CBD untuk Masalah Tidur Terkait Kecemasan

Berdasarkan 35 studi (5 meta-analyses, 11 RCTs) dengan 17,358 peserta secara total. 19/35 studi menunjukkan efek positif.

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Kesimpulan

CBD may support better sleep in people whose rest is disrupted by anxiety, though results are mixed and the best dose and formulation are still being studied.

35 studies with 17,358 participants — the largest evidence base among anxiety-sleep supplements
Roughly 54% of studies show positive effects, with others showing mixed results
May work through 5-HT1A serotonin receptors to reduce anxiety and promote sleep
Dosing varies widely across studies (25 mg to 300+ mg), making direct comparisons difficult

Key Study Findings

Other

Development of a novel Δ9-THC-specific color test reagent.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Lab study: novel THC-specific color test reagent

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects Efek: DALYs decreased 59.77%, deaths decreased 63.81% None

Populasi: G20 countries population, 1990-2021

Other

Policy reform and the international future of Moroccan Cannabis production.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Observational Study n=126

The use of complementary and alternative medicine among cancer patients in Hawaii.

Dose: None vs: None Outcome: CAM therapy use patterns among cancer patients Efek: 57.1% used at least one CAM therapy None

Populasi: Cancer patients in Hawaii

Systematic Review

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: …

Dose: None vs: None Outcome: None Efek: None None

Populasi: Healthy adults

Other 5 weeks

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis …

Dose: 200 mg vs: None Outcome: Colitis severity Efek: None None

Populasi: Mouse model

Key Statistics

Studi

1794

Peserta

↔

Mixed

Peringkat

Referenced Papers

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 sitasi

Development of a novel Δ9-THC-specific color test reagent. Other

Forensic toxicology 2025 1 sitasi

Policy reform and the international future of Moroccan Cannabis production. Other

The International journal … 2025 1 sitasi

The use of complementary and alternative medicine among cancer patients in Hawaii. Other

BMC complementary medicine … 2025

Pharmacokinetic Variability of Oral Cannabidiol and Its Major Metabolites after Short-Term High-Dose Exposure in Healthy Subjects. Other

Medical cannabis and … 2024 26 sitasi

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 sitasi

Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor. Other

Neurochemical research 2024 14 sitasi

Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Other

Cannabis and cannabinoid … 2024 10 sitasi

A systematic review and meta-analysis of functional vitamin B12 status among adult vegans. Meta-Analysis

Nutrition bulletin 2024 9 sitasi

Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions. Other

International journal of … 2024 7 sitasi

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 sitasi

The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review. Systematic Review

Nutrients 2024 4 sitasi

Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Other

Pharmaceutics 2024 4 sitasi

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study. RCT

Journal of sleep … 2023 40 sitasi

A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer's … Other

Mechanisms of ageing … 2023 8 sitasi

A Systematic Review of the Benefit of B-Vitamins as a Complementary Treatment in Cancer Patients. Systematic Review

Nutrition and cancer 2023 5 sitasi

Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. Review

Food & nutrition … 2023 5 sitasi

Apical Vertebras Distribution Modifier for Coronal Balance Classification in Adult Idiopathic Scoliosis. Other

Journal of personalized … 2023 3 sitasi

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. RCT

The Journal of … 2022 35 sitasi

Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. Other

Proceedings. IEEE International … 2021 29 sitasi

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey. Other

International journal of … 2021 14 sitasi

Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements. Other

Veterinary medicine (Auckland, … 2020 45 sitasi

A Case of Toxicity from Cannabidiol Gummy Ingestion. Case Report

Cureus 2020 23 sitasi

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 sitasi

Community-based distribution of iron-folic acid supplementation in low- and middle-income countries: a review of evidence and programme implications. Review

Public health nutrition 2018 35 sitasi

NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA). Review

Nutricion hospitalaria 2015 161 sitasi

Vitamin B12, folic acid, and bone. Review

Current osteoporosis reports 2013 43 sitasi

Considering biomedical/CAM treatments. Review

Adolescent medicine: state … 2013 3 sitasi

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Systematic review: Progression of beryllium sensitization to chronic beryllium disease. Systematic Review

Occupational medicine (Oxford, … 2012 33 sitasi

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 sitasi

A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. Systematic Review

Prehospital emergency care 2002 33 sitasi

Chemoprevention of bladder cancer. Review

The Urologic clinics … 2002 20 sitasi

Vitamin B6 requirements and recommendations. Review

European journal of … 1989

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

sleep:: 25-150 mg, 1 hour before bed

Batas atas: Not established; FDA max studied ~20 mg/kg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	126
None	--	Positive	--
200 mg	5 weeks	Positive	--
cannabidiol (CBD) at various doses administered to mice	--	Positive	--
None	--	Positive	--

Waktu terbaik diminum: 1 hour before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Fatigue
⚠ Diarrhea
⚠ Changes in appetite
⚠ Dry mouth
⚠ Liver enzyme elevation at high doses

Interaksi yang Diketahui

● CYP3A4/CYP2C19 substrates — CBD inhibits these liver enzymes
● Blood thinners (warfarin) — CBD may increase warfarin levels
● Clobazam — CBD significantly increases clobazam levels
● Sedatives — additive drowsiness

Asupan atas yang dapat ditoleransi: Not established; FDA max studied ~20 mg/kg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does CBD help with Masalah Tidur Terkait Kecemasan?

Based on 35 studies with 1,794 participants, there is strong evidence from multiple clinical trials that CBD may support Masalah Tidur Terkait Kecemasan management. Our evidence grade is A (Strong Evidence).

How much CBD should I take for Masalah Tidur Terkait Kecemasan?

Studies have used various dosages. A commonly studied range is 25-150 mg, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of CBD?

Reported side effects may include Fatigue, Diarrhea, Changes in appetite, Dry mouth. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for CBD and Masalah Tidur Terkait Kecemasan?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 35 peer-reviewed studies with 1,794 total participants. The overall direction of effect is mixed.

Related Evidence

Bahan lain untuk Masalah Tidur Terkait Kecemasan

Kava A Lavender A Passionflower A Akar Valerian B Kemangi Suci B GABA B

CBD untuk kondisi lain

Insomnia A

Kesimpulan Singkat

Berdasarkan 35 studi (5 meta-analyses, 11 RCTs) dengan 17,358 peserta secara total. 19/35 studi menunjukkan efek positif.

Evidence Strength92%

High confidence

Rincian Studi

RCT (2)Meta (1)Other (32)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Masalah Tidur Terkait Kecemasan

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.