Manolya Kabuğu için Uykusuzluk

B Kanıt Bunu büyük ölçüde tutarlı sonuçlarla en az bir randomize çalışma desteklemektedir.

3 çalışmaya (1 RCT), toplam 723 katılımcıyla dayanmaktadır. 3/3 çalışma olumlu etkiler göstermektedir.

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Sonuç

Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.

All 3 studies (including 2 RCTs) report positive effects on insomnia
723 total participants across the available research
Most studies used magnolia bark combined with other ingredients
Research has focused mainly on menopausal women

Key Study Findings

In Vitro

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …

Dose: None vs: None Outcome: GABAA receptor modulator identification Etki: None None

Popülasyon: Zebrafish larvae and Xenopus oocytes (in vitro)

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo Etki: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

Randomized Controlled Trial n=40 6 weeks

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …

Dose: 250mg x 3 daily vs: Identical placebo Outcome: Effect of a proprietary Magnolia and Phellodendron extract … Etki: None None

Popülasyon: This randomized, parallel, placebo controlled clinical study was conducted with

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo Etki: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

Çalışmalar

763

Katılımcılar

↑

Positive

Derece

Referenced Papers

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. Other

Molecular pharmaceutics 2019 10 atıf

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Other

Journal of natural … 2017 27 atıf

Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Other

Frontiers in pharmacology 2016 15 atıf

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 atıf

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 atıf

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. RCT

Nutrition journal 2008 51 atıf

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

sleep:: 200-400 mg standardized to 90% honokiol+magnolol

Üst sınır: Not established

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
None	--	Mixed	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
250mg x 3 daily	6 weeks	Negative	40
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89

En iyi alım zamanı: 30-60 minutes before bed

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Drowsiness
⚠ Dizziness
⚠ Headache
⚠ Heartburn

Bilinen Etkileşimler

● Sedatives and alcohol — additive CNS depression
● Blood thinners — magnolol may have antiplatelet activity
● Antidiabetic drugs — may affect blood glucose levels

Tolere edilebilir üst alım: Not established

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Manolya Kabuğu help with Uykusuzluk?

Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that Manolya Kabuğu may support Uykusuzluk management. Our evidence grade is B (Good Evidence).

How much Manolya Kabuğu should I take for Uykusuzluk?

Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Manolya Kabuğu?

Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Manolya Kabuğu and Uykusuzluk?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.

Şu durum için diğer içerikler: Uykusuzluk

Melatonin A Valerian Kökü A CBD A Omega-3 Yağ Asitleri A Tryptophan A D Vitamini A

Manolya Kabuğu diğer sağlık durumları için

Anksiyeteye Bağlı Uyku Sorunları C

Hızlı Değerlendirme

3 çalışmaya (1 RCT), toplam 723 katılımcıyla dayanmaktadır. 3/3 çalışma olumlu etkiler göstermektedir.

Evidence Strength72%

High confidence

Çalışma Dağılımı

RCT (3)Meta (0)Other (2)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Uykusuzluk

Daha Fazla Bilgi

References

[1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
[2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
[3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
[4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
[6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
[7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed

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