Nấm Linh Chi cho Mất Ngủ
C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.Dựa trên 8 nghiên cứu (3 meta-analyses) với 1,374 người tham gia. 8/8 nghiên cứu cho thấy tác động tích cực.
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C
Kết luận
Reishi mushroom shows promising and consistent evidence suggesting it may help support better sleep for people with insomnia.
- All 8 studies (including 3 meta-analyses) report positive effects — unusually consistent
- 1,374 total participants across available research
- Contains compounds identified as having sedative-hypnotic properties
- Evidence base is smaller but growing — more large-scale trials would be valuable
Key Study Findings
In Vitro
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in …
Dose: None
so với: MIN6 cells without NAC
Outcome: Beta cell insulin secretion and signaling
Hiệu quả: None
p<0.05
Đối tượng nghiên cứu: MIN6 beta cell line
Other
Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular …
Dose: None
so với: None
Outcome: Muscle healthspan and calcium regulation
Hiệu quả: None
None
Đối tượng nghiên cứu: C. elegans DMD model
Other
The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris.
Dose: None
so với: None
Outcome: the production of HSA-pFSHβ
Hiệu quả: or 1
None
Đối tượng nghiên cứu: None
Other
Involvement of L-Cysteine Desulfhydrase and Hydrogen Sulfide in Glutathione-Induced Tolerance to Salinity by Accelerating Ascorbate-Glutathione …
Dose: None
so với: None
Outcome: role of L-cysteine desulfhydrase (L-DES) and endogenous hydrogen …
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Other
Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a …
Dose: None
so với: None
Outcome: electrochemical detection of selenomethionine
Hiệu quả: None
None
Đối tượng nghiên cứu: Analytical chemistry (selenium supplement analysis)
Controlled Clinical Trial
n=79
Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels …
Dose: None
so với: healthy controls
Outcome: None
Hiệu quả: None
P=0.05
Đối tượng nghiên cứu: type 2 diabetes patients
Key Statistics
9
Nghiên cứu
79
Người tham gia
↑
Positive
C
Xếp hạng
Referenced Papers
Phytomedicine : international …
2025
1 trích dẫn
Cell and tissue …
2025
Archives of medical …
2025
Phytomedicine : international …
2024
9 trích dẫn
Frontiers in pharmacology
2024
4 trích dẫn
Integrative medicine research
2024
2 trích dẫn
Cureus
2023
16 trích dẫn
Communications biology
2022
14 trích dẫn
Yeast (Chichester, England)
2021
6 trích dẫn
Antioxidants (Basel, Switzerland)
2020
30 trích dẫn
Nutrients
2019
43 trích dẫn
Cellular and molecular …
2019
12 trích dẫn
Sensors (Basel, Switzerland)
2017
5 trích dẫn
The Cochrane database …
2016
10 trích dẫn
European journal of …
2014
77 trích dẫn
Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine.
Review
Journal of immunological …
2014
13 trích dẫn
International journal of …
2013
104 trích dẫn
The Cochrane database …
2012
Journal of ethnopharmacology
2012
International journal of …
2007
56 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- sleep:
- 1,000-3,000 mg extract, before bed
Giới hạn trên: Not established
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 79 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Thời điểm dùng tốt nhất: 1-2 hours before bed
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ GI upset
- ⚠ Dizziness
- ⚠ Dry mouth
- ⚠ Nosebleeds (rare)
Tương tác đã biết
- ● Blood thinners — reishi may increase bleeding risk
- ● Immunosuppressants — reishi may stimulate immune function
- ● Antihypertensives — may lower blood pressure further
Mức hấp thụ tối đa cho phép: Not established
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Nấm Linh Chi help with Mất Ngủ?
Based on 9 studies with 79 participants, there is limited but promising evidence that Nấm Linh Chi may support Mất Ngủ management. Our evidence grade is C (Some Evidence).
How much Nấm Linh Chi should I take for Mất Ngủ?
Studies have used various dosages. A commonly studied range is 1,000-3,000 mg extract, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Nấm Linh Chi?
Reported side effects may include GI upset, Dizziness, Dry mouth, Nosebleeds (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Nấm Linh Chi and Mất Ngủ?
We rate the evidence as Grade C (Some Evidence). This rating is based on 9 peer-reviewed studies with 79 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Mất Ngủ
References
- [1] Wei Chen et al.. Phytomedicine. 2025. Sedative-hypnotic effects of an herbal formulation comprising Ganoderma, Gastrodiae Rhizoma, and Chrysanthemi Flos in mice. doi:10.1016/j.phymed.2025.157374 PubMed
- [2] Meg Schuurman et al.. Cell Tissue Res. 2025. The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells. doi:10.1007/s00441-025-04020-x PubMed
- [3] Xu Wang et al.. Arch Med Sci. 2025. Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine. doi:10.5114/aoms/207509 PubMed
- [4] Wei Chen et al.. Phytomedicine. 2024. Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. doi:10.1016/j.phymed.2024.155355 PubMed
- [5] Yu Qin et al.. Front Pharmacol. 2024. Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease. doi:10.3389/fphar.2024.1390294 PubMed
- [6] Xiaotong Li et al.. Integr Med Res. 2024. Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients. doi:10.1016/j.imr.2024.101089 PubMed
- [7] Nguyen Huu Lac Thuy et al.. Cureus. 2023. Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review. doi:10.7759/cureus.44574 PubMed
- [8] Rebecca A Ellwood et al.. Commun Biol. 2022. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. doi:10.1038/s42003-022-04212-z PubMed
- [9] Gang Luo et al.. Yeast. 2021. The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris. doi:10.1002/yea.3668 PubMed
- [10] Cengiz Kaya et al.. Antioxidants (Basel). 2020. Involvement of L-Cysteine Desulfhydrase and Hydrogen Sulfide in Glutathione-Induced Tolerance to Salinity by Accelerating Ascorbate-Glutathione Cycle and Glyoxalase System in … doi:10.3390/antiox9070603 PubMed
- [11] Feiya Sheng et al.. Nutrients. 2019. Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo. doi:10.3390/nu12010085 PubMed
- [12] Xia Feng et al.. Cell Mol Biol (Noisy-le-grand). 2019. Anti-inflammatory, anti-nociceptive and sedative-hypnotic activities of lucidone D extracted from Ganoderma lucidum. PubMed
- [13] Lai-Hao Wang et al.. Sensors (Basel). 2017. Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor. doi:10.3390/s17020383 PubMed
- [14] Xingzhong Jin et al.. Cochrane Database Syst Rev. 2016. Ganoderma lucidum (Reishi mushroom) for cancer treatment. doi:10.1002/14651858.CD007731.pub3 PubMed
- [15] S K Jain et al.. Eur J Clin Nutr. 2014. Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type … doi:10.1038/ejcn.2014.114 PubMed
- [16] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
- [17] Priya Batra et al.. Int J Med Mushrooms. 2013. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. doi:10.1615/intjmedmushr.v15.i2.20 PubMed
- [18] Xingzhong Jin et al.. Cochrane Database Syst Rev. 2012. Ganoderma lucidum (Reishi mushroom) for cancer treatment. doi:10.1002/14651858.CD007731.pub2 PubMed
- [19] Xiang-Yu Cui et al.. J Ethnopharmacol. 2012. Extract of Ganoderma lucidum prolongs sleep time in rats. doi:10.1016/j.jep.2011.12.020 PubMed
- [20] Willem I de Boer et al.. Int J Chron Obstruct Pulmon Dis. 2007. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. PubMed
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