CBD(大麻二酚) 用于 失眠
A 证据 多项大型临床试验一致显示出显著的益处。基于9项研究(1项荟萃分析、3项RCT),共1,152名参与者。各研究结果不一。
结论
The evidence for CBD as a standalone remedy for insomnia is mixed — some studies show benefits while others do not, so more research is needed before it can be confidently recommended.
- Results are mixed across 9 studies, even at Grade A evidence level due to study volume
- A 2025 meta-analysis found inconsistent effects of cannabinoids on sleep quality
- Some studies used medicinal cannabis blends rather than pure CBD, complicating comparisons
- Individual responses to CBD for sleep may vary significantly
Key Study Findings
研究人群: Patients with DSM-5 insomnia disorder (16F, mean age 46.1)
研究人群: adults using cannabis or cannabinoids for medical purposes
研究人群: Adults with subthreshold insomnia (mean age 47.4)
研究人群: 37-year-old with treatment-resistant insomnia
研究人群: Chronic non-cancer pain patients on opioids
研究人群: Epilepsy patients on ASMs (FAERS Q1 2004-Q2 2025)
Key Statistics
103
研究数量
41554
受试者
Mixed
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 25-150 mg, 1 hour before bed
上限: Not established; FDA max studied ~20 mg/kg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 10 mg THC and 200 mg CBD | -- | Negative | 20 |
| None | -- | Mixed | -- |
| 3mg THC, 6mg CBN, 10mg CBD per dose | -- | Positive | 20 |
| None | -- | Positive | 1 |
| Median 15mg THC + 15mg CBD daily | 52 weeks | Positive | 155 |
| None | -- | Mixed | 3118 |
| 150 mg CBD daily | 2 weeks | Neutral | 30 |
| 10 mg/kg/day CBD oral during pregnancy | -- | Negative | -- |
最佳服用时间: 1 hour before bed
Safety & Side Effects
已报告的副作用
- ⚠ Fatigue
- ⚠ Diarrhea
- ⚠ Changes in appetite
- ⚠ Dry mouth
- ⚠ Liver enzyme elevation at high doses
已知相互作用
- ● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
- ● Blood thinners (warfarin) — CBD may increase warfarin levels
- ● Clobazam — CBD significantly increases clobazam levels
- ● Sedatives — additive drowsiness
可耐受最高摄入量: Not established; FDA max studied ~20 mg/kg/day
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does CBD(大麻二酚) help with 失眠?
How much CBD(大麻二酚) should I take for 失眠?
Are there side effects of CBD(大麻二酚)?
How strong is the evidence for CBD(大麻二酚) and 失眠?
Related Evidence
CBD(大麻二酚) 用于其他健康状况
References
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