Reishi-Pilz für Insomnie
C Evidenz Begrenzte Evidenz aus kleinen Studien, aber es gibt einige positive Signale.Basierend auf 8 Studien (3 meta-analyses) mit 1,374 Teilnehmern insgesamt. 8/8 Studien zeigen positive Effekte.
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C
Fazit
Reishi mushroom shows promising and consistent evidence suggesting it may help support better sleep for people with insomnia.
- All 8 studies (including 3 meta-analyses) report positive effects — unusually consistent
- 1,374 total participants across available research
- Contains compounds identified as having sedative-hypnotic properties
- Evidence base is smaller but growing — more large-scale trials would be valuable
Key Study Findings
In Vitro
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in …
Dose: None
vs.: MIN6 cells without NAC
Outcome: Beta cell insulin secretion and signaling
Wirkung: None
p<0.05
Population: MIN6 beta cell line
Other
Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular …
Dose: None
vs.: None
Outcome: Muscle healthspan and calcium regulation
Wirkung: None
None
Population: C. elegans DMD model
Other
The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris.
Dose: None
vs.: None
Outcome: the production of HSA-pFSHβ
Wirkung: or 1
None
Population: None
Other
Involvement of L-Cysteine Desulfhydrase and Hydrogen Sulfide in Glutathione-Induced Tolerance to Salinity by Accelerating Ascorbate-Glutathione …
Dose: None
vs.: None
Outcome: role of L-cysteine desulfhydrase (L-DES) and endogenous hydrogen …
Wirkung: None
None
Population: None
Other
Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a …
Dose: None
vs.: None
Outcome: electrochemical detection of selenomethionine
Wirkung: None
None
Population: Analytical chemistry (selenium supplement analysis)
Controlled Clinical Trial
n=79
Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels …
Dose: None
vs.: healthy controls
Outcome: None
Wirkung: None
P=0.05
Population: type 2 diabetes patients
Key Statistics
9
Studien
79
Teilnehmer
↑
Positive
C
Bewertung
Referenced Papers
Phytomedicine : international …
2025
1 Zitierungen
Cell and tissue …
2025
Archives of medical …
2025
Phytomedicine : international …
2024
9 Zitierungen
Frontiers in pharmacology
2024
4 Zitierungen
Integrative medicine research
2024
2 Zitierungen
Cureus
2023
16 Zitierungen
Communications biology
2022
14 Zitierungen
Yeast (Chichester, England)
2021
6 Zitierungen
Antioxidants (Basel, Switzerland)
2020
30 Zitierungen
Nutrients
2019
43 Zitierungen
Cellular and molecular …
2019
12 Zitierungen
Sensors (Basel, Switzerland)
2017
5 Zitierungen
The Cochrane database …
2016
10 Zitierungen
European journal of …
2014
77 Zitierungen
Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine.
Review
Journal of immunological …
2014
13 Zitierungen
International journal of …
2013
104 Zitierungen
The Cochrane database …
2012
Journal of ethnopharmacology
2012
International journal of …
2007
56 Zitierungen
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- sleep:
- 1,000-3,000 mg extract, before bed
Obergrenze: Not established
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 79 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Beste Einnahmezeit: 1-2 hours before bed
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ GI upset
- ⚠ Dizziness
- ⚠ Dry mouth
- ⚠ Nosebleeds (rare)
Bekannte Wechselwirkungen
- ● Blood thinners — reishi may increase bleeding risk
- ● Immunosuppressants — reishi may stimulate immune function
- ● Antihypertensives — may lower blood pressure further
Tolerierbare Höchstaufnahmemenge: Not established
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Reishi-Pilz help with Insomnie?
Based on 9 studies with 79 participants, there is limited but promising evidence that Reishi-Pilz may support Insomnie management. Our evidence grade is C (Some Evidence).
How much Reishi-Pilz should I take for Insomnie?
Studies have used various dosages. A commonly studied range is 1,000-3,000 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Reishi-Pilz?
Reported side effects may include GI upset, Dizziness, Dry mouth, Nosebleeds (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Reishi-Pilz and Insomnie?
We rate the evidence as Grade C (Some Evidence). This rating is based on 9 peer-reviewed studies with 79 total participants. The overall direction of effect is positive.
Related Evidence
Andere Inhaltsstoffe für Insomnie
References
- [1] Wei Chen et al.. Phytomedicine. 2025. Sedative-hypnotic effects of an herbal formulation comprising Ganoderma, Gastrodiae Rhizoma, and Chrysanthemi Flos in mice. doi:10.1016/j.phymed.2025.157374 PubMed
- [2] Meg Schuurman et al.. Cell Tissue Res. 2025. The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells. doi:10.1007/s00441-025-04020-x PubMed
- [3] Xu Wang et al.. Arch Med Sci. 2025. Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine. doi:10.5114/aoms/207509 PubMed
- [4] Wei Chen et al.. Phytomedicine. 2024. Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. doi:10.1016/j.phymed.2024.155355 PubMed
- [5] Yu Qin et al.. Front Pharmacol. 2024. Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease. doi:10.3389/fphar.2024.1390294 PubMed
- [6] Xiaotong Li et al.. Integr Med Res. 2024. Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients. doi:10.1016/j.imr.2024.101089 PubMed
- [7] Nguyen Huu Lac Thuy et al.. Cureus. 2023. Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review. doi:10.7759/cureus.44574 PubMed
- [8] Rebecca A Ellwood et al.. Commun Biol. 2022. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. doi:10.1038/s42003-022-04212-z PubMed
- [9] Gang Luo et al.. Yeast. 2021. The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris. doi:10.1002/yea.3668 PubMed
- [10] Cengiz Kaya et al.. Antioxidants (Basel). 2020. Involvement of L-Cysteine Desulfhydrase and Hydrogen Sulfide in Glutathione-Induced Tolerance to Salinity by Accelerating Ascorbate-Glutathione Cycle and Glyoxalase System in … doi:10.3390/antiox9070603 PubMed
- [11] Feiya Sheng et al.. Nutrients. 2019. Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo. doi:10.3390/nu12010085 PubMed
- [12] Xia Feng et al.. Cell Mol Biol (Noisy-le-grand). 2019. Anti-inflammatory, anti-nociceptive and sedative-hypnotic activities of lucidone D extracted from Ganoderma lucidum. PubMed
- [13] Lai-Hao Wang et al.. Sensors (Basel). 2017. Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor. doi:10.3390/s17020383 PubMed
- [14] Xingzhong Jin et al.. Cochrane Database Syst Rev. 2016. Ganoderma lucidum (Reishi mushroom) for cancer treatment. doi:10.1002/14651858.CD007731.pub3 PubMed
- [15] S K Jain et al.. Eur J Clin Nutr. 2014. Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type … doi:10.1038/ejcn.2014.114 PubMed
- [16] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
- [17] Priya Batra et al.. Int J Med Mushrooms. 2013. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. doi:10.1615/intjmedmushr.v15.i2.20 PubMed
- [18] Xingzhong Jin et al.. Cochrane Database Syst Rev. 2012. Ganoderma lucidum (Reishi mushroom) for cancer treatment. doi:10.1002/14651858.CD007731.pub2 PubMed
- [19] Xiang-Yu Cui et al.. J Ethnopharmacol. 2012. Extract of Ganoderma lucidum prolongs sleep time in rats. doi:10.1016/j.jep.2011.12.020 PubMed
- [20] Willem I de Boer et al.. Int J Chron Obstruct Pulmon Dis. 2007. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. PubMed
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