缬草根 用于 失眠
A 证据 多项大型临床试验一致显示出显著的益处。基于41项研究(8项荟萃分析、2项RCT),共9,762名参与者。23/41项研究显示积极效果。
结论
Valerian root is one of the most studied herbal supplements for insomnia, and research suggests it may offer modest sleep benefits, though results are not universal.
- 41 studies with 9,762 participants — one of the most researched herbal sleep aids
- 8 meta-analyses provide substantial evidence synthesis
- About 56% of studies show positive effects — benefits may be modest
- Differences in preparations and dosing may explain why results vary across studies
Key Study Findings
研究人群: In-silico molecular docking study
研究人群: Healthy and insomnia rats
研究人群: Mouse insomnia model with network pharmacology
研究人群: Adults with occasional sleep problems
Key Statistics
105
研究数量
11983
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 300-600 mg standardized extract, 30 min before bed
上限: Not established
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 100 mg/kg VVO (high dose) | -- | Positive | -- |
| None | 3 weeks | Positive | 40 |
| None | -- | Positive | -- |
| None | -- | Positive | 51 |
最佳服用时间: 30-60 minutes before bed; may require 2-4 weeks for full effect
Safety & Side Effects
已报告的副作用
- ⚠ Headache
- ⚠ Dizziness
- ⚠ GI upset
- ⚠ Morning grogginess
- ⚠ Vivid dreams
已知相互作用
- ● Sedatives and alcohol — additive CNS depression
- ● CYP3A4-metabolized drugs — valerian may inhibit this enzyme
- ● Benzodiazepines — potential additive GABA effects
可耐受最高摄入量: Not established
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 缬草根 help with 失眠?
How much 缬草根 should I take for 失眠?
Are there side effects of 缬草根?
How strong is the evidence for 缬草根 and 失眠?
Related Evidence
缬草根 用于其他健康状况
References
- [1] Juan R Jáudenes-Marrero et al.. Foods. 2026. Metal Content in Valeriana officinalis L. Root Commercialized in a Spanish Region (Tenerife, Canary Islands). doi:10.3390/foods15050958 PubMed
- [2] Maria-Nina Căuș et al.. Pharmaceuticals (Basel). 2026. Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks. doi:10.3390/ph19030399 PubMed
- [3] Matthew W Kaufman et al.. Am J Lifestyle Med. 2025. Nutritional Supplements for Healthy Aging: A Critical Analysis Review. doi:10.1177/15598276241244725 PubMed
- [4] Yasmina M Ebrahim et al.. Naunyn Schmiedebergs Arch Pharmacol. 2025. Integrative sleep management: from molecular pathways to conventional and herbal treatments. doi:10.1007/s00210-025-04183-y PubMed
- [5] Adriana Salame et al.. Sleep Med. 2025. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. doi:10.1016/j.sleep.2025.02.027 PubMed
- [6] Kacper Żełabowski et al.. Molecules. 2025. The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs. doi:10.3390/molecules30183814 PubMed
- [7] Nathalie Schicktanz et al.. Brain Behav. 2025. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: … doi:10.1002/brb3.70600 PubMed
- [8] Halimulati Muhetaer et al.. Int J Mol Sci. 2025. Exploring the Effects and Mechanisms of Valerian Volatile Oil in Treating Insomnia Using Network Pharmacology, Molecular Docking, and Molecular Dynamics … doi:10.3390/ijms26041726 PubMed
- [9] Zhenwei Zhang et al.. Microsc Microanal. 2025. Telocytes Mediating the Effects of GABA-Herbal Medicine Composite on Insomnia. doi:10.1093/mam/ozaf113 PubMed
- [10] Aparna G Shenoy et al.. Chronobiol Int. 2025. Discovery of natural orexin 2 receptor antagonists from Valeriana species: A potential approach for insomnia treatment. doi:10.1080/07420528.2025.2529398 PubMed
- [11] Harshith Chandra Shekhar et al.. Adv Ther. 2024. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical … doi:10.1007/s12325-023-02708-6 PubMed
- [12] Ji Won Yeom et al.. Psychiatry Investig. 2024. Herbal and Natural Supplements for Improving Sleep: A Literature Review. doi:10.30773/pi.2024.0121 PubMed
- [13] Kazim Sahin et al.. Antioxidants (Basel). 2024. Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model. doi:10.3390/antiox13060657 PubMed
- [14] Mahboobeh Ghasemzadeh Rahbardar et al.. Phytother Res. 2024. Therapeutic potential of hypnotic herbal medicines: A comprehensive review. doi:10.1002/ptr.8201 PubMed
