 उद्धरण

Insomnia: Pharmacologic Therapy. Review

American family physician 2017 124 उद्धरण

Treatment of Sleep Dysfunction in Parkinson's Disease. Review

Current treatment options … 2017 56 उद्धरण

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind. Review

Drugs 2017 45 उद्धरण

Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological … Systematic Review

Paediatric drugs 2017 26 उद्धरण

Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. Review

FP essentials 2017 15 उद्धरण

An update of management of insomnia in patients with chronic orofacial pain. Review

Oral diseases 2017 14 उद्धरण

Community Pharmacists' Knowledge Regarding Donepezil Averse Effects and Self-Care Recommendations for Insomnia for Persons with AD. Other

Pharmacy (Basel, Switzerland) 2017 5 उद्धरण

MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Review

Annual review of … 2016 557 उद्धरण

Review of Safety and Efficacy of Sleep Medicines in Older Adults. Review

Clinical therapeutics 2016 328 उद्धरण

Pediatric Insomnia. Review

Chest 2016 109 उद्धरण

Melatonin has multiorgan effects. Review

European heart journal. … 2016 77 उद्धरण

Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression … Review

The Journal of … 2016 76 उद्धरण

Sleep Control, GPCRs, and Glucose Metabolism. Review

Trends in endocrinology … 2016 36 उद्धरण

Optimization of Corneal Epithelial Progenitor Cell Growth on Bombyx mori Silk Fibroin Membranes. Other

Stem cells international 2016 14 उद्धरण

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Other

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Assessment and treatment of insomnia in adult patients with alcohol use disorders. Review

Alcohol (Fayetteville, N.Y.) 2015 122 उद्धरण

Jet Lag and Shift Work Disorder. Review

Sleep medicine clinics 2015 75 उद्धरण

Treatment of chronic insomnia disorder in menopause: evaluation of literature. Review

Menopause (New York, … 2015 73 उद्धरण

Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Review

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Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. Other

The primary care … 2015 51 उद्धरण

Some implications of melatonin use in chronopharmacology of insomnia. Review

European journal of … 2015 38 उद्धरण

Irregular Sleep-Wake Rhythm Disorder. Review

Sleep medicine clinics 2015 30 उद्धरण

Tasimelteon for the treatment of non-24-hour sleep-wake disorder. Review

Drugs of today … 2015 15 उद्धरण

Is melatonin useful for jet lag? Meta-Analysis

Medwave 2015 6 उद्धरण

Melatonin: functions and ligands. Review

Drug discovery today 2014 191 उद्धरण

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The Cochrane database … 2014 131 उद्धरण

Nutritional supplements for the treatment of ADHD. Review

Child and adolescent … 2014 42 उद्धरण

Strategies of Functional Foods Promote Sleep in Human Being. Other

Current signal transduction … 2014 41 उद्धरण

[Consensus document on the clinical use of melatonin in children and adolescents with sleep-onset insomnia]. Other

Anales de pediatria … 2014

[Insomnia, melatonin and prudence]. Other

Anales de pediatria … 2014

Meta-analysis: melatonin for the treatment of primary sleep disorders. Meta-Analysis

PloS one 2013 447 उद्धरण

Assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder. Review

Journal of the … 2013 219 उद्धरण

Circadian rhythm abnormalities. Case Report

Continuum (Minneapolis, Minn.) 2013 172 उद्धरण

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The Medical journal … 2013 59 उद्धरण

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Journal of child … 2013 56 उद्धरण

Air travel: effects of sleep deprivation and jet lag. Review

Chest 2013 53 उद्धरण

Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type. CCT

Biological psychiatry 2013 40 उद्धरण

Melatonin: comprehensive profile. Review

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Journal of pineal … 2012 322 उद्धरण

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Expert opinion on … 2012 116 उद्धरण

Melatonin in cardiovascular disease. Other

Expert opinion on … 2012 42 उद्धरण

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 उद्धरण

Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized … RCT

Journal of sleep … 2012

Shift work disorder case studies: applying management principles in clinical practice. Case Report

The Journal of … 2012

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Review

Movement disorders : … 2011 1083 उद्धरण

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled … RCT

Journal of the … 2011 138 उद्धरण

Melatonin in experimental seizures and epilepsy. Review

Pharmacological reports : … 2011 99 उद्धरण

Melatonin receptor agonists: new options for insomnia and depression treatment. Meta-Analysis

CNS neuroscience & … 2011 73 उद्धरण

Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Review

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Tasimelteon for insomnia. Review

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Perioperative melatonin use. Review

Anaesthesia and intensive … 2011 18 उद्धरण

Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD). Other

Psychopharmacology bulletin 2011 1 उद्धरण

Update on the use of melatonin in pediatrics. Review

Journal of pineal … 2011

Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. RCT

Journal of medicinal … 2010 157 उद्धरण

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Review

Advances in therapy 2010 136 उद्धरण

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Expert review of … 2010 58 उद्धरण

Keratinolytic activity of Bacillus subtilis AMR using human hair. Other

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Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag. Other

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Current treatment options … 2010

The pathophysiology of jet lag. Review

Travel medicine and … 2009 101 उद्धरण

Circadian rhythm disorders. Review

Seminars in neurology 2009 17 उद्धरण

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Der Nervenarzt 2009 6 उद्धरण

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Tidsskrift for den … 2009 6 उद्धरण

