Hoa Cúc cho Mất Ngủ
A Bằng chứng Nhiều thử nghiệm lâm sàng lớn liên tục cho thấy những lợi ích đáng kể.Dựa trên 27 nghiên cứu (5 meta-analyses, 4 RCTs) với 3,612 người tham gia. 17/27 nghiên cứu cho thấy tác động tích cực.
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A
Kết luận
Chamomile is well-supported by research as a gentle, natural option that may help improve sleep quality for people with insomnia.
- 17 out of 27 studies show positive effects, with Grade A evidence rating
- Both oral chamomile supplements and chamomile aromatherapy have shown benefits
- The active compound apigenin works through GABA receptors to promote sleepiness
- Benefits have been demonstrated across diverse populations including elderly and cancer patients
Key Study Findings
review
Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on …
Dose: various medicinal plant oils (topical application)
so với: Placebo
Hiệu quả: None
None
randomized_controlled_trial
n=80
2 weeks
Effects of chamomile oil inhalation on sleep quality in young adults with insomnia: A randomized …
Dose: chamomile oil inhalation for 10 minutes per day for 15 days
so với: Placebo
Hiệu quả: significant reduction in PSQI and ISI in aromatherapy group vs control (p<0.001 for both between-gro
<0.001 (between-group PSQI and
basic science
German Chamomile (Matricaria chamomilla) Induces Cytochrome P450 Expression Through Increased BMAL1 Protein Expression in Liver …
Dose: German chamomile (Matricaria chamomilla) extract
so với: Placebo
Hiệu quả: None
None
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
so với: Placebo
Hiệu quả: None
None
Review
A review on essential oils: A potential tonic for mental wellbeing in the aging population?
Dose: None
so với: Placebo
Hiệu quả: None
None
narrative review
Herbal and Natural Supplements for Improving Sleep: A Literature Review.
Dose: varies by supplement
so với: Placebo
Hiệu quả: None
None
Key Statistics
27
Nghiên cứu
3612
Người tham gia
↑
Positive
A
Xếp hạng
Referenced Papers
International journal of …
2025
6 trích dẫn
Naunyn-Schmiedeberg's archives of …
2025
4 trích dẫn
Maturitas
2025
4 trích dẫn
Avicenna journal of …
2025
Biochemical genetics
2025
Psychiatry investigation
2024
24 trích dẫn
Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials.
Meta-Analysis
Complementary therapies in …
2024
23 trích dẫn
Frontiers in public …
2023
13 trích dẫn
Biomolecules & therapeutics
2023
7 trích dẫn
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Meta-Analysis
Pharmacological research
2022
51 trích dẫn
Frontiers in pharmacology
2022
31 trích dẫn
Combinatorial chemistry & …
2021
16 trích dẫn
Advances in experimental …
2021
7 trích dẫn
Phytotherapy research : …
2019
62 trích dẫn
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 trích dẫn
Complementary therapies in …
2017
65 trích dẫn
The Effect of Aromatherapy on Insomnia and Other Common Symptoms Among Patients With Acute Leukemia.
Other
Oncology nursing forum
2017
58 trích dẫn
Sleep medicine reviews
2015
152 trích dẫn
The Australian and …
2014
32 trích dẫn
BMC complementary and …
2011
112 trích dẫn
Molecular medicine reports
2010
398 trích dẫn
Sleep medicine
2009
54 trích dẫn
Journal of psychopharmacology …
2005
176 trích dẫn
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 trích dẫn
Primary care
2002
43 trích dẫn
The Journal of …
2000
5 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- sleep:
- 270-400 mg extract or 1-3 cups tea
Giới hạn trên: Not established
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| various medicinal plant oils (topical application) | -- | Positive | -- |
| chamomile oil inhalation for 10 minutes per day for 15 days | 2 weeks | Positive | 80 |
| German chamomile (Matricaria chamomilla) extract | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| varies by supplement | -- | Positive | -- |
| varies | -- | Positive | 772 |
| single essential oil or blended oil massage; specific volumes not reported in abstract | -- | Positive | -- |
Thời điểm dùng tốt nhất: 30-60 minutes before bed
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Allergic reactions (ragweed family)
- ⚠ Nausea
- ⚠ Drowsiness
Tương tác đã biết
- ● Blood thinners (warfarin) — chamomile contains coumarin compounds
- ● CYP1A2 substrates — chamomile may inhibit this enzyme
- ● Sedatives — mild additive effects
Mức hấp thụ tối đa cho phép: Not established
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Hoa Cúc help with Mất Ngủ?
Based on 27 studies with 3,612 participants, there is strong evidence from multiple clinical trials that Hoa Cúc may support Mất Ngủ management. Our evidence grade is A (Strong Evidence).
How much Hoa Cúc should I take for Mất Ngủ?
Studies have used various dosages. A commonly studied range is 270-400 mg extract or 1-3 cups tea. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Hoa Cúc?