- [15] Valéria Valente et al.. Eur Neuropsychopharmacol. 2024. Does valerian work for insomnia? An umbrella review of the evidence. doi:10.1016/j.euroneuro.2024.01.008 PubMed
- [16] Hanxiao Bao et al.. J Ethnopharmacol. 2024. Safety evaluation of aqueous extract from Valeriana officinalis L. roots: Genotoxicity, acute, subchronic and teratology toxicity. doi:10.1016/j.jep.2024.118687 PubMed
- [17] Antim K Maurya et al.. Curr Top Med Chem. 2024. Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses. doi:10.2174/0115680266273617240129042653 PubMed
- [18] Anita Chabo et al.. Am J Lifestyle Med. 2024. Catching ZZZs: A Summary of the Most Common Herbal Medications Taken for Insomnia. doi:10.1177/15598276241232953 PubMed
- [19] Natalie E Pinder et al.. Behav Brain Res. 2024. Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice. doi:10.1016/j.bbr.2023.114717 PubMed
- [20] Fei-Yi Zhao et al.. Front Public Health. 2023. Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and critical assessment of comprehensive clinical … doi:10.3389/fpubh.2023.1157419 PubMed
- [21] Johanna Ell et al.. J Sleep Res. 2023. Complementary and alternative treatments for insomnia disorder: a systematic umbrella review. doi:10.1111/jsr.13979 PubMed
- [22] Kyung-Bok Lee et al.. Biomol Ther (Seoul). 2023. Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment. doi:10.4062/biomolther.2023.014 PubMed
- [23] Fanny Mulder et al.. Pharmacy (Basel). 2023. Counselling for Chronic Insomnia in Swiss Pharmacies: A Survey Study Based on Case Vignettes. doi:10.3390/pharmacy11030105 PubMed
- [24] Maša Kenda et al.. Molecules. 2022. Medicinal Plants Used for Anxiety, Depression, or Stress Treatment: An Update. doi:10.3390/molecules27186021 PubMed
- [25] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
- [26] Wenfei Wang et al.. Front Nutr. 2022. Valerian essential oil for treating insomnia via the serotonergic synapse pathway. doi:10.3389/fnut.2022.927434 PubMed
- [27] Kanika Verma et al.. Cureus. 2022. The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. doi:10.7759/cureus.28425 PubMed
- [28] Misato Ota et al.. J Ethnopharmacol. 2022. Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its … doi:10.1016/j.jep.2022.115625 PubMed
- [29] Le Huyen Tram et al.. Nat Prod Res. 2022. Secondary metabolites from Valeriana jatamansi with their anti-inflammatory activity. doi:10.1080/14786419.2021.2004600 PubMed
- [30] Oliviero Bruni et al.. Nutrients. 2021. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. doi:10.3390/nu13020530 PubMed
- [31] Silvia Borrás et al.. Planta Med. 2021. Medicinal Plants for Insomnia Related to Anxiety: An Updated Review. doi:10.1055/a-1510-9826 PubMed
- [32] Fengqin Shi et al.. Sci Rep. 2021. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. doi:10.1038/s41598-021-81620-x PubMed
- [33] Ruhi Ali et al.. Comb Chem High Throughput Screen. 2021. Nutraceuticals for Sleep Disorders. doi:10.2174/1386207324666210121111446 PubMed
- [34] Sandrah-Ann M Almond et al.. Sr Care Pharm. 2021. A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary … doi:10.4140/TCP.n.2021.83 PubMed
- [35] Diana Lelli et al.. Adv Exp Med Biol. 2021. Use of Plant-Derived Natural Products in Sleep Disturbances. doi:10.1007/978-3-030-64872-5_15 PubMed
- [36] Ashkan Soltani et al.. Sleep Sci. 2021. The effects of Valerian on sleep spindles in a model of neuropathic pain. doi:10.5935/1984-0063.20200110 PubMed
- [37] Corina Freitas et al.. Cureus. 2021. An Alternative Cause of Encephalopathy: Valerian Root Overdose. doi:10.7759/cureus.17759 PubMed
- [38] Noriko Shinjyo et al.. J Evid Based Integr Med. 2020. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. doi:10.1177/2515690X20967323 PubMed
- [39] Marta Sánchez et al.. BMC Complement Med Ther. 2020. Current uses and knowledge of medicinal plants in the Autonomous Community of Madrid (Spain): a descriptive cross-sectional study. doi:10.1186/s12906-020-03089-x PubMed
