甘氨