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Melatonin für Insomnie

A Evidenz Mehrere große klinische Studien zeigen übereinstimmend signifikante Vorteile.

Basierend auf 143 Studien (13 meta-analyses, 15 RCTs) mit 44,766 Teilnehmern insgesamt. 92/143 Studien zeigen positive Effekte.

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A

Fazit

Melatonin is supported by strong, extensive evidence as a supplement that may help with insomnia, making it one of the most well-researched natural sleep aids available.

  • 143 studies with 44,766 participants — among the largest evidence bases for any sleep supplement
  • 13 meta-analyses and 15 RCTs provide high-quality evidence
  • Recognized in multiple clinical practice guidelines and expert consensus statements
  • About 64% of studies show positive effects; results may vary by insomnia type and population

Key Study Findings

Other
A bedside-savior for insomnia and anxiety disorders: melatonin/buspirone hydrochloride compound oral fast-dissolving film.
Dose: melatonin + buspirone hydrochloride vs.: None Outcome: product development for insomnia with anxiety Wirkung: None None

Population: patients with insomnia and anxiety disorders (formulation development)

review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) vs.: Placebo Wirkung: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None
animal study
Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal …
Dose: Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified vs.: Placebo Wirkung: None None
Observational Study n=55
Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children …
Dose: None vs.: None Outcome: correlation between sleep problems and morning serum melatonin … Wirkung: None p<0.05

Population: Japanese 5-year-old children (45 ASD, 10 non-ASD)

Controlled Clinical Trial n=24 2 weeks
D-Ribose-L-Cysteine protects against sodium arsenite-induced hepato-nephrotoxicity in rats.
Dose: 10 mg/kg body weight vs.: Sodium arsenite group (SA, no riboceine) Outcome: Hepato-nephrotoxicity markers (ALT, AST, creatinine) Wirkung: None None

Population: Rats with sodium arsenite-induced toxicity

review
Delayed sleep-wake phase disorder.
Dose: Scheduled melatonin, scheduled sleep-wake times, bright light therapy vs.: Placebo Wirkung: None None

Key Statistics

237

Studien

54266

Teilnehmer

Positive

A

Bewertung

Referenced Papers

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Handbook of clinical … 2025 10 Zitierungen
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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
0.5-3 mg, 30-60 min before bed
jetlag:
0.5-5 mg

Obergrenze: No established UL; 5 mg typically considered maximum

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
melatonin + buspirone hydrochloride -- Neutral --
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) -- Positive --
Compound Chaijin Jieyu Fang (CCJF) traditional Chinese medicine formula; dose not specified -- Positive --
None -- Positive 55
10 mg/kg body weight 2 weeks Positive 24
Scheduled melatonin, scheduled sleep-wake times, bright light therapy -- Positive --
None -- Mixed --
None -- Positive 51

Beste Einnahmezeit: 30-60 minutes before bed

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams or nightmares

Bekannte Wechselwirkungen

  • Blood thinners (warfarin) — may increase bleeding risk
  • Immunosuppressants — melatonin may stimulate immune function
  • Diabetes medications — may affect blood sugar levels
  • Sedatives and CNS depressants — additive drowsiness

Tolerierbare Höchstaufnahmemenge: No established UL; 5 mg typically considered maximum

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Melatonin help with Insomnie?
Based on 237 studies with 54,266 participants, there is strong evidence from multiple clinical trials that Melatonin may support Insomnie management. Our evidence grade is A (Strong Evidence).
How much Melatonin should I take for Insomnie?
Studies have used various dosages. A commonly studied range is 0.5-3 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Insomnie?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 237 peer-reviewed studies with 54,266 total participants. The overall direction of effect is positive.

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