- [40] Judith Sys et al.. Eur J Clin Pharmacol. 2020. Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review. doi:10.1007/s00228-019-02812-z PubMed
- [41] Samira Ait Abdellah et al.. J Tradit Complement Med. 2020. A combination of Eschscholtzia californica Cham. and Valeriana officinalis L. extracts for adjustment insomnia: A prospective observational study. doi:10.1016/j.jtcme.2019.02.003 PubMed
- [42] Mayyada Wazaify et al.. PLoS One. 2019. Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach. doi:10.1371/journal.pone.0226076 PubMed
- [43] Vivien C Abad et al.. Drugs Aging. 2018. Insomnia in Elderly Patients: Recommendations for Pharmacological Management. doi:10.1007/s40266-018-0569-8 PubMed
- [44] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed
- [45] Jungyoon Kim et al.. J Med Food. 2018. Natural Products from Single Plants as Sleep Aids: A Systematic Review. doi:10.1089/jmf.2017.4064 PubMed
- [46] Talat Khadivzadeh et al.. J Menopausal Med. 2018. A Systematic Review and Meta-analysis on the Effect of Herbal Medicine to Manage Sleep Dysfunction in Peri- and Postmenopause. doi:10.6118/jmm.2018.24.2.92 PubMed
- [47] Jean Dumur et al.. Rev Med Suisse. 2018. [Which alternative to benzodiazepines, Z-pills and other hypnotics for aged people ? Melatonin, valerian, or clomethiazole]. PubMed
- [48] Michael J Sateia et al.. J Clin Sleep Med. 2017. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice … doi:10.5664/jcsm.6470 PubMed
- [49] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
- [50] S Eric Nybo et al.. J Biotechnol. 2017. Metabolic engineering of Escherichia coli for production of valerenadiene. doi:10.1016/j.jbiotec.2017.10.004 PubMed
- [51] Hyeon-Son Choi et al.. Biol Pharm Bull. 2017. Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster. doi:10.1248/bpb.b17-00262 PubMed
- [52] Nikola M Stojanović et al.. Saudi Pharm J. 2017. Prevalence of self-medication practice with herbal products among non-psychotic psychiatric patients from southeastern Serbia: A cross-sectional study. doi:10.1016/j.jsps.2017.02.002 PubMed
- [53] Kyungae Jo et al.. Prev Nutr Food Sci. 2017. Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus (Nelumbo nucifera) Seed and Hwang Jeong (Polygonatum sibiricum) Extracts. doi:10.3746/pnf.2017.22.4.293 PubMed
- [54] Giancarlo Palmieri et al.. Nat Sci Sleep. 2017. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical … doi:10.2147/NSS.S117770 PubMed
- [55] Marketa Marvanova et al.. Pharmacy (Basel). 2017. Community Pharmacists' Knowledge Regarding Donepezil Averse Effects and Self-Care Recommendations for Insomnia for Persons with AD. doi:10.3390/pharmacy5030042 PubMed
- [56] Jennifer L Schroeck et al.. Clin Ther. 2016. Review of Safety and Efficacy of Sleep Medicines in Older Adults. doi:10.1016/j.clinthera.2016.09.010 PubMed
- [57] Kelan Thomas et al.. Accid Anal Prev. 2016. Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. doi:10.1016/j.aap.2016.01.019 PubMed
- [58] Matthew J Leach et al.. Sleep Med Rev. 2015. Herbal medicine for insomnia: A systematic review and meta-analysis. doi:10.1016/j.smrv.2014.12.003 PubMed
- [59] Hrayr Attarian et al.. Menopause. 2015. Treatment of chronic insomnia disorder in menopause: evaluation of literature. doi:10.1097/GME.0000000000000348 PubMed
- [60] Larry Culpepper et al.. Prim Care Companion CNS Disord. 2015. Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. doi:10.4088/PCC.15r01798 PubMed
- [61] D Dalla Libera et al.. Neurol Sci. 2014. Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg. doi:10.1007/s10072-014-1756-y PubMed
- [62] Ji Hyun Baek et al.. Aust N Z J Psychiatry. 2014. Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. doi:10.1177/0004867414539198 PubMed
- [63] Jürgen Gromball et al.. Phytomedicine. 2014. Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school … doi:10.1016/j.phymed.2014.04.004 PubMed
- [64] Stephanie Maxine Ross. Holist Nurs Pract. 2014. Psychophytomedicine: an overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. doi:10.1097/HNP.0000000000000040 PubMed