Melatonin for primary insomnia? Review

Drug and therapeutics … 2009

[Delayed sleep phase type sleep disorder and chronotherapy]. Case Report

Turk psikiyatri dergisi … 2009

Sleep timing and circadian phase in delayed sleep phase syndrome. Other

Journal of biological … 2009

Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Other

Current opinion in … 2009

Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. Other

Journal of pineal … 2009

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Review

Nature clinical practice. … 2008 139 उद्धरण

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Arzneimittel-Forschung 2008 89 उद्धरण

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Clinics in geriatric … 2008 53 उद्धरण

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Sleep medicine reviews 2008 46 उद्धरण

Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. RCT

Journal of intellectual … 2008

Complementary and alternative medicine for sleep disturbances in older adults. Review

Clinics in geriatric … 2008

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Pharmacotherapy 2007 117 उद्धरण

Insomnia associated with valerian and melatonin usage in the 2002 National Health Interview Survey. Other

Sleep 2007 58 उद्धरण

Self-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficulty. RCT

The American journal … 2007 41 उद्धरण

Circadian rhythmicity and the pharmacologic management of insomnia. Review

The American journal … 2007 3 उद्धरण

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Sleep 2007

Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. Other

The Journal of … 2007

Shift work sleep disorder: burden of illness and approaches to management. Review

Drugs 2006 110 उद्धरण

Melatonin: Nature's most versatile biological signal? Review

The FEBS journal 2006 56 उद्धरण

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Journal of psychiatric … 2006

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Seminars in neurology 2004 16 उद्धरण

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Review

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Role of melatonin in the regulation of human circadian rhythms and sleep. Review

Journal of neuroendocrinology 2003 719 उद्धरण

Melatonin in children and adolescents with insomnia: a retrospective study. Other

Clinical pediatrics 2003

Brief report: melatonin facilitates sleep in individuals with mental retardation and insomnia. RCT

Journal of autism … 2003

Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. RCT

Journal of the … 2003

Melatonin deficiencies in women. Review

Maturitas 2002 59 उद्धरण

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Primary care 2002 43 उद्धरण

Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. Review

General hospital psychiatry 2002 38 उद्धरण

[Melatonin and epilepsy]. Review

Revista de neurologia 2002 35 उद्धरण

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock. Review

Magnesium research 2002 25 उद्धरण

Melatonin in sleep disorders and jet-lag. Review

Neuro endocrinology letters 2002

Nocturnal cortisol and melatonin secretion in primary insomnia. Other

Psychiatry research 2002

Melatonin treatment for age-related insomnia. RCT

The Journal of … 2001 305 उद्धरण

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. Review

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Melatonin therapy: from benzodiazepine-dependent insomnia to authenticity and autonomy. Other

Archives of internal … 1999

[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. Other

No to hattatsu … 1999

Melatonin and jet-lag. Review

European journal of … 1999

Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Review

The Annals of … 1998 169 उद्धरण

Disorders of the sleep-wake cycle in adults. Review

Postgraduate medical journal 1998 17 उद्धरण

The physiology and pharmacology of melatonin in humans. Review

Hormone research 1998

Melatonin. Review

American family physician 1997

Melatonin and insomnia. RCT

Journal of sleep … 1996 95 उद्धरण

Nocturnal melatonin secretion and sleep after doxepin administration in chronic primary insomnia. RCT

Pharmacopsychiatry 1996

Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with … Case Report

Sleep 1993

Sulphur acquisition by Neisseria meningitidis. Other

Canadian journal of … 1984 22 उद्धरण

Carbohydrate fermentation by Clostridium difficile. Other

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Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Other

Cell 1981 747 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 0.5-3 mg, 30-60 min before bed
jetlag:: 0.5-5 mg

अधिकतम सीमा: No established UL; 5 mg typically considered maximum

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
melatonin + buspirone hydrochloride	--	Neutral	--
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)	--	Positive	--
Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified	--	Positive	--
None	--	Positive	55
10 mg/kg body weight	2 weeks	Positive	24
Scheduled melatonin, scheduled sleep-wake times, bright light therapy	--	Positive	--
None	--	Mixed	--
None	--	Positive	51

सेवन का सर्वोत्तम समय: 30-60 minutes before bed

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Daytime drowsiness
⚠ Headache
⚠ Dizziness
⚠ Nausea
⚠ Vivid dreams or nightmares

ज्ञात अंतःक्रियाएँ

● Blood thinners (warfarin) — may increase bleeding risk
● Immunosuppressants — melatonin may stimulate immune function
● Diabetes medications — may affect blood sugar levels
● Sedatives and CNS depressants — additive drowsiness

सहनीय अधिकतम सेवन: No established UL; 5 mg typically considered maximum

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Melatonin help with अनिद्रा?

Based on 237 studies with 54,266 participants, there is strong evidence from multiple clinical trials that Melatonin may support अनिद्रा management. Our evidence grade is A (Strong Evidence).

How much Melatonin should I take for अनिद्रा?

Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Melatonin?

Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Melatonin and अनिद्रा?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 237 peer-reviewed studies with 54,266 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री अनिद्रा

Valerian Root A CBD A Omega-3 Fatty Acids A Tryptophan A Vitamin D A Lavender A

Melatonin अन्य स्वास्थ्य स्थितियों के लिए

Circadian Rhythm विकार A Jet Lag A शिफ्ट वर्क नींद विकार A नींद शुरू होने में कठिनाई A उम्र से संबंधित नींद में बदलाव B

संक्षिप्त निष्कर्ष

Evidence Strength92%

High confidence

अध्ययन विश्लेषण

RCT (25)Meta (13)Other (199)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें अनिद्रा

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।