Vitamina B6 per Insonnia

Basato su 5 studi (1 RCT) con 50 partecipanti totali. 3/5 studi mostrano effetti positivi.

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In sintesi

Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.

Only 5 studies with 50 total participants — evidence is preliminary
B6 is involved in producing serotonin and melatonin, both important for sleep
Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
More clinical trials with larger sample sizes are needed

Key Study Findings

Other

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.

Dose: None vs: None Outcome: Causal association of nutrients with insomnia Effetto: Magnesium OR 0.869 (95% CI 0.763-0.990) P<0.05

Popolazione: FinnGen insomnia GWAS population

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Effetto: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Effetto: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

prospective single-arm open-label pilot study n=40 4 weeks Open-label

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …

Dose: not specified per component vs: Placebo Effetto: mean sleep quality +1.9 points p < 0.001

Review

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Crohn's disease patients (micronutrient deficiency)

Review

Strategies of Functional Foods Promote Sleep in Human Being.

Dose: None vs: None Outcome: Sleep quality and insomnia prevention Effetto: None None

Popolazione: Adults with insomnia or sleep disorders

Key Statistics

Studi

Partecipanti

↑

Positive

Grado

Referenced Papers

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen. Other

Psychiatry and clinical … 2025

A genome-wide methylation analysis of Chinese Han patients with chronic insomnia disorder. Other

Sleep & breathing … 2024

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 citazioni

Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial. RCT

Nutrients 2017 27 citazioni

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 citazioni

Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg. Other

Neurological sciences : … 2014 58 citazioni

Strategies of Functional Foods Promote Sleep in Human Being. Other

Current signal transduction … 2014 41 citazioni

Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Other

Journal of child … 2013 18 citazioni

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citazioni

Kidney damage in acute intermittent porphyria. Other

Przeglad lekarski 2011

Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Other

Climacteric : the … 2006

Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Review

Seminars in thrombosis … 2000 194 citazioni

Nutritional factors in the etiology of the premenstrual tension syndromes. Other

The Journal of … 1983

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

sleep:: 25-50 mg with B-complex
general:: 1.3-1.7 mg/day

Limite massimo: 100 mg/day (neuropathy risk above)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
not specified per component	4 weeks	Positive	40
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
5 mg	--	Mixed	--

Momento migliore per l'assunzione: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

Effetti collaterali segnalati

⚠ Nausea
⚠ Peripheral neuropathy at high doses (>100 mg/day)
⚠ Vivid dreams
⚠ Heartburn

Interazioni note

● Levodopa — B6 may reduce effectiveness (without carbidopa)
● Phenobarbital and phenytoin — B6 may reduce serum levels
● Cycloserine — B6 deficiency may worsen side effects

Livello di assunzione massimo tollerabile: 100 mg/day (neuropathy risk above)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Vitamina B6 help with Insonnia?

Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that Vitamina B6 may support Insonnia management. Our evidence grade is B (Good Evidence).

How much Vitamina B6 should I take for Insonnia?

Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamina B6?

Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamina B6 and Insonnia?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Insonnia

Melatonin A Radice di valeriana A CBD A Acidi grassi Omega-3 A Triptofano A Vitamina D A

Vitamina B6 per altre condizioni

Difficoltà di addormentamento A

Verdetto rapido

Basato su 5 studi (1 RCT) con 50 partecipanti totali. 3/5 studi mostrano effetti positivi.

Evidence Strength72%

High confidence

Analisi degli studi

RCT (1)Meta (0)Other (7)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Insonnia

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.