- [65] Abhijit Dey et al.. Pak J Biol Sci. 2013. Phytotherapy against insomnia: extravagant claims or an alternative medicine? doi:10.3923/pjbs.2013.148.150 PubMed
- [66] Yun-Soo Yeo et al.. J Biol Chem. 2013. Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes … doi:10.1074/jbc.M112.415836 PubMed
- [67] Niteeka Maroo et al.. Indian J Pharmacol. 2013. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. doi:10.4103/0253-7613.106432 PubMed
- [68] Loreana Gallo et al.. Sci Pharm. 2012. Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization. doi:10.3797/scipharm.1206-05 PubMed
- [69] Jerome Sarris et al.. Sleep Med Rev. 2011. A systematic review of insomnia and complementary medicine. doi:10.1016/j.smrv.2010.04.001 PubMed
- [70] Simin Taavoni et al.. Menopause. 2011. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. doi:10.1097/gme.0b013e31820e9acf PubMed
- [71] Ana Nunes et al.. Acta Med Port. 2011. [Use of valerian in anxiety and sleep disorders: what is the best evidence?]. PubMed
- [72] Maria Isabel Fernández-San-Martín et al.. Sleep Med. 2010. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. doi:10.1016/j.sleep.2009.12.009 PubMed
- [73] Wilfred R Pigeon et al.. J Med Food. 2010. Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. doi:10.1089/jmf.2009.0096 PubMed
- [74] K Murphy et al.. Phytomedicine. 2010. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. doi:10.1016/j.phymed.2009.10.020 PubMed
- [75] Shanah Salter et al.. Aust Fam Physician. 2010. Treating primary insomnia - the efficacy of valerian and hops. PubMed
- [76] Gail D Anderson et al.. Phytother Res. 2010. Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women. doi:10.1002/ptr.3151 PubMed
- [77] Diana M Taibi et al.. Sleep Med. 2009. A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia. doi:10.1016/j.sleep.2008.02.001 PubMed
- [78] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
- [79] Dieter Riemann et al.. Nervenarzt. 2009. [Insomnias. II. Pharmacological and psychotherapeutic treatment options]. doi:10.1007/s00115-009-2746-9 PubMed
- [80] Jéssie Haigert Sudati et al.. Neurochem Res. 2009. In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. doi:10.1007/s11064-009-9917-8 PubMed
- [81] Syed H Tariq et al.. Clin Geriatr Med. 2008. Pharmacotherapy for insomnia. doi:10.1016/j.cger.2007.08.009 PubMed
- [82] Nalaka S Gooneratne. Clin Geriatr Med. 2008. Complementary and alternative medicine for sleep disturbances in older adults. doi:10.1016/j.cger.2007.08.002 PubMed
- [83] S Khom et al.. Neuropharmacology. 2007. Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. doi:10.1016/j.neuropharm.2007.04.018 PubMed
- [84] Diana M Taibi et al.. Sleep Med Rev. 2007. A systematic review of valerian as a sleep aid: safe but not effective. doi:10.1016/j.smrv.2007.03.002 PubMed
- [85] Anna K Morin et al.. Pharmacotherapy. 2007. Therapeutic options for sleep-maintenance and sleep-onset insomnia. doi:10.1592/phco.27.1.89 PubMed
- [86] Donald L Bliwise et al.. Sleep. 2007. Insomnia associated with valerian and melatonin usage in the 2002 National Health Interview Survey. doi:10.1093/sleep/30.7.881 PubMed
- [87] Mei Yao et al.. J Ethnopharmacol. 2007. A developmental toxicity-screening test of valerian. doi:10.1016/j.jep.2007.05.028 PubMed
- [88] Andrew D Krystal. J Clin Sleep Med. 2007. Treating the health, quality of life, and functional impairments in insomnia. PubMed
- [89] U Koetter et al.. Phytother Res. 2007. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze … doi:10.1002/ptr.2167 PubMed
- [90] Stephen Bent et al.. Am J Med. 2006. Valerian for sleep: a systematic review and meta-analysis. doi:10.1016/j.amjmed.2006.02.026 PubMed
- [91] Teruhisa Komori et al.. Chem Senses. 2006. The sleep-enhancing effect of valerian inhalation and sleep-shortening effect of lemon inhalation. doi:10.1093/chemse/bjl015 PubMed
- [92] Charles M Morin et al.. Sleep. 2005. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. doi:10.1093/sleep/28.11.1465 PubMed
- [93] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
- [94] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
