Magnesium Glycinate के लिए Restless Leg Syndrome

25 अध्ययनों (3 meta-analyses, 1 RCT) पर आधारित, में कुल 31,304 प्रतिभागियों के साथ। 15/25 अध्ययन सकारात्मक प्रभाव दिखाते हैं।

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निष्कर्ष

Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.

15 out of 25 studies show positive effects with 31,304 participants across all study types
A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
Low magnesium levels are consistently associated with higher RLS risk
Particularly relevant for pregnant women and kidney disease patients with RLS

Key Study Findings

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None बनाम: None Outcome: Causal association of micronutrients with RLS प्रभाव: Retinol OR 0.46; Mg OR 0.62 None

जनसंख्या: European ancestry (7248 RLS cases, 19802 controls)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None बनाम: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention प्रभाव: None None

जनसंख्या: Obese C57 mice with DSS-induced UC

Randomized Controlled Trial

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …

Dose: BCM or ADM seeded with PRP-grown fibroblasts बनाम: Free gingival grafts (FGG) Outcome: Wound healing of mucogingival defects प्रभाव: None None

जनसंख्या: Animal model (mucogingival defects)

Systematic Review

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.

Dose: None बनाम: None Outcome: Sleep quality प्रभाव: None None

जनसंख्या: None

In Vitro

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.

Dose: B. amylolyquefaciens B65 lipopeptides बनाम: None Outcome: Surfactant and antibacterial properties प्रभाव: None None

जनसंख्या: In vitro industrial microbiology study

Other n=10 8 weeks Open-label

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …

Dose: 200 mg बनाम: Placebo Outcome: Quality of life प्रभाव: None P = .006

जनसंख्या: None

Key Statistics

अध्ययन

8833

प्रतिभागी

↔

Mixed

ग्रेड

Referenced Papers

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 उद्धरण

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. Other

Journal of clinical … 2024 6 उद्धरण

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 उद्धरण

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. Other

World journal of … 2024 2 उद्धरण

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … Other

Journal of periodontal … 2024

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 उद्धरण

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … RCT

Redox biology 2023 5 उद्धरण

Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. Other

Animal bioscience 2023 3 उद्धरण

A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

Neurological research 2023

Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

Nutrients 2023

Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. Other

Frontiers in microbiology 2022 27 उद्धरण

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. RCT

BMC complementary medicine … 2022 16 उद्धरण

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 उद्धरण

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 उद्धरण

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 उद्धरण

Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. Other

Biological trace element … 2021 17 उद्धरण

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. Other

Nutrients 2021 11 उद्धरण

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 उद्धरण

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

Reumatismo 2020 21 उद्धरण

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 उद्धरण

Iodine and folate-essential for mothers to be. Other

The lancet. Diabetes … 2020 2 उद्धरण

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. Other

Sleep 2019 38 उद्धरण

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. Systematic Review

Sleep medicine reviews 2019 23 उद्धरण

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Other

Nutrients 2019 23 उद्धरण

Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in … Observational

BMJ open 2019 7 उद्धरण

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … RCT

Journal of medicinal … 2018 37 उद्धरण

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. Other

Experimental eye research 2018 33 उद्धरण

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands. Other

PloS one 2018 11 उद्धरण

Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. Other

Journal of cellular … 2017 12 उद्धरण

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 उद्धरण

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 उद्धरण

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 उद्धरण

Magnesium deficiency: a possible cause of restless leg syndrome in haemodialysis patients. Other

Internal medicine journal 2015 5 उद्धरण

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 उद्धरण

[Differential diagnosis and treatment of cramps]. Review

MMW Fortschritte der … 2013 3 उद्धरण

Nocturnal leg cramps. Review

American family physician 2012

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 उद्धरण

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 उद्धरण

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 उद्धरण

Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Other

Skin research and … 2008 67 उद्धरण

Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studies. Other

Sleep medicine 2007 18 उद्धरण

Sources of folate and serum folate levels in older adults. Other

Journal of the … 2007 10 उद्धरण

Epithelial regeneration from bioengineered skin explants in culture. Other

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Intravenous magnesium sulfate may relieve restless legs syndrome in pregnancy. Case Report

Journal of clinical … 2006

Role of medications in the etiology and treatment of restless leg syndrome. Other

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P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

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Ketamine for restless legs syndrome. Other

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The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

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Secondary periodic limb movement disorder and restless legs syndrome. Other

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Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Other

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Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 200-400 mg elemental Mg, before bed

अधिकतम सीमा: 350 mg/day (supplemental Mg)

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Mixed	--
None	--	Positive	--
BCM or ADM seeded with PRP-grown fibroblasts	--	Positive	--
None	--	Positive	--
B. amylolyquefaciens B65 lipopeptides	--	Neutral	--
200 mg	8 weeks	Mixed	10
5 g	--	Positive	--
None	--	Mixed	--

सेवन का सर्वोत्तम समय: 30-60 minutes before bed

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Loose stools or diarrhea
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure at high doses

ज्ञात अंतःक्रियाएँ

● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
● Bisphosphonates — magnesium may decrease efficacy
● Blood pressure medications — additive hypotensive effects

सहनीय अधिकतम सेवन: 350 mg/day (supplemental Mg)

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Magnesium Glycinate help with Restless Leg Syndrome?

Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that Magnesium Glycinate may support Restless Leg Syndrome management. Our evidence grade is F (Evidence Against).

How much Magnesium Glycinate should I take for Restless Leg Syndrome?

Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Magnesium Glycinate?

Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Magnesium Glycinate and Restless Leg Syndrome?

We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.

Related Evidence

इसके लिए अन्य सामग्री Restless Leg Syndrome

Iron A

Magnesium Glycinate अन्य स्वास्थ्य स्थितियों के लिए

नींद शुरू होने में कठिनाई A अनिद्रा A चिंता-संबंधी नींद की समस्याएं B

संक्षिप्त निष्कर्ष

Evidence Strength10%

Low confidence

अध्ययन विश्लेषण

RCT (4)Meta (0)Other (50)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Restless Leg Syndrome

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।