CBD（大麻二酚） 用于 焦虑相关性睡眠问题
A 证据 多项大型临床试验一致显示出显著的益处。基于35项研究（5项荟萃分析、11项RCT），共17,358名参与者。19/35项研究显示积极效果。
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'sleepcited.com';
const params = 'ingredient\u003Dcbd\u0026condition\u003Danxiety\u002Drelated\u002Dsleep';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
结论
CBD may support better sleep in people whose rest is disrupted by anxiety, though results are mixed and the best dose and formulation are still being studied.
- 35 studies with 17,358 participants — the largest evidence base among anxiety-sleep supplements
- Roughly 54% of studies show positive effects, with others showing mixed results
- May work through 5-HT1A serotonin receptors to reduce anxiety and promote sleep
- Dosing varies widely across studies (25 mg to 300+ mg), making direct comparisons difficult
Key Study Findings
Other
Development of a novel Δ9-THC-specific color test reagent.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Lab study: novel THC-specific color test reagent
Observational Study
Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …
Dose: None
vs: None
Outcome: DALYs and mortality rates of congenital birth defects
效果: DALYs decreased 59.77%, deaths decreased 63.81%
None
研究人群: G20 countries population, 1990-2021
Other
Policy reform and the international future of Moroccan Cannabis production.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Observational Study
n=126
The use of complementary and alternative medicine among cancer patients in Hawaii.
Dose: None
vs: None
Outcome: CAM therapy use patterns among cancer patients
效果: 57.1% used at least one CAM therapy
None
研究人群: Cancer patients in Hawaii
Systematic Review
The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Healthy adults
Other
5 weeks
Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis …
Dose: 200 mg
vs: None
Outcome: Colitis severity
效果: None
None
研究人群: Mouse model
Key Statistics
35
研究数量
1794
受试者
↔
Mixed
A
等级
Referenced Papers
BMC pregnancy and …
2025
6 次引用
Forensic toxicology
2025
1 次引用
The International journal …
2025
1 次引用
BMC complementary medicine …
2025
Medical cannabis and …
2024
26 次引用
Molecular nutrition & …
2024
15 次引用
Neurochemical research
2024
14 次引用
Cannabis and cannabinoid …
2024
10 次引用
A systematic review and meta-analysis of functional vitamin B12 status among adult vegans.
Meta-Analysis
Nutrition bulletin
2024
9 次引用
International journal of …
2024
7 次引用
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.
Systematic Review
Nutrients
2024
5 次引用
The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review.
Systematic Review
Nutrients
2024
4 次引用
Pharmaceutics
2024
4 次引用
Journal of sleep …
2023
40 次引用
Mechanisms of ageing …
2023
8 次引用
A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients.
Systematic Review
Nutrition and cancer
2023
5 次引用
Food & nutrition …
2023
5 次引用
Journal of personalized …
2023
3 次引用
American family physician
2023
The Journal of …
2022
35 次引用
Proceedings. IEEE International …
2021
29 次引用
Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey.
Other
International journal of …
2021
14 次引用
Veterinary medicine (Auckland, …
2020
45 次引用
Cureus
2020
23 次引用
Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies.
Case Report
Brain sciences
2020
12 次引用
Public health nutrition
2018
35 次引用
Nutricion hospitalaria
2015
161 次引用
Current osteoporosis reports
2013
43 次引用
Adolescent medicine: state …
2013
3 次引用
Ontario health technology …
2013
Systematic review: Progression of beryllium sensitization to chronic beryllium disease.
Systematic Review
Occupational medicine (Oxford, …
2012
33 次引用
Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Systematic Review
Archives of internal …
2007
222 次引用
A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances.
Systematic Review
Prehospital emergency care
2002
33 次引用
The Urologic clinics …
2002
20 次引用
European journal of …
1989
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 25-150 mg, 1 hour before bed
上限： Not established; FDA max studied ~20 mg/kg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | 126 |
| None | -- | Positive | -- |
| 200 mg | 5 weeks | Positive | -- |
| cannabidiol (CBD) at various doses administered to mice | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： 1 hour before bed
Safety & Side Effects
已报告的副作用
- ⚠ Fatigue
- ⚠ Diarrhea
- ⚠ Changes in appetite
- ⚠ Dry mouth
- ⚠ Liver enzyme elevation at high doses
已知相互作用
- ● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
- ● Blood thinners (warfarin) — CBD may increase warfarin levels
- ● Clobazam — CBD significantly increases clobazam levels
- ● Sedatives — additive drowsiness
可耐受最高摄入量： Not established; FDA max studied ~20 mg/kg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does CBD（大麻二酚） help with 焦虑相关性睡眠问题?
Based on 35 studies with 1,794 participants, there is strong evidence from multiple clinical trials that CBD（大麻二酚） may support 焦虑相关性睡眠问题 management. Our evidence grade is A (Strong Evidence).
How much CBD（大麻二酚） should I take for 焦虑相关性睡眠问题?
Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of CBD（大麻二酚）?
Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for CBD（大麻二酚） and 焦虑相关性睡眠问题?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 35 peer-reviewed studies with 1,794 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 焦虑相关性睡眠问题
CBD（大麻二酚） 用于其他健康状况
References
- [1] Xiangwen Li et al.. BMC Pregnancy Childbirth. 2025. Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. doi:10.1186/s12884-025-07617-w PubMed
- [2] Kenji Tsujikawa et al.. Forensic Toxicol. 2025. Development of a novel Δ9-THC-specific color test reagent. doi:10.1007/s11419-025-00727-2 PubMed
- [3] Pierre-Arnaud Chouvy. Int J Drug Policy. 2025. Policy reform and the international future of Moroccan Cannabis production. doi:10.1016/j.drugpo.2025.104841 PubMed
- [4] April Hamachi et al.. BMC Complement Med Ther. 2025. The use of complementary and alternative medicine among cancer patients in Hawaii. doi:10.1186/s12906-025-04912-z PubMed
- [5] Qingchen Zhang et al.. Med Cannabis Cannabinoids. 2024. Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects. doi:10.1159/000535726 PubMed
- [6] Qi Sun et al.. Mol Nutr Food Res. 2024. Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. doi:10.1002/mnfr.202300446 PubMed
- [7] Yu-Meng Liu et al.. Neurochem Res. 2024. Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor. doi:10.1007/s11064-024-04102-2 PubMed
- [8] Mengxue He et al.. Cannabis Cannabinoid Res. 2024. Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. doi:10.1089/can.2022.0331 PubMed
- [9] Ali Niklewicz et al.. Nutr Bull. 2024. A systematic review and meta-analysis of functional vitamin B12 status among adult vegans. doi:10.1111/nbu.12712 PubMed
- [10] Dominika Szkopek et al.. Int J Mol Sci. 2024. Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions. doi:10.3390/ijms252111398 PubMed
- [11] Pedro González-Parejo et al.. Nutrients. 2024. Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. doi:10.3390/nu16142315 PubMed
- [12] Eduard Bezuglov et al.. Nutrients. 2024. The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review. doi:10.3390/nu16172840 PubMed
- [13] Shelby Coates et al.. Pharmaceutics. 2024. Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. doi:10.3390/pharmaceutics16121599 PubMed
- [14] Karin Ried et al.. J Sleep Res. 2023. Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. doi:10.1111/jsr.13793 PubMed
- [15] Kedar N Prasad. Mech Ageing Dev. 2023. A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer's … doi:10.1016/j.mad.2022.111757 PubMed
- [16] L Heilfort et al.. Nutr Cancer. 2023. A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients. doi:10.1080/01635581.2022.2098348 PubMed
- [17] Anne-Lise Bjørke-Monsen et al.. Food Nutr Res. 2023. Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. doi:10.29219/fnr.v67.10259 PubMed
- [18] Aixing Pan et al.. J Pers Med. 2023. Apical Vertebras Distribution Modifier for Coronal Balance Classification in Adult Idiopathic Scoliosis. doi:10.3390/jpm13060897 PubMed
- [19] Roland Grad et al.. Am Fam Physician. 2023. Top 20 Research Studies of 2022 for Primary Care Physicians. PubMed
- [20] Amer Haffar et al.. J Arthroplasty. 2022. Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. doi:10.1016/j.arth.2022.03.081 PubMed
- [21] Mohammad Soleymanpour et al.. Proceedings (IEEE Int Conf Bioinformatics Biomed). 2021. Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. doi:10.1109/bibm52615.2021.9669404 PubMed
- [22] Francis Lovecchio et al.. Int J Spine Surg. 2021. Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey. doi:10.14444/8087 PubMed
- [23] Joseph J Wakshlag et al.. Vet Med (Auckl). 2020. Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements. doi:10.2147/VMRR.S248712 PubMed
- [24] Jessica Bass et al.. Cureus. 2020. A Case of Toxicity from Cannabidiol Gummy Ingestion. doi:10.7759/cureus.7688 PubMed
- [25] Dominique Endres et al.. Brain Sci. 2020. Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. doi:10.3390/brainsci10060399 PubMed
- [26] Justine A Kavle et al.. Public Health Nutr. 2018. Community-based distribution of iron-folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications. doi:10.1017/S1368980017002828 PubMed
- [27] Gabriela Gutiérrez-Salmeán et al.. Nutr Hosp. 2015. NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA). doi:10.3305/nh.2015.32.1.9001 PubMed
- [28] Karin M A Swart et al.. Curr Osteoporos Rep. 2013. Vitamin B12, folic acid, and bone. doi:10.1007/s11914-013-0155-2 PubMed
- [29] Jenna X Cheng et al.. Adolesc Med State Art Rev. 2013. Considering biomedical/CAM treatments. PubMed
- [30] Health Quality Ontario. Ont Health Technol Assess Ser. 2013. Vitamin B12 and cognitive function: an evidence-based analysis. PubMed
- [31] A Seidler et al.. Occup Med (Lond). 2012. Systematic review: Progression of beryllium sensitization to chronic beryllium disease. doi:10.1093/occmed/kqs069 PubMed
- [32] Ethan M Balk et al.. Arch Intern Med. 2007. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. doi:10.1001/archinte.167.1.21 PubMed
- [33] Sue Wilson et al.. Prehosp Emerg Care. 2002. A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. doi:10.1080/10903120290938760 PubMed
- [34] Ashish M Kamat et al.. Urol Clin North Am. 2002. Chemoprevention of bladder cancer. doi:10.1016/s0094-0143(02)00022-8 PubMed
- [35] D A Bender. Eur J Clin Nutr. 1989. Vitamin B6 requirements and recommendations. PubMed
FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。