厚朴皮 用于 失眠
B 证据 至少一项随机试验支持这一结论，结果基本一致。基于3项研究（1项RCT），共723名参与者。3/3项研究显示积极效果。
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B
结论
Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.
- All 3 studies (including 2 RCTs) report positive effects on insomnia
- 723 total participants across the available research
- Most studies used magnolia bark combined with other ingredients
- Research has focused mainly on menopausal women
Key Study Findings
In Vitro
HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …
Dose: None
vs: None
Outcome: GABAA receptor modulator identification
效果: None
None
研究人群: Zebrafish larvae and Xenopus oocytes (in vitro)
randomized_controlled_trial
n=634
12 weeks
Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …
Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t
vs: Placebo
效果: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l
not_reported
Randomized Controlled Trial
n=40
6 weeks
Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …
Dose: 250mg x 3 daily
vs: Identical placebo
Outcome: Effect of a proprietary Magnolia and Phellodendron extract …
效果: None
None
研究人群: This randomized, parallel, placebo controlled clinical study was conducted with
randomized controlled trial
n=89
24 weeks
Open-label
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.
Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma
vs: Placebo
效果: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs
None
Key Statistics
5
研究数量
763
受试者
↑
Positive
B
等级
Referenced Papers
Molecular pharmaceutics
2019
10 次引用
Journal of natural …
2017
27 次引用
Frontiers in pharmacology
2016
15 次引用
Minerva ginecologica
2011
19 次引用
Medical science monitor …
2009
85 次引用
Nutrition journal
2008
51 次引用
Minerva ginecologica
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- sleep:
- 200-400 mg standardized to 90% honokiol+magnolol
上限： Not established
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t | 12 weeks | Positive | 634 |
| 250mg x 3 daily | 6 weeks | Negative | 40 |
| 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma | 24 weeks | Positive | 89 |
最佳服用时间： 30-60 minutes before bed
Safety & Side Effects
已报告的副作用
- ⚠ Drowsiness
- ⚠ Dizziness
- ⚠ Headache
- ⚠ Heartburn
已知相互作用
- ● Sedatives and alcohol — additive CNS depression
- ● Blood thinners — magnolol may have antiplatelet activity
- ● Antidiabetic drugs — may affect blood glucose levels
可耐受最高摄入量： Not established
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 厚朴皮 help with 失眠?
Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that 厚朴皮 may support 失眠 management. Our evidence grade is B (Good Evidence).
How much 厚朴皮 should I take for 失眠?
Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 厚朴皮?
Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 厚朴皮 and 失眠?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.
Related Evidence
厚朴皮 用于其他健康状况
References
- [1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
- [2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
- [3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
- [4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
- [5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
- [6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
- [7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed
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