목련 껍질 관련 불면증

B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.

총 723명의 참여자를 대상으로 한 3건의 연구(RCT 1건)에 근거합니다. 3건 중 3건의 연구에서 긍정적인 효과가 나타났습니다.

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결론

Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.

All 3 studies (including 2 RCTs) report positive effects on insomnia
723 total participants across the available research
Most studies used magnolia bark combined with other ingredients
Research has focused mainly on menopausal women

Key Study Findings

In Vitro

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …

Dose: None vs: None Outcome: GABAA receptor modulator identification 효과: None None

대상 집단: Zebrafish larvae and Xenopus oocytes (in vitro)

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo 효과: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

Randomized Controlled Trial n=40 6 weeks

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …

Dose: 250mg x 3 daily vs: Identical placebo Outcome: Effect of a proprietary Magnolia and Phellodendron extract … 효과: None None

대상 집단: This randomized, parallel, placebo controlled clinical study was conducted with

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo 효과: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

연구

763

참여자

↑

Positive

등급

Referenced Papers

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. Other

Molecular pharmaceutics 2019 10 인용

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Other

Journal of natural … 2017 27 인용

Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Other

Frontiers in pharmacology 2016 15 인용

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 인용

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 인용

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. RCT

Nutrition journal 2008 51 인용

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

sleep:: 200-400 mg standardized to 90% honokiol+magnolol

상한량: Not established

연구에서 사용된 용량

용량	기간	효과	N
None	--	Mixed	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
250mg x 3 daily	6 weeks	Negative	40
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89

권장 복용 시간: 30-60 minutes before bed

Safety & Side Effects

보고된 부작용

⚠ Drowsiness
⚠ Dizziness
⚠ Headache
⚠ Heartburn

알려진 상호작용

● Sedatives and alcohol — additive CNS depression
● Blood thinners — magnolol may have antiplatelet activity
● Antidiabetic drugs — may affect blood glucose levels

일일 최대 섭취 허용량: Not established

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 목련 껍질 help with 불면증?

Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that 목련 껍질 may support 불면증 management. Our evidence grade is B (Good Evidence).

How much 목련 껍질 should I take for 불면증?

Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 목련 껍질?

Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 목련 껍질 and 불면증?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.

목련 껍질 다른 건강 상태에 대한 근거

불안 관련 수면 문제 C

한눈에 보기

총 723명의 참여자를 대상으로 한 3건의 연구(RCT 1건)에 근거합니다. 3건 중 3건의 연구에서 긍정적인 효과가 나타났습니다.

Evidence Strength72%

High confidence

연구 분석

RCT (3)Meta (0)Other (2)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 불면증

자세히 알아보기

References

[1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
[2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
[3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
[4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
[6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
[7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed

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