Reported side effects may include Allergic reactions (ragweed family), Nausea, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Hoa Cúc and Mất Ngủ?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 27 peer-reviewed studies with 3,612 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Mất Ngủ
Hoa Cúc cho các tình trạng khác
References
- [1] Y Deepa et al.. Int J Psychiatry Med. 2025. Effects of chamomile oil inhalation on sleep quality in young adults with insomnia: A randomized controlled trial. doi:10.1177/00912174241301279 PubMed
- [2] Yasmina M Ebrahim et al.. Naunyn Schmiedebergs Arch Pharmacol. 2025. Integrative sleep management: from molecular pathways to conventional and herbal treatments. doi:10.1007/s00210-025-04183-y PubMed
- [3] Vivek Chavda et al.. Maturitas. 2025. A review on essential oils: A potential tonic for mental wellbeing in the aging population? doi:10.1016/j.maturitas.2024.108158 PubMed
- [4] Maryam Mohammadian-Dameski et al.. Avicenna J Phytomed. 2025. Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine. doi:10.22038/AJP.2024.24303 PubMed
- [5] Moka Ikeda et al.. Biochem Genet. 2025. German Chamomile (Matricaria chamomilla) Induces Cytochrome P450 Expression Through Increased BMAL1 Protein Expression in Liver Nuclei. doi:10.1007/s10528-025-11260-7 PubMed
- [6] Ji Won Yeom et al.. Psychiatry Investig. 2024. Herbal and Natural Supplements for Improving Sleep: A Literature Review. doi:10.30773/pi.2024.0121 PubMed
- [7] Asma Kazemi et al.. Complement Ther Med. 2024. Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials. doi:10.1016/j.ctim.2024.103071 PubMed
- [8] Fei-Yi Zhao et al.. Front Public Health. 2023. Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and critical assessment of comprehensive clinical … doi:10.3389/fpubh.2023.1157419 PubMed
- [9] Kyung-Bok Lee et al.. Biomol Ther (Seoul). 2023. Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment. doi:10.4062/biomolther.2023.014 PubMed
- [10] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
- [11] Sin Yee Lee et al.. Front Pharmacol. 2022. Effect of drying methods on yield, physicochemical properties, and total polyphenol content of chamomile extract powder. doi:10.3389/fphar.2022.1003209 PubMed
- [12] Ruhi Ali et al.. Comb Chem High Throughput Screen. 2021. Nutraceuticals for Sleep Disorders. doi:10.2174/1386207324666210121111446 PubMed
- [13] Diana Lelli et al.. Adv Exp Med Biol. 2021. Use of Plant-Derived Natural Products in Sleep Disturbances. doi:10.1007/978-3-030-64872-5_15 PubMed
- [14] Truong Hong Hieu et al.. Phytother Res. 2019. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and … doi:10.1002/ptr.6349 PubMed
- [15] Karen Savage et al.. Phytother Res. 2018. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. doi:10.1002/ptr.5940 PubMed
- [16] Mohsen Adib-Hajbaghery et al.. Complement Ther Med. 2017. The effects of chamomile extract on sleep quality among elderly people: A clinical trial. doi:10.1016/j.ctim.2017.09.010 PubMed
- [17] Lisa Blackburn et al.. Oncol Nurs Forum. 2017. The Effect of Aromatherapy on Insomnia and Other Common Symptoms Among Patients With Acute Leukemia. doi:10.1188/17.ONF.E185-E193 PubMed
- [18] Matthew J Leach et al.. Sleep Med Rev. 2015. Herbal medicine for insomnia: A systematic review and meta-analysis. doi:10.1016/j.smrv.2014.12.003 PubMed
- [19] Ji Hyun Baek et al.. Aust N Z J Psychiatry. 2014. Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. doi:10.1177/0004867414539198 PubMed
- [20] Suzanna M Zick et al.. BMC Complement Altern Med. 2011. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot … doi:10.1186/1472-6882-11-78 PubMed
- [21] Janmejai K Srivastava et al.. Mol Med Rep. 2010. Chamomile: A herbal medicine of the past with bright future. doi:10.3892/mmr.2010.377 PubMed
- [22] M Montserrat Sánchez-Ortuño et al.. Sleep Med. 2009. The use of natural products for sleep: A common practice? doi:10.1016/j.sleep.2008.10.009 PubMed
- [23] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
- [24] Amy Lynn Meolie et al.. J Clin Sleep Med. 2005. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. PubMed
- [25] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed
- [26] Michele M Larzelere et al.. Prim Care. 2002. Anxiety, depression, and insomnia. doi:10.1016/s0095-4543(01)00003-3 PubMed
- [27] T R Dockrell et al.. J Sch Nurs. 2000. An overview of herbal medications with implications for the school nurse. doi:10.1177/105984050001600308 PubMed
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