Iron के लिए Restless Leg Syndrome

Q: Does Iron help with Restless Leg Syndrome?

Based on 173 studies with 36,638 participants, there is strong evidence from multiple clinical trials that Iron may support Restless Leg Syndrome management. Our evidence grade is A (Strong Evidence).

Q: How much Iron should I take for Restless Leg Syndrome?

Studies have used various dosages. A commonly studied range is 65 mg elemental iron if ferritin <75. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Iron?

Reported side effects may include Constipation, Nausea, Stomach pain, Dark stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Iron and Restless Leg Syndrome?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 173 peer-reviewed studies with 36,638 total participants. The overall direction of effect is mixed.

65 अध्ययनों (5 meta-analyses) पर आधारित, में कुल 24,923 प्रतिभागियों के साथ। 34/65 अध्ययन सकारात्मक प्रभाव दिखाते हैं।

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निष्कर्ष

Iron supplementation is well-supported by research for reducing restless leg syndrome symptoms, especially in people with confirmed iron deficiency.

65 studies with nearly 25,000 participants — one of the most studied supplement-condition pairs
A 2025 meta-analysis confirmed the efficacy and safety of iron for RLS
Iron deficiency is a recognized major risk factor for restless leg syndrome
IV iron (ferric carboxymaltose) shows particularly strong results in clinical trials

Key Study Findings

review

[Restless leg syndrome. Diagnosis and treatment].

Dose: various बनाम: Placebo प्रभाव: None None

case-control n=90

Restless Leg Syndrome and Association with Serum NT Pro-CNP.

Dose: None बनाम: Placebo प्रभाव: NT pro-CNP significantly lower in RLS vs controls; sensitivity 80%, specificity 88.9%; serum iron lo None

Cohort Study n=58 Open-label

Efficacy and safety of intravenous iron in patients with restless legs syndrome with normal serum …

Dose: 1000 mg ferric carboxymaltose बनाम: Group A (ferritin <100) vs Group B (ferritin 100-300) Outcome: IRLS severity scale score change प्रभाव: None None

जनसंख्या: RLS patients with serum ferritin <300 µg/L

review

Restless Leg Syndrome and Pregnancy.

Dose: iron supplementation, folate, dopamine agonists (non-pharmacological and pharmacological) बनाम: Placebo प्रभाव: None None

review

[Restless Legs Syndrome].

Dose: dopamine agonists, iron supplementation, alpha-2-delta ligands बनाम: Placebo प्रभाव: None None

review

Optimizing Restless Legs Syndrome Care: Integrating Rehabilitation into Multimodal Management.

Dose: None बनाम: Placebo प्रभाव: None None

Key Statistics

173

अध्ययन

36638

प्रतिभागी

↔

Mixed

ग्रेड

Referenced Papers

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Restless Leg Syndrome and Association with Serum NT Pro-CNP. Other

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Restless legs syndrome. Pathophysiology, diagnosis and treatment. Review

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Efficacy and safety of intravenous iron in patients with restless legs syndrome with normal serum ferritin levels: a stratified subanalysis. Other

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Iron Metabolism and the Role of Iron Therapy in Pediatric Restless Leg Syndrome. Review

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Intersecting Pathways: Treating Cocaine Withdrawal and Restless Leg Syndrome with Iron and Buproprion. Case Report

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Restless Legs Syndrome and Restless Sleep Disorder in Children. Review

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Restless leg syndrome in patients with chronic kidney disease: a hospital-based study from Upper Egypt. Other

The International journal … 2023 14 उद्धरण

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The genetic etiology of periodic limb movement in sleep. Meta-Analysis

Sleep 2023 8 उद्धरण

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 उद्धरण

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 उद्धरण

Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: Implications on the dopaminergic system and PTPRD. Other

Sleep medicine 2023 3 उद्धरण

Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders. Review

Continuum (Minneapolis, Minn.) 2023 2 उद्धरण

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Nutrients 2023

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Neurological research 2023

The incidence, complications, and treatment of iron deficiency in pregnancy. Review

European journal of … 2022 109 उद्धरण

Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review). Review

Experimental and therapeutic … 2022 60 उद्धरण

Brain-iron deficiency models of restless legs syndrome. Review

Experimental neurology 2022 36 उद्धरण

[Therapeutic approaches for sleep and rhythms disorders in children with ASD]. RCT

