マグノリア樹皮：不眠症

B エビデンス少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。

合計723名の参加者を対象とした3件の研究（RCT 1件を含む）に基づく。3件中3件の研究で肯定的な効果が示されている。

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結論

Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.

All 3 studies (including 2 RCTs) report positive effects on insomnia
723 total participants across the available research
Most studies used magnolia bark combined with other ingredients
Research has focused mainly on menopausal women

Key Study Findings

In Vitro

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …

Dose: None vs: None Outcome: GABAA receptor modulator identification 効果: None None

対象集団: Zebrafish larvae and Xenopus oocytes (in vitro)

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo 効果: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

Randomized Controlled Trial n=40 6 weeks

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …

Dose: 250mg x 3 daily vs: Identical placebo Outcome: Effect of a proprietary Magnolia and Phellodendron extract … 効果: None None

対象集団: This randomized, parallel, placebo controlled clinical study was conducted with

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo 効果: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

研究数

763

参加者数

↑

Positive

グレード

Referenced Papers

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. Other

Molecular pharmaceutics 2019 10 件の引用

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Other

Journal of natural … 2017 27 件の引用

Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Other

Frontiers in pharmacology 2016 15 件の引用

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 件の引用

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 件の引用

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. RCT

Nutrition journal 2008 51 件の引用

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:: 200-400 mg standardized to 90% honokiol+magnolol

上限量： Not established

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
250mg x 3 daily	6 weeks	Negative	40
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89

推奨摂取タイミング： 30-60 minutes before bed

Safety & Side Effects

報告されている副作用

⚠ Drowsiness
⚠ Dizziness
⚠ Headache
⚠ Heartburn

既知の相互作用

● Sedatives and alcohol — additive CNS depression
● Blood thinners — magnolol may have antiplatelet activity
● Antidiabetic drugs — may affect blood glucose levels

耐容上限摂取量： Not established

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does マグノリア樹皮 help with 不眠症?

Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that マグノリア樹皮 may support 不眠症 management. Our evidence grade is B (Good Evidence).

How much マグノリア樹皮 should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of マグノリア樹皮?

Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for マグノリア樹皮 and 不眠症?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.

に関する他の成分：不眠症

メラトニン A バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ビタミンD A

マグノリア樹皮他の症状・状態について

不安に伴う睡眠障害 C

総合評価

合計723名の参加者を対象とした3件の研究（RCT 1件を含む）に基づく。3件中3件の研究で肯定的な効果が示されている。

Evidence Strength72%

High confidence

研究の内訳

RCT (3)Meta (0)Other (2)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

詳しく見る

References

[1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
[2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
[3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
[4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
[6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
[7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

マグノリア樹皮 ： 不眠症