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SleepCited

Vitamina B6 para Insônia

B

Baseado em 5 estudos (1 RCT) com 50 participantes no total. 3/5 estudos mostram efeitos positivos.

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B

Conclusão

Vitamin B6 may play a role in supporting sleep through its involvement in melatonin production, but the direct evidence for insomnia is limited and preliminary.

  • Only 5 studies with 50 total participants — evidence is preliminary
  • B6 is involved in producing serotonin and melatonin, both important for sleep
  • Genetic studies (Mendelian randomization) suggest a link between B6 and sleep behaviors
  • More clinical trials with larger sample sizes are needed

Key Study Findings

Other
Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.
Dose: None vs: None Outcome: Causal association of nutrients with insomnia Efeito: Magnesium OR 0.869 (95% CI 0.763-0.990) P<0.05

População: FinnGen insomnia GWAS population

review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo Efeito: None None
Mendelian randomization
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.
Dose: None vs: Placebo Efeito: Folate vs chronotype OR 1.09 (95% CI 1.01-1.17); Vitamin B6 vs chronotype OR 0.91 (95% CI 0.86-0.96) Folate p=0.02; Vitamin B6 p=1.
prospective single-arm open-label pilot study n=40 4 weeks Open-label
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: …
Dose: not specified per component vs: Placebo Efeito: mean sleep quality +1.9 points p < 0.001
Review
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Dose: None vs: None Outcome: None Efeito: None None

População: Crohn's disease patients (micronutrient deficiency)

Review
Strategies of Functional Foods Promote Sleep in Human Being.
Dose: None vs: None Outcome: Sleep quality and insomnia prevention Efeito: None None

População: Adults with insomnia or sleep disorders

Key Statistics

8

Estudos

40

Participantes

Positive

B

Nota

Referenced Papers

Current signal transduction … 2014 41 citações
European journal of … 2012 225 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:
25-50 mg with B-complex
general:
1.3-1.7 mg/day

Limite superior: 100 mg/day (neuropathy risk above)

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive --
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral -- Positive --
None -- Mixed --
not specified per component 4 weeks Positive 40
None -- Mixed --
None -- Positive --
None -- Positive --
5 mg -- Mixed --

Melhor horário: Morning or with dinner; high doses before bed may increase dream vividness

Safety & Side Effects

Efeitos Colaterais Relatados

  • Nausea
  • Peripheral neuropathy at high doses (>100 mg/day)
  • Vivid dreams
  • Heartburn

Interações Conhecidas

  • Levodopa — B6 may reduce effectiveness (without carbidopa)
  • Phenobarbital and phenytoin — B6 may reduce serum levels
  • Cycloserine — B6 deficiency may worsen side effects

Ingestão máxima tolerável: 100 mg/day (neuropathy risk above)

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Vitamina B6 help with Insônia?
Based on 8 studies with 40 participants, there is moderate evidence from clinical studies that Vitamina B6 may support Insônia management. Our evidence grade is B (Good Evidence).
How much Vitamina B6 should I take for Insônia?
Studies have used various dosages. A commonly studied range is 25-50 mg with B-complex. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamina B6?
Reported side effects may include Nausea, Peripheral neuropathy at high doses (>100 mg/day), Vivid dreams, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamina B6 and Insônia?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 40 total participants. The overall direction of effect is positive.

Related Evidence

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.