L'Encephale 2022 21 उद्धरण

Exploration of restless legs syndrome under the new concept: A review. Review

Medicine 2022 15 उद्धरण

Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging. Meta-Analysis

NeuroImage. Clinical 2022 14 उद्धरण

Treating Severe Refractory and Augmented Restless Legs Syndrome. Review

Chest 2022 14 उद्धरण

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 उद्धरण

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 उद्धरण

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 उद्धरण

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Does Dexmedetomidine Improve or Worsen Restless Leg Syndrome under Sedation: A Case Report and Extensive Review. Case Report

Case reports in … 2022 3 उद्धरण

Restless Leg Syndrome in Hemodialysis Patients: A Narrative Review. Review

The neurologist 2022 3 उद्धरण

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Restless Legs Syndrome and the Eyes: Spectral-Domain Optic Coherence Tomography Study. Other

The neurologist 2022 1 उद्धरण

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Diagnostic and Treatment Considerations in Restless Legs Syndrome Complicated by Diabetic Neuropathy. Review

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Cureus 2020 5 उद्धरण

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Der Nervenarzt 2020 2 उद्धरण

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New Insights into the Neurobiology of Restless Legs Syndrome. Review

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Update on Restless Legs Syndrome: from Mechanisms to Treatment. Review

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Sleep medicine reviews 2019 47 उद्धरण

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Restless legs syndrome and iron deficiency in adults with attention-deficit/hyperactivity disorder. Other

Sleep 2019 33 उद्धरण

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Drug Treatment of Restless Legs Syndrome in Older Adults. Review

Drugs & aging 2019 14 उद्धरण

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

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Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an … Other

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Brain imaging and networks in restless legs syndrome. Review

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Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome. Review

Journal of neurology 2017 94 उद्धरण

Central and peripheral nervous system excitability in restless legs syndrome. Review

Sleep medicine 2017 92 उद्धरण

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Practical neurology 2017 69 उद्धरण

Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters. Other

Scientific reports 2017 66 उद्धरण

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

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A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 उद्धरण

Bupropion and Iron for Restless Leg Syndrome: Do They Have Efficacy Similar to Ropinirole? Other

Annals of Indian … 2017 1 उद्धरण

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force … Other

Sleep medicine 2016 280 उद्धरण

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Neurology 2016 210 उद्धरण

Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Review

Acta neurologica Scandinavica 2016 104 उद्धरण

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Clinical medicine (London, … 2016 44 उद्धरण

Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital. Other

Nephro-urology monthly 2016 21 उद्धरण

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 उद्धरण

Importance of donor history of restless leg syndrome and pica to asses iron deficiency. Other

Transfusion and apheresis … 2016 10 उद्धरण

Restless Leg Syndrome/Willis-Ekbom disease in women with iron deficiency anemia. Other

Ideggyogyaszati szemle 2016 6 उद्धरण

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 उद्धरण

Predictive factors of restless leg syndrome in hemodialysis patients. Other

Journal of renal … 2016 2 उद्धरण

[Iron deficiency, Fatigue and Restless-Legs-Syndrome]. Review

Wiener medizinische Wochenschrift … 2016 2 उद्धरण

Asthma as a disruption in iron homeostasis. Review

Biometals : an … 2016

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Review

Sleep medicine clinics 2015 158 उद्धरण

Restless legs syndrome: clinical presentation diagnosis and treatment. Review

Sleep medicine 2015 72 उद्धरण

Restless legs syndrome in multiple sclerosis. Review

Sleep medicine reviews 2015 38 उद्धरण

Restless Legs Syndrome/Willis-Ekbom Disease and Growing Pains in Children and Adolescents. Review

