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L-Ornithine per Insonnia

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Based on 2 studies (1 RCT). 2/2 studies show positive effects.

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            C

        

        

            
In sintesi

            
            
Based on 2 studies (1 RCT). 2/2 studies show positive effects.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                8.0 weeks
                
                
                Double-blind
                
            

            
                Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in …
            
            

                
                Dose: 400 mg/day
                
                
                vs: placebo
                
                
                Outcome: None
                
                
                Effetto: None
                
                
                None
                
            

            
            
Popolazione: healthy subjects

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Strategies of Functional Foods Promote Sleep in Human Being.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Sleep quality and insomnia prevention
                
                
                Effetto: None
                
                
                None
                
            

            
            
Popolazione: Adults with insomnia or sleep disorders

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Studi

    

    

        
--

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grado

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrition journal
                        2014
                        
                        76 citazioni
                        
                    

                

                
                

                    

                        
                            Strategies of Functional Foods Promote Sleep in Human Being.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Current signal transduction …
                        2014
                        
                        41 citazioni
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
sleep:

                        
400-800 mg, 30-60 min before bed

                    

                    
                

                
                

                    Limite massimo: Not formally established; 6,000 mg/day used in exercise studies
                

                
            

            

            
            

                
Dosaggi studiati nella ricerca

                

                    

                        
                            

                                Dosaggio
                                Durata
                                Effetto
                                N
                            

                        
                        
                            
                            

                                400 mg/day
                                8.0 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Momento migliore per l'assunzione: 30-60 minutes before bed on an empty stomach
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            GI discomfort at high doses (diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia at very high doses (paradoxical in some individuals)
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Growth hormone secretagogues — ornithine may stimulate GH release
                        
    • 
                        
                        
  • 
                            ●
                            Arginine supplements — metabolic interaction (urea cycle)
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: Not formally established; 6,000 mg/day used in exercise studies
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Ornithine help with Insonnia?
            
        
        

            Based on 2 studies with 0 participants, there is limited but promising evidence that L-Ornithine may support Insonnia management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Ornithine should I take for Insonnia?
            
        
        

            Studies have used various dosages. A commonly studied range is 400-800 mg, 30-60 min before bed. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Ornithine?
            
        
        

            Reported side effects may include GI discomfort at high doses (diarrhea), Insomnia at very high doses (paradoxical in some individuals). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Ornithine and Insonnia?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
L-Ornithine per altre condizioni

                    

                        
                        
                            Disturbo del sonno da lavoro a turni
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Mika Miyake et al..
      Nutr J.
      2014.
      Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.
      doi:10.1186/1475-2891-13-53
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Yawen Zeng et al..
      Curr Signal Transduct Ther.
      2014.
      Strategies of Functional Foods Promote Sleep in Human Being.
      doi:10.2174/1574362410666150205165504
      PubMed
    
    3. 
    
  















    

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