- [95] Bradly P Jacobs et al.. Medicine (Baltimore). 2005. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. doi:10.1097/01.md.0000172299.72364.95 PubMed
- [96] . Prescrire Int. 2005. Management of insomnia: a place for traditional herbal remedies. PubMed
- [97] Amy Lynn Meolie et al.. J Clin Sleep Med. 2005. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. PubMed
- [98] Chun-Su Yuan et al.. Anesth Analg. 2004. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. doi:10.1213/01.ANE.0000096189.70405.A5 PubMed
- [99] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed
- [100] Bonnie J Tesch. Am J Obstet Gynecol. 2003. Herbs commonly used by women: an evidence-based review. doi:10.1067/mob.2003.402 PubMed
- [101] Susan Hadley et al.. Am Fam Physician. 2003. Valerian. PubMed
- [102] G Ziegler et al.. Eur J Med Res. 2002. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative … PubMed
- [103] Dalva R Poyares et al.. Prog Neuropsychopharmacol Biol Psychiatry. 2002. Can valerian improve the sleep of insomniacs after benzodiazepine withdrawal? doi:10.1016/s0278-5846(01)00305-0 PubMed
- [104] Bonnie J Tesch. Dis Mon. 2002. Herbs commonly used by women: an evidence-based review. PubMed
- [105] Michele M Larzelere et al.. Prim Care. 2002. Anxiety, depression, and insomnia. doi:10.1016/s0095-4543(01)00003-3 PubMed
- [106] Ka Fai Chung et al.. Gen Hosp Psychiatry. 2002. Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. doi:10.1016/s0163-8343(02)00210-4 PubMed
- [107] Ståle Pallesen et al.. Tidsskr Nor Laegeforen. 2002. [Valerian as a sleeping aid?]. PubMed
- [108] D Wheatley. Phytother Res. 2001. Kava and valerian in the treatment of stress-induced insomnia. doi:10.1002/ptr.840 PubMed
- [109] David Wheatley. Hum Psychopharmacol. 2001. Stress-induced insomnia treated with kava and valerian: singly and in combination. doi:10.1002/hup.299 PubMed
- [110] R P Brown et al.. J Psychiatr Pract. 2001. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. doi:10.1097/00131746-200103000-00002 PubMed
- [111] A D Krystal et al.. CNS Spectr. 2001. The use of valerian in neuropsychiatry. doi:10.1017/s1092852900001668 PubMed
- [112] A Balogh. Z Arztl Fortbild Qualitatssich. 2001. [Drug for the treatment of sleep disorders--review]. PubMed
- [113] A Herrera-Arellano et al.. Planta Med. 2001. Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. doi:10.1055/s-2001-18344 PubMed
- [114] C Stevinson et al.. Sleep Med. 2000. Valerian for insomnia: a systematic review of randomized clinical trials. doi:10.1016/s1389-9457(99)00015-5 PubMed
- [115] R A Dominguez et al.. Cultur Divers Ethnic Minor Psychol. 2000. Valerian as a hypnotic for Hispanic patients. doi:10.1037/1099-9809.6.1.84 PubMed
- [116] F Donath et al.. Pharmacopsychiatry. 2000. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. doi:10.1055/s-2000-7972 PubMed
- [117] T R Dockrell et al.. J Sch Nurs. 2000. An overview of herbal medications with implications for the school nurse. doi:10.1177/105984050001600308 PubMed
- [118] T B Klepser et al.. Am J Health Syst Pharm. 1999. Unsafe and potentially safe herbal therapies. doi:10.1093/ajhp/56.2.125 PubMed
- [119] A Fugh-Berman et al.. Psychosom Med. 1999. Dietary supplements and natural products as psychotherapeutic agents. doi:10.1097/00006842-199909000-00012 PubMed
- [120] E Ernst. Drugs Aging. 1999. Herbal medications for common ailments in the elderly. doi:10.2165/00002512-199915060-00002 PubMed
- [121] C K Kirkwood. J Am Pharm Assoc (Wash). 1999. Management of insomnia. doi:10.1016/s1086-5802(15)30354-5 PubMed
- [122] J Wagner et al.. Ann Pharmacother. 1998. Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. doi:10.1345/aph.17111 PubMed
- [123] W Müller-Limmroth et al.. Med Klin. 1977. [Experimental studies of the effects of Seda-Kneipp on the sleep of sleep disturbed subjects; implications for the treatment of different … PubMed
FDA 免责声明: 这些声明未经美国食品药品监督管理局(FDA)评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析,不构成医疗建议。在开始任何补充剂方案之前,请务必咨询您的医疗保健提供者。