Vitamina B6 para Insomnio

Basado en 5 estudios (1 RCT) con 50 participantes en total. 3/5 estudios muestran efectos positivos.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'sleepcited.com'; const params = 'ingredient\u003Dvitamin\u002Db6\u0026condition\u003Dinsomnia'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Conclusión

Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.

Only 5 studies with 50 total participants — evidence is preliminary
B6 is involved in producing serotonin and melatonin, both important for sleep
Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
More clinical trials with larger sample sizes are needed

Key Study Findings

Other

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.

Dose: None vs: None Outcome: Causal association of nutrients with insomnia Efecto: Magnesium OR 0.869 (95% CI 0.763-0.990) P<0.05

Población: FinnGen insomnia GWAS population

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Efecto: None None

Mendelian randomization

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Dose: None vs: Placebo Efecto: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.

prospective single-arm open-label pilot study n=40 4 weeks Open-label

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …

Dose: not specified per component vs: Placebo Efecto: mean sleep quality +1.9 points p < 0.001

Review

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?

Dose: None vs: None Outcome: None Efecto: None None

Población: Crohn's disease patients (micronutrient deficiency)

Review

Strategies of Functional Foods Promote Sleep in Human Being.

Dose: None vs: None Outcome: Sleep quality and insomnia prevention Efecto: None None

Población: Adults with insomnia or sleep disorders

Key Statistics

Estudios

Participantes

↑

Positive

Calificación

Referenced Papers

Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. Other

Medicine 2025

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. Other

Brain and behavior 2025

A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen. Other

Psychiatry and clinical … 2025

A genome-wide methylation analysis of Chinese Han patients with chronic insomnia disorder. Other

Sleep & breathing … 2024

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Other

Complementary therapies in … 2019 26 citas

Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial. RCT

Nutrients 2017 27 citas

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 citas

Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg. Other

Neurological sciences : … 2014 58 citas

Strategies of Functional Foods Promote Sleep in Human Being. Other

Current signal transduction … 2014 41 citas

Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. Other

Journal of child … 2013 18 citas

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citas

Kidney damage in acute intermittent porphyria. Other

Przeglad lekarski 2011

Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Other

Climacteric : the … 2006

Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Review

Seminars in thrombosis … 2000 194 citas

Nutritional factors in the etiology of the premenstrual tension syndromes. Other

The Journal of … 1983

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

sleep:: 25-50 mg with B-complex
general:: 1.3-1.7 mg/day

Límite superior: 100 mg/day (neuropathy risk above)

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Mixed	--
not specified per component	4 weeks	Positive	40
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
5 mg	--	Mixed	--

Mejor momento para tomar: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

Efectos secundarios reportados

⚠ Nausea
⚠ Peripheral neuropathy at high doses (>100 mg/day)
⚠ Vivid dreams
⚠ Heartburn

Interacciones conocidas

● Levodopa — B6 may reduce effectiveness (without carbidopa)
● Phenobarbital and phenytoin — B6 may reduce serum levels
● Cycloserine — B6 deficiency may worsen side effects

Ingesta máxima tolerable: 100 mg/day (neuropathy risk above)

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Vitamina B6 help with Insomnio?

Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that Vitamina B6 may support Insomnio management. Our evidence grade is B (Good Evidence).

How much Vitamina B6 should I take for Insomnio?

Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamina B6?

Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamina B6 and Insomnio?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Insomnio

Melatonin A Raíz de Valeriana A CBD A Ácidos Grasos Omega-3 A Tryptophan A Vitamina D A

Vitamina B6 para otras condiciones

Dificultad para Conciliar el Sueño A

Veredicto rápido

Basado en 5 estudios (1 RCT) con 50 participantes en total. 3/5 estudios muestran efectos positivos.

Evidence Strength72%

High confidence

Desglose de estudios

RCT (1)Meta (0)Other (7)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Insomnio

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.