Vitamina D per Insonnia

Basato su 53 studi (3 meta-analyses, 1 RCT) con 685,942 partecipanti totali. I risultati sono contrastanti tra gli studi.

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In sintesi

The evidence on vitamin D for insomnia is mixed — low vitamin D levels are associated with poor sleep, but taking vitamin D supplements does not consistently improve insomnia symptoms.

53 studies with 685,942 participants, though mostly from observational research
Low vitamin D levels are associated with poor sleep in population studies
Supplementation results are inconsistent — not a reliable standalone sleep aid
May be most relevant for people who are vitamin D deficient

Key Study Findings

review

Vitamin D and Sleep Disorders.

Dose: None vs: Placebo Effetto: None None

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None vs: Placebo Effetto: None None

review

Nutritional Supplements for Healthy Aging: A Critical Analysis Review.

Dose: None vs: Placebo Effetto: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Effetto: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Effetto: None None

systematic review and meta-analysis

Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.

Dose: None vs: Placebo Effetto: None None

Key Statistics

Studi

685966

Partecipanti

↔

Mixed

Grado

Referenced Papers

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Vitamin D and Sleep Disorders. Review

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Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study. Other

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Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Review

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Vitamin D deficiency and its potential associations on the health status of older patients with chronic obstructive pulmonary disease in … Other

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Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: … Other

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Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis. Systematic Review

Frontiers in neurology 2025 1 citazioni

The synergistic interaction of vitamin D deficiency and insomnia on dizziness-related handicap in patients with benign paroxysmal positional vertigo. Other

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Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to … Other

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A multimodal data-based diagnostic model for predicting vestibular migraine: a retrospective study. Other

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Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study. Other

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Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review. Case Report

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[Nutrition in improving sleep quality and fighting insomnia]. Review

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Corrigendum: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2025

Beyond bone health: mental and sleep health consequences of vitamin D deficiency in emerging adulthood-findings from a large-scale university study. Other

Psychology, health & … 2025

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Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

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Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia. Case Report

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A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases. Review

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Clinical and genetic associations for night eating syndrome in a patient biobank. Other

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Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. Other

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Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study. Other

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[Advances in Mendelian randomization studies on autism spectrum disorder]. Review

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Commentary: The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the … Other

Frontiers in nutrition 2024

Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Meta-Analysis

Psychiatry and clinical … 2023 67 citazioni

Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance. Other

International journal of … 2023 19 citazioni

Sleep Patterns Modify the Association between Vitamin D Status and Coronary Heart Disease: Results from NHANES 2005-2008. Other

The Journal of … 2023 9 citazioni

Integrative Approaches in the Treatment of Patients Affected by Lymphoma. Review

Current oncology reports 2023 5 citazioni

Complementary and Integrative Approaches to Sleep Disorders in Children. Review

Child and adolescent … 2023 5 citazioni

Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Case Report

Frontiers in neurology 2023 3 citazioni

The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United … Other

Frontiers in nutrition 2023 3 citazioni

Early risk assessment and prediction model for osteoporosis based on traditional Chinese medicine syndromes. Other

Heliyon 2023 3 citazioni

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 citazioni

Top 20 Research Studies of 2022 for Primary Care Physicians. Other

American family physician 2023

Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety. Other

Human brain mapping 2023

Digital Addiction and Sleep. Review

International journal of … 2022 107 citazioni

The Role of Vitamin D in Sleep Disorders of Children and Adolescents: A Systematic Review. Systematic Review

International journal of … 2022 36 citazioni

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 citazioni

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 citazioni

Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review. Systematic Review

Pharmacological research 2022 9 citazioni

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 citazioni

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 citazioni

The use of dietary supplements for mental health among the Saudi population: A cross-sectional survey. Other

Saudi pharmaceutical journal … 2022 4 citazioni

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 citazioni

Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Other

Sleep medicine: X 2022 2 citazioni

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. Other

International journal of … 2021 25 citazioni

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 citazioni

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 citazioni

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Other

Sleep medicine: X 2021 9 citazioni

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls. Other

Basic and clinical … 2021 2 citazioni

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. Review

Journal of neural … 2020 194 citazioni

Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank … Other

Diabetes care 2020 110 citazioni

Quality of life of patients more than 1 year after surgery for thyroid cancer. Other

Hormones (Athens, Greece) 2020 20 citazioni

Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D3 on improvement in symptoms of insomnia and quality of … Other

Food science & … 2020 17 citazioni

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 citazioni

Relationship Between Nutritional Status and Insomnia Severity in Older Adults. Other

Journal of the … 2019 58 citazioni

Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Review

Expert opinion on … 2019 49 citazioni

Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Other

Acta neurologica Scandinavica 2019 36 citazioni

Association between Vitamin D Status and Premenstrual Symptoms. Other

Journal of the … 2019 16 citazioni

Sleep and biological parameters in professional burnout: A psychophysiological characterization. Other

PloS one 2018 69 citazioni

Complement systems C4, C3 and CH50 not subject to a circadian rhythm. Other

Diagnosis (Berlin, Germany) 2018 4 citazioni

Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. Other

Clinica chimica acta; … 2017 14 citazioni

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … Other

Medical hypotheses 2016 105 citazioni

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

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Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults. Other

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Effects of a phyto complex on well-being of climacteric women. Observational

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Viscum album (mistletoe) for pancreatic cancer, electromagnetic field therapy for osteoarthritis, homeopathy for multidrug-resistant tuberculosis, vitamin D for depression, acupuncture … Other

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Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia? Other

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Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Other

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Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 600-800 IU/day
deficiency:: 1,000-5,000 IU/day

Limite massimo: 4,000 IU/day

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: Morning with a meal containing fat; avoid evening dosing

Safety & Side Effects

Effetti collaterali segnalati

⚠ Hypercalcemia at high doses
⚠ Nausea
⚠ Constipation
⚠ Kidney stones (rare, with excessive intake)

Interazioni note

● Corticosteroids — reduce calcium absorption, affecting vitamin D metabolism
● Weight-loss drugs (orlistat) — may reduce vitamin D absorption
● Statins — vitamin D may affect statin metabolism

Livello di assunzione massimo tollerabile: 4,000 IU/day

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Vitamina D help with Insonnia?

Based on 56 studies with 685,966 participants, there is strong evidence from multiple clinical trials that Vitamina D may support Insonnia management. Our evidence grade is A (Strong Evidence).

How much Vitamina D should I take for Insonnia?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamina D?

Reported side effects may include Hypercalcemia at high doses, Nausea, Constipation, Kidney stones (rare, with excessive intake). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamina D and Insonnia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 56 peer-reviewed studies with 685,966 total participants. The overall direction of effect is mixed.

Related Evidence

Altri ingredienti per Insonnia

Melatonin A Radice di valeriana A CBD A Acidi grassi Omega-3 A Triptofano A Lavanda A

Vitamina D per altre condizioni

Insonnia da mantenimento del sonno D

Verdetto rapido

Basato su 53 studi (3 meta-analyses, 1 RCT) con 685,942 partecipanti totali. I risultati sono contrastanti tra gli studi.

Evidence Strength92%

High confidence

Analisi degli studi

RCT (5)Meta (1)Other (50)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Insonnia

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.