Casca de magnólia para Insônia

B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.

Baseado em 3 estudos (1 RCT) com 723 participantes no total. 3/3 estudos mostram efeitos positivos.

𝕏 LinkedIn

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Conclusão

Magnolia bark shows promising early signs for supporting sleep in people with insomnia, though most evidence comes from combination supplements rather than standalone use.

All 3 studies (including 2 RCTs) report positive effects on insomnia
723 total participants across the available research
Most studies used magnolia bark combined with other ingredients
Research has focused mainly on menopausal women

Key Study Findings

In Vitro

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a …

Dose: None vs: None Outcome: GABAA receptor modulator identification Efeito: None None

População: Zebrafish larvae and Xenopus oocytes (in vitro)

randomized_controlled_trial n=634 12 weeks

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with …

Dose: ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t vs: Placebo Efeito: ES significantly more active on insomnia, irritability, anxiety, depressed mood, asthenia, loss of l not_reported

Randomized Controlled Trial n=40 6 weeks

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a …

Dose: 250mg x 3 daily vs: Identical placebo Outcome: Effect of a proprietary Magnolia and Phellodendron extract … Efeito: None None

População: This randomized, parallel, placebo controlled clinical study was conducted with

randomized controlled trial n=89 24 weeks Open-label

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.

Dose: 1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma vs: Placebo Efeito: Significantly reduced severity/frequency of all symptoms vs Ca+D; wellbeing good/very good 66.7% vs None

Key Statistics

Estudos

763

Participantes

↑

Positive

Nota

Referenced Papers

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. Other

Molecular pharmaceutics 2019 10 citações

HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Other

Journal of natural … 2017 27 citações

Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Other

Frontiers in pharmacology 2016 15 citações

Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … RCT

Minerva ginecologica 2011 19 citações

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 citações

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. RCT

Nutrition journal 2008 51 citações

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:: 200-400 mg standardized to 90% honokiol+magnolol

Limite superior: Not established

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Mixed	--
ES: magnolia bark extract + isoflavones 60 mg + Lactobacillus sporogenes + calcium + vitamin D3 (1 t	12 weeks	Positive	634
250mg x 3 daily	6 weeks	Negative	40
1 tablet/day: soy isoflavones 60mg + lactobacilli 500M spores + calcium 141mg + vitamin D3 5mcg + Ma	24 weeks	Positive	89

Melhor horário: 30-60 minutes before bed

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Drowsiness
⚠ Dizziness
⚠ Headache
⚠ Heartburn

Interações Conhecidas

● Sedatives and alcohol — additive CNS depression
● Blood thinners — magnolol may have antiplatelet activity
● Antidiabetic drugs — may affect blood glucose levels

Ingestão máxima tolerável: Not established

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Casca de magnólia help with Insônia?

Based on 5 studies with 763 participants, there is moderate evidence from clinical studies that Casca de magnólia may support Insônia management. Our evidence grade is B (Good Evidence).

How much Casca de magnólia should I take for Insônia?

Studies have used various dosages. A commonly studied range is 200-400 mg standardized to 90% honokiol+magnolol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Casca de magnólia?

Reported side effects may include Drowsiness, Dizziness, Headache, Heartburn. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Casca de magnólia and Insônia?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 763 total participants. The overall direction of effect is positive.

Outros ingredientes para Insônia

Melatonina A Raiz de valeriana A CBD A Ácidos graxos ômega-3 A Triptófano A Vitamina D A

Casca de magnólia para outras condições

Problemas de Sono Relacionados à Ansiedade C

Veredito Rápido

Baseado em 3 estudos (1 RCT) com 723 participantes no total. 3/3 estudos mostram efeitos positivos.

Evidence Strength72%

High confidence

Detalhamento dos Estudos

RCT (3)Meta (0)Other (2)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Insônia

Saiba Mais

References

[1] Yang Yang et al.. Mol Pharm. 2019. Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep. doi:10.1021/acs.molpharmaceut.8b01016 PubMed
[2] Fahimeh Moradi-Afrapoli et al.. J Nat Prod. 2017. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. doi:10.1021/acs.jnatprod.7b00081 PubMed
[3] Katrin M Hoffmann et al.. Front Pharmacol. 2016. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. doi:10.3389/fphar.2016.00219 PubMed
[4] C Agosta et al.. Minerva Ginecol. 2011. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in … PubMed
[5] Benjamin S Weeks. Med Sci Monit. 2009. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed
[6] Douglas S Kalman et al.. Nutr J. 2008. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. doi:10.1186/1475-2891-7-11 PubMed
[7] M Mucci et al.. Minerva Ginecol. 2006. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.