Sleep medicine clinics 2015 29 उद्धरण

Neuroimaging in Restless Legs Syndrome. Review

Sleep medicine clinics 2015 29 उद्धरण

Restless legs syndrome. Review

Critical care clinics 2015 28 उद्धरण

Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities. Review

Sleep medicine clinics 2015 28 उद्धरण

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 उद्धरण

[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)]. Review

Nihon rinsho. Japanese … 2015

[RESTLESS LEGS SYNDROME--WILLIS-EKBOM DISEASE]. Other

La Revue du … 2015

Therapeutic advances in restless legs syndrome (RLS). Meta-Analysis

Movement disorders : … 2015

Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease). Review

Sleep medicine 2014 281 उद्धरण

Restless legs syndrome and pregnancy: a review. Review

Parkinsonism & related … 2014 78 उद्धरण

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease). Other

Sleep medicine 2014 58 उद्धरण

Disorders of heavy metals. Review

Handbook of clinical … 2014 52 उद्धरण

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 उद्धरण

The association of Restless Legs Syndrome with hypertension and cardiovascular disease. Review

Medical science monitor … 2014 18 उद्धरण

Latest guidelines and advances for treatment of restless legs syndrome. Review

The Journal of … 2014 12 उद्धरण

New treatment options for the management of restless leg syndrome. Review

The Journal of … 2014 7 उद्धरण

Treatment of pediatric restless legs syndrome. Other

Clinical pediatrics 2014

Restless legs syndrome, pica, and iron status in blood donors. Other

Transfusion 2013 64 उद्धरण

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 उद्धरण

Migraine and restless leg syndrome co-morbidity may be due to iron deficiency. Other

Annals of Indian … 2013 6 उद्धरण

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 उद्धरण

Iron for restless legs syndrome. Meta-Analysis

The Cochrane database … 2012 31 उद्धरण

ADMET considerations for restless leg syndrome drug treatments. Review

Expert opinion on … 2012 6 उद्धरण

Nocturnal leg cramps. Review

American family physician 2012

Iron deficiency: beyond anemia. Review

Indian journal of … 2011 75 उद्धरण

Restless legs syndrome. Review

Handbook of clinical … 2011 8 उद्धरण

Restless legs syndrome: pathophysiology, clinical presentation and management. Review

Nature reviews. Neurology 2010 293 उद्धरण

Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment. Review

Sleep medicine 2010 115 उद्धरण

Finding a safe and effective intravenous iron treatment for restless legs syndrome. Other

Sleep medicine 2010

Update in restless legs syndrome. Review

Current opinion in … 2010

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis. Review

Clinics (Sao Paulo, … 2010

Restless legs syndrome. Review

Journal of internal … 2009 125 उद्धरण

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 उद्धरण

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 उद्धरण

Restless legs syndrome: differential diagnosis and management with pramipexole. Review

Clinical interventions in … 2009

[Secondary restless legs syndrome]. Review

Brain and nerve … 2009

Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Review

Sleep 2009

Diagnosis and management of restless legs syndrome in children. Review

Sleep medicine reviews 2009

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 उद्धरण

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 उद्धरण

[Restless legs syndrome]. Review

Acta medica portuguesa 2008

Restless legs syndrome. Other

American family physician 2008

Restless legs syndrome: pathophysiology, diagnosis and treatment. Review

CNS drugs 2008

Pathophysiology of restless legs syndrome: evidence for iron involvement. Review

Current neurology and … 2008

An update on the pathophysiology and genetics of restless legs syndrome. Review

Current neurology and … 2008

Restless leg syndrome: iron important. Case Report

The Nurse practitioner 2008

Nonhematological benefits of iron. Review

American journal of … 2007 61 उद्धरण

Update of the pathophysiology of the restless-legs-syndrome. Review

Movement disorders : … 2007

Animal models of restless legs syndrome. Review

Sleep medicine 2007

Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome. Review

The American journal … 2007

Restless legs syndrome: demographics, presentation, and differential diagnosis. Review

Geriatrics 2007

Is iron deficiency an underlying cause of pediatric restless legs syndrome and of attention-deficit/hyperactivity disorder? Other

Sleep medicine 2007

Restless legs syndrome: pathophysiology and the role of iron and folate. Review

Alternative medicine review … 2007

Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. Other

Sleep medicine 2007

Epithelial regeneration from bioengineered skin explants in culture. Other

The British journal … 2006 29 उद्धरण

Restless legs syndrome. Review

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Iron and restless legs syndrome: the story unfolds. Other

