Vitamin B6 के लिए अनिद्रा
B संबंधित साक्ष्य कम से कम एक यादृच्छिक परीक्षण इसका समर्थन करता है, जिसके परिणाम अधिकतर सुसंगत हैं।5 अध्ययनों (1 RCT) पर आधारित, में कुल 50 प्रतिभागियों के साथ। 3/5 अध्ययन सकारात्मक प्रभाव दिखाते हैं।
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B
निष्कर्ष
Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.
- Only 5 studies with 50 total participants — evidence is preliminary
- B6 is involved in producing serotonin and melatonin, both important for sleep
- Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
- More clinical trials with larger sample sizes are needed
Key Study Findings
Other
Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.
Dose: None
बनाम: None
Outcome: Causal association of nutrients with insomnia
प्रभाव: Magnesium OR 0.869 (95% CI 0.763-0.990)
P<0.05
जनसंख्या: FinnGen insomnia GWAS population
review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral
बनाम: Placebo
प्रभाव: None
None
Mendelian randomization
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.
Dose: None
बनाम: Placebo
प्रभाव: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96)
Folate p=0.02; Vitamin B6 p=1.
prospective single-arm open-label pilot study
n=40
4 weeks
Open-label
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …
Dose: not specified per component
बनाम: Placebo
प्रभाव: mean sleep quality +1.9 points
p < 0.001
Review
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: Crohn's disease patients (micronutrient deficiency)
Review
Strategies of Functional Foods Promote Sleep in Human Being.
Dose: None
बनाम: None
Outcome: Sleep quality and insomnia prevention
प्रभाव: None
None
जनसंख्या: Adults with insomnia or sleep disorders
Key Statistics
8
अध्ययन
40
प्रतिभागी
↑
Positive
B
ग्रेड
Referenced Papers
Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.
Other
Medicine
2025
Nutricion hospitalaria
2025
Brain and behavior
2025
A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen.
Other
Psychiatry and clinical …
2025
Sleep & breathing …
2024
Complementary therapies in …
2019
26 उद्धरण
Nutrients
2017
27 उद्धरण
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Review
Digestive diseases (Basel, …
2016
41 उद्धरण
Neurological sciences : …
2014
58 उद्धरण
Current signal transduction …
2014
41 उद्धरण
Journal of child …
2013
18 उद्धरण
European journal of …
2012
225 उद्धरण
Przeglad lekarski
2011
Climacteric : the …
2006
Seminars in thrombosis …
2000
194 उद्धरण
The Journal of …
1983
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- sleep:
- 25-50 mg with B-complex
- general:
- 1.3-1.7 mg/day
अधिकतम सीमा: 100 mg/day (neuropathy risk above)
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Positive | -- |
| tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral | -- | Positive | -- |
| None | -- | Mixed | -- |
| not specified per component | 4 weeks | Positive | 40 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 5 mg | -- | Mixed | -- |
सेवन का सर्वोत्तम समय: Morning or with dinner; high doses before bed may increase dream vividness
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Nausea
- ⚠ Peripheral neuropathy at high doses (>100 mg/day)
- ⚠ Vivid dreams
- ⚠ Heartburn
ज्ञात अंतःक्रियाएँ
- ● Levodopa — B6 may reduce effectiveness (without carbidopa)
- ● Phenobarbital and phenytoin — B6 may reduce serum levels
- ● Cycloserine — B6 deficiency may worsen side effects
सहनीय अधिकतम सेवन: 100 mg/day (neuropathy risk above)
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Vitamin B6 help with अनिद्रा?
Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that Vitamin B6 may support अनिद्रा management. Our evidence grade is B (Good Evidence).
How much Vitamin B6 should I take for अनिद्रा?
Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin B6?
Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin B6 and अनिद्रा?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री अनिद्रा
Vitamin B6 अन्य स्वास्थ्य स्थितियों के लिए
References
- [1] Lei Luo et al.. Medicine (Baltimore). 2025. Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. doi:10.1097/MD.0000000000046075 PubMed
- [2] Rosa M Ortega et al.. Nutr Hosp. 2025. [Nutrition in improving sleep quality and fighting insomnia]. doi:10.20960/nh.06090 PubMed
- [3] Ruijie Zhang et al.. Brain Behav. 2025. Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study. doi:10.1002/brb3.70237 PubMed
- [4] Jingfeng Lin et al.. Psychiatry Clin Psychopharmacol. 2025. A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen. doi:10.5152/pcp.2025.24923 PubMed
- [5] Xiao Li et al.. Sleep Breath. 2024. A genome-wide methylation analysis of Chinese Han patients with chronic insomnia disorder. doi:10.1007/s11325-024-03145-7 PubMed
- [6] Patrick Lemoine et al.. Complement Ther Med. 2019. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. doi:10.1016/j.ctim.2019.05.024 PubMed
- [7] Andrew Scholey et al.. Nutrients. 2017. Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial. doi:10.3390/nu9020154 PubMed
- [8] Wolfgang Kruis et al.. Dig Dis. 2016. Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? doi:10.1159/000443012 PubMed
- [9] D Dalla Libera et al.. Neurol Sci. 2014. Complementary and alternative medicine (CAM) use in an Italian cohort of pediatric headache patients: the tip of the iceberg. doi:10.1007/s10072-014-1756-y PubMed
- [10] Yawen Zeng et al.. Curr Signal Transduct Ther. 2014. Strategies of Functional Foods Promote Sleep in Human Being. doi:10.2174/1574362410666150205165504 PubMed
- [11] Elisabeth A Frazier et al.. J Child Adolesc Psychopharmacol. 2013. Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders. doi:10.1089/cap.2012.0098 PubMed
- [12] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [13] Miroslav Mydlík et al.. Przegl Lek. 2011. Kidney damage in acute intermittent porphyria. PubMed
- [14] H Hachul de Campos et al.. Climacteric. 2006. Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. doi:10.1080/13697130600871947 PubMed
- [15] R Clarke et al.. Semin Thromb Hemost. 2000. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. doi:10.1055/s-2000-8101 PubMed
- [16] G E Abraham. J Reprod Med. 1983. Nutritional factors in the etiology of the premenstrual tension syndromes. PubMed
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।