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CBD के लिए अनिद्रा

A संबंधित साक्ष्य कई बड़े नैदानिक परीक्षण लगातार महत्वपूर्ण लाभ दर्शाते हैं।

9 अध्ययनों (1 meta-analysis, 3 RCTs) पर आधारित, में कुल 1,152 प्रतिभागियों के साथ। अध्ययनों के बीच परिणाम मिश्रित हैं।

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A

निष्कर्ष

The evidence for CBD as a standalone remedy for insomnia is mixed — some studies show benefits while others do not, so more research is needed before it can be confidently recommended.

  • Results are mixed across 9 studies, even at Grade A evidence level due to study volume
  • A 2025 meta-analysis found inconsistent effects of cannabinoids on sleep quality
  • Some studies used medicinal cannabis blends rather than pure CBD, complicating comparisons
  • Individual responses to CBD for sleep may vary significantly

Key Study Findings

Randomized Controlled Trial n=20 Double-blind
Acute Effects of Oral Cannabinoids on Sleep and High-Density EEG in Insomnia: A Pilot Randomised …
Dose: 10 mg THC and 200 mg CBD बनाम: Placebo Outcome: Total sleep time and REM sleep parameters प्रभाव: -24.5 min TST; -33.9 min REM sleep p=0.05 (TST); p<0.001 (REM)

जनसंख्या: Patients with DSM-5 insomnia disorder (16F, mean age 46.1)

Review
Therapeutic Use of Cannabis and Cannabinoids: A Review.
Dose: None बनाम: None Outcome: None प्रभाव: SMD=-0.29 (nausea/vomiting); SMD=0.57 (body weight in HIV/AIDS) None

जनसंख्या: adults using cannabis or cannabinoids for medical purposes

Randomized Controlled Trial n=20 Double-blind
Effectiveness of a Cannabinoids Supplement on Sleep and Mood in Adults With Subthreshold Insomnia: A …
Dose: 3mg THC, 6mg CBN, 10mg CBD per dose बनाम: Placebo (crossover) Outcome: Sleep quality (ISI, PSQI, Bergen Insomnia Scale) प्रभाव: None p<0.05

जनसंख्या: Adults with subthreshold insomnia (mean age 47.4)

Case Reports n=1 Open-label
Green light to sleep: Does cannabis work for insomnia? A case report and brief review.
Dose: None बनाम: Prior conventional treatments (failed) Outcome: Insomnia resolution प्रभाव: None None

जनसंख्या: 37-year-old with treatment-resistant insomnia

Cohort Study n=155 52 weeks Open-label
Opioid reduction in patients with chronic non-cancer pain undergoing treatment with medicinal cannabis.
Dose: Median 15mg THC + 15mg CBD daily बनाम: Opioids only (separate cohort) Outcome: Opioid consumption reduction at 12 months प्रभाव: Median 2.7 vs 42.3 mg/day <0.05 (ITT)

जनसंख्या: Chronic non-cancer pain patients on opioids

Observational Study n=3118
Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study.
Dose: None बनाम: None Outcome: Sleep disturbance signals for ASMs in FAERS प्रभाव: 1570 insomnia reports (most frequent) None

जनसंख्या: Epilepsy patients on ASMs (FAERS Q1 2004-Q2 2025)

Key Statistics

103

अध्ययन

41554

प्रतिभागी

Mixed

A

ग्रेड

Referenced Papers

JAMA 2026 2 उद्धरण
Clinical psychology review 2025 5 उद्धरण
Journal of obstetrics … 2025 1 उद्धरण
Psychopharmacology bulletin 2025 1 उद्धरण
Clinical breast cancer 2025 1 उद्धरण
International journal of … 2024 13 उद्धरण
Cannabis and cannabinoid … 2024 10 उद्धरण
Current psychiatry reports 2024 8 उद्धरण
Cells 2024 7 उद्धरण
Clinical and translational … 2023 61 उद्धरण
Cannabis and cannabinoid … 2023 28 उद्धरण
Frontiers in pharmacology 2023 11 उद्धरण
Bioorganic chemistry 2023 5 उद्धरण
Psychiatry research 2022 43 उद्धरण
Chest 2022 41 उद्धरण
Journal of primary … 2022 28 उद्धरण
Sleep 2022 24 उद्धरण
Cannabis and cannabinoid … 2022 15 उद्धरण
Drugs in context 2022 6 उद्धरण
Journal of medical … 2021 21 उद्धरण
Current opinion in … 2021 15 उद्धरण
Advances in experimental … 2021 14 उद्धरण
Neurodegenerative disease management 2021 12 उद्धरण
Journal of cannabis … 2020 77 उद्धरण
Pharmaceuticals (Basel, Switzerland) 2020 43 उद्धरण
Multiple sclerosis journal … 2020 24 उद्धरण
Internal medicine journal 2020 18 उद्धरण
Schmerz (Berlin, Germany) 2020 8 उद्धरण
Journal of AOAC … 2019 96 उद्धरण
Current treatment options … 2019 20 उद्धरण
Medical cannabis and … 2019 14 उद्धरण
Journal of psychosocial … 2019 3 उद्धरण
The Medical letter … 2019
Current psychiatry reports 2017 394 उद्धरण
Cannabis and cannabinoid … 2016 77 उद्धरण
International journal of … 2016 16 उद्धरण
Movement disorders clinical … 2014
Journal of clinical … 2013 93 उद्धरण
British journal of … 2013 14 उद्धरण
Pharmaceuticals (Basel, Switzerland) 2012 194 उद्धरण
Occupational medicine (Oxford, … 2012 33 उद्धरण
The Urologic clinics … 2002 20 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

sleep:
25-150 mg, 1 hour before bed

अधिकतम सीमा: Not established; FDA max studied ~20 mg/kg/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक अवधि प्रभाव N
10 mg THC and 200 mg CBD -- Negative 20
None -- Mixed --
3mg THC, 6mg CBN, 10mg CBD per dose -- Positive 20
None -- Positive 1
Median 15mg THC + 15mg CBD daily 52 weeks Positive 155
None -- Mixed 3118
150 mg CBD daily 2 weeks Neutral 30
10 mg/kg/day CBD oral during pregnancy -- Negative --

सेवन का सर्वोत्तम समय: 1 hour before bed

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

  • Fatigue
  • Diarrhea
  • Changes in appetite
  • Dry mouth
  • Liver enzyme elevation at high doses

ज्ञात अंतःक्रियाएँ

  • CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
  • Blood thinners (warfarin) — CBD may increase warfarin levels
  • Clobazam — CBD significantly increases clobazam levels
  • Sedatives — additive drowsiness

सहनीय अधिकतम सेवन: Not established; FDA max studied ~20 mg/kg/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does CBD help with अनिद्रा?
Based on 103 studies with 41,554 participants, there is strong evidence from multiple clinical trials that CBD may support अनिद्रा management. Our evidence grade is A (Strong Evidence).
How much CBD should I take for अनिद्रा?
Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CBD?
Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CBD and अनिद्रा?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 103 peer-reviewed studies with 41,554 total participants. The overall direction of effect is mixed.

इसके लिए अन्य सामग्री अनिद्रा

CBD अन्य स्वास्थ्य स्थितियों के लिए

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