Sleep medicine 2006 8 उद्धरण

Is restless legs syndrome underrecognized? Current management. Review

Joint bone spine 2006

The restless legs syndrome. Review

The Lancet. Neurology 2005 215 उद्धरण

The restless legs syndrome. Review

Progress in neurobiology 2005 47 उद्धरण

Restless legs syndrome. Review

Current neurology and … 2005 15 उद्धरण

Restless legs syndrome. Review

Neurologic clinics 2005 13 उद्धरण

Role of medications in the etiology and treatment of restless leg syndrome. Other

Home healthcare nurse 2005 3 उद्धरण

Restless legs syndrome. Review

Primary care 2005 2 उद्धरण

Restless legs syndrome. Review

Current opinion in … 2005

Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Review

Sleep medicine 2004 392 उद्धरण

Restless legs syndrome and pregnancy. Other

Neurology 2004 386 उद्धरण

Childhood-onset restless legs syndrome. Other

Annals of neurology 2004 183 उद्धरण

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 उद्धरण

Epidemiology and clinical findings of restless legs syndrome. Review

Sleep medicine 2004

P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

American journal of … 2004

Restless legs syndrome and PD: a review of the evidence for a possible association. Review

Neurology 2003

Treating restless legs syndrome: current pathophysiological concepts and clinical trials. Review

Expert opinion on … 2002

Restless legs syndrome in the older adult: diagnosis and management. Review

Drugs & aging 2002

The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

Medical hypotheses 2002

Iron, brain and restless legs syndrome. Other

Sleep medicine reviews 2001 48 उद्धरण

Restless legs syndrome. Review

The Journal of … 2001 7 उद्धरण

Restless legs syndrome: a review of clinical and pathophysiologic features. Review

Journal of clinical … 2001

Insight into the pathophysiology of restless legs syndrome. Review

Journal of neuroscience … 2000

Secondary periodic limb movement disorder and restless legs syndrome. Other

Sleep medicine reviews 1999 31 उद्धरण

How to help patients with restless legs syndrome. Discerning the indescribable and relaxing the restless. Review

Postgraduate medicine 1999

Iron and the restless legs syndrome. Other

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Restless legs syndrome. Review

Mayo Clinic proceedings 1997 30 उद्धरण

Carcinosarcoma of the skin. Case report and literature review. Case Report

The American Journal … 1996 1 उद्धरण

Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

rls:: 65 mg elemental iron if ferritin <75
general:: 18 mg/day (women)

अधिकतम सीमा: 45 mg/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
various	--	Positive	--
None	--	Positive	90
1000 mg ferric carboxymaltose	--	Positive	58
iron supplementation, folate, dopamine agonists (non-pharmacological and pharmacological)	--	Positive	--
dopamine agonists, iron supplementation, alpha-2-delta ligands	--	Positive	--
None	--	Neutral	--
None	--	Mixed	--
None	--	Positive	--

सेवन का सर्वोत्तम समय: On an empty stomach with vitamin C; take in the morning, not before bed

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Constipation
⚠ Nausea
⚠ Stomach pain
⚠ Dark stools
⚠ Iron overload risk (hemochromatosis)

ज्ञात अंतःक्रियाएँ

● Antacids and PPIs — reduce iron absorption
● Levothyroxine — iron reduces thyroid medication absorption
● Antibiotics (tetracyclines, fluoroquinolones) — mutual absorption reduction
● Calcium supplements — take separately by 2 hours

सहनीय अधिकतम सेवन: 45 mg/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Iron help with Restless Leg Syndrome?

Based on 173 studies with 36,638 participants, there is strong evidence from multiple clinical trials that Iron may support Restless Leg Syndrome management. Our evidence grade is A (Strong Evidence).

How much Iron should I take for Restless Leg Syndrome?

Studies have used various dosages. A commonly studied range is 65 mg elemental iron if ferritin <75. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Iron?

Reported side effects may include Constipation, Nausea, Stomach pain, Dark stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Iron and Restless Leg Syndrome?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 173 peer-reviewed studies with 36,638 total participants. The overall direction of effect is mixed.

Related Evidence

इसके लिए अन्य सामग्री Restless Leg Syndrome

Magnesium Glycinate F

संक्षिप्त निष्कर्ष

Evidence Strength92%

High confidence

अध्ययन विश्लेषण

RCT (3)Meta (9)Other (161)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Restless Leg Syndrome

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।