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Axit Béo Omega-3 cho Mất Ngủ

A

Dựa trên 93 nghiên cứu (9 meta-analyses, 18 RCTs) với 37,338 người tham gia. 67/93 nghiên cứu cho thấy tác động tích cực.

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A

Kết luận

Omega-3 fatty acids are supported by a large body of research suggesting they may help improve sleep quality, particularly for people whose sleep issues are connected to inflammation or mood.

  • 93 studies with 37,338 participants — a very large evidence base
  • 9 meta-analyses and 18 RCTs provide strong, high-quality evidence
  • About 72% of studies show positive effects on sleep
  • May work through anti-inflammatory pathways and support of serotonin/melatonin production

Key Study Findings

animal experimental study
Lavender improves sleep through olfactory perception and GABAergic neurons of the central amygdala.
Dose: LEO 25.0% concentration via inhalation during light phase so với: Placebo Hiệu quả: LEO 25% significantly shortened NREM sleep latency, increased NREM sleep, decreased wakefulness; com None
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL so với: Placebo Hiệu quả: None None
review
Unraveling the connection between the Mediterranean diet and sleep health: from biological mechanisms to clinical …
Dose: Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components so với: Placebo Hiệu quả: None None
review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral so với: Placebo Hiệu quả: None None
RCT n=90 12 weeks Double-blind
A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep …
Dose: 125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily so với: Placebo Hiệu quả: None < 0.05
Case Report n=1
Unmasking Potential Withdrawal Effects of Ashwagandha: A Case Report and Review.
Dose: Ashwagandha extract 600 mg/day (prior to discontinuation) so với: Placebo Hiệu quả: None None

Key Statistics

93

Nghiên cứu

37338

Người tham gia

Positive

A

Xếp hạng

Referenced Papers

Naunyn-Schmiedeberg's archives of … 2025 4 trích dẫn
Journal of ethnopharmacology 2024 6 trích dẫn
International journal of … 2023 43 trích dẫn
Child and adolescent … 2023 5 trích dẫn
Neurologia 2022 78 trích dẫn
Neurologia 2022 47 trích dẫn
Journal of ethnopharmacology 2020 85 trích dẫn
Nutrients 2020 56 trích dẫn
The Cochrane database … 2019 24 trích dẫn
Journal of biotechnology 2017 25 trích dẫn
Annual review of … 2016 557 trích dẫn
Sleep medicine reviews 2015 152 trích dẫn
The Cochrane database … 2014 131 trích dẫn
Biological & pharmaceutical … 2014 110 trích dẫn
The Cochrane database … 2014 56 trích dẫn
Child and adolescent … 2014 42 trích dẫn
Profiles of drug … 2013 26 trích dẫn
Journal of pineal … 2012 322 trích dẫn
Anaesthesia and intensive … 2011 18 trích dẫn
Molecular medicine reports 2010 398 trích dẫn
Phytomedicine : international … 2010 148 trích dẫn
Journal of psychopharmacology … 2005 176 trích dẫn
Prescrire international 2005 2 trích dẫn
Nutrition journal 2004 72 trích dẫn
Revista de neurologia 2002 35 trích dẫn
Psychosomatic medicine 1999 136 trích dẫn
Postgraduate medical journal 1998 17 trích dẫn
American family physician 1997
Electroencephalography and clinical … 1984 2 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

sleep:
600-1,000 mg DHA/day
general:
250-500 mg EPA+DHA/day

Giới hạn trên: 3,000 mg/day EPA+DHA

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
LEO 25.0% concentration via inhalation during light phase -- Positive --
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
Mediterranean diet (high adherence vs. low adherence); polyphenols, omega-3, fiber as key components -- Positive --
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral -- Positive --
125 mg Zenroot (Ashwagandha with 1.5% total withanolides) daily 12 weeks Positive 90
Ashwagandha extract 600 mg/day (prior to discontinuation) -- Negative 1
Not applicable (Mendelian randomization using genetic instruments/SNPs) -- Positive --
600 mg/day (median) 8 weeks Positive 713

Thời điểm dùng tốt nhất: With a meal; morning or evening

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Fishy aftertaste or burps
  • GI upset
  • Diarrhea
  • Easy bruising at high doses

Tương tác đã biết

  • Blood thinners (warfarin) — omega-3 may enhance anticoagulant effects
  • Blood pressure medications — additive hypotensive effects
  • Orlistat — may reduce omega-3 absorption

Mức hấp thụ tối đa cho phép: 3,000 mg/day EPA+DHA

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Axit Béo Omega-3 help with Mất Ngủ?
Based on 93 studies with 37,338 participants, there is strong evidence from multiple clinical trials that Axit Béo Omega-3 may support Mất Ngủ management. Our evidence grade is A (Strong Evidence).
How much Axit Béo Omega-3 should I take for Mất Ngủ?
Studies have used various dosages. A commonly studied range is 600-1,000 mg DHA/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Axit Béo Omega-3?
Reported side effects may include Fishy aftertaste or burps, GI upset, Diarrhea, Easy bruising at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Axit Béo Omega-3 and Mất Ngủ?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 93 peer-reviewed studies with 37,338 total participants. The overall direction of effect is positive.

Related Evidence

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.