Écorce de magnolia pour Insomnie

B Preuves Au moins un essai randomisé le soutient, avec des résultats globalement concordants.

Basé sur 3 études (1 RCT) avec 723 participants au total. 3/3 études montrent des effets positifs.

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En conclusion

Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.

All 3 studies (including 2 RCTs) report positive effects on insomnia
723 total participants across the available research
Most studies used magnolia bark combined with other ingredients
Research has focused mainly on menopausal women

Key Study Findings

In Vitro

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …

Dose: None vs: None Outcome: GABAA receptor modulator identification Effet: None None

Population: Zebrafish larvae and Xenopus oocytes (in vitro)

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo Effet: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

Randomized Controlled Trial n=40 6 weeks

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …

Dose: 250mg x 3 daily vs: Identical placebo Outcome: Effect of a proprietary Magnolia and Phellodendron extract … Effet: None None

Population: This randomized, parallel, placebo controlled clinical study was conducted with

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo Effet: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

Études

763

Participants

↑

Positive

Note

Referenced Papers

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. Other

Molecular pharmaceutics 2019 10 citations

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Other

Journal of natural … 2017 27 citations

Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Other

Frontiers in pharmacology 2016 15 citations

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 citations

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 citations

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. RCT

Nutrition journal 2008 51 citations

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

sleep:: 200-400 mg standardized to 90% honokiol+magnolol

Limite supérieure : Not established

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Mixed	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
250mg x 3 daily	6 weeks	Negative	40
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89

Moment optimal de prise : 30-60 minutes before bed

Safety & Side Effects

Effets indésirables signalés

⚠ Drowsiness
⚠ Dizziness
⚠ Headache
⚠ Heartburn

Interactions connues

● Sedatives and alcohol — additive CNS depression
● Blood thinners — magnolol may have antiplatelet activity
● Antidiabetic drugs — may affect blood glucose levels

Apport maximal tolérable : Not established

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Écorce de magnolia help with Insomnie?

Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that Écorce de magnolia may support Insomnie management. Our evidence grade is B (Good Evidence).

How much Écorce de magnolia should I take for Insomnie?

Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Écorce de magnolia?

Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Écorce de magnolia and Insomnie?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.

Autres ingrédients pour Insomnie

Mélatonine A Racine de valériane A CBD A Acides gras oméga-3 A Tryptophane A Vitamine D A

Écorce de magnolia pour d'autres pathologies

Troubles du Sommeil Liés à l'Anxiété C

Verdict rapide

Basé sur 3 études (1 RCT) avec 723 participants au total. 3/3 études montrent des effets positifs.

Evidence Strength72%

High confidence

Synthèse des études

RCT (3)Meta (0)Other (2)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Insomnie

En savoir plus

References

[1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
[2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
[3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
[4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
[6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
[7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.