Restless Legs Syndrome: Neurochemistry and Therapy.

David Anguizola, Alba Garcia Aragón, Brian Moncada, Diego Garcia-Borreguero

Review Seminars in neurology 2025

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अध्ययन प्रकार: Review
जनसंख्या: Patients with restless legs syndrome

हस्तक्षेप: Restless Legs Syndrome: Neurochemistry and Therapy. None
तुलनित्र: None
प्राथमिक परिणाम: None
प्रभाव की दिशा: Mixed
पूर्वाग्रह का जोखिम: Unclear

Abstract

Restless legs syndrome (RLS) is a complex sensorimotor disorder characterized by disturbances in key neurochemical pathways, including dopaminergic, glutamatergic, and adenosinergic systems. This review provides an overview of the current knowledge on RLS, including its clinical features and diagnosis, pathophysiology, and treatment (non-pharmacological and pharmacological). We examine the association between RLS and neurological disorders, genetic predispositions, and brain iron deficiency. Emerging therapies targeting glutamate and adenosine receptors, alongside established dopamine agonists and α2δ ligands, offer promising avenues for treatment.

Used In Evidence Reviews

A Iron के लिए Restless Leg Syndrome

Restless Legs Syndrome: Neurochemistry and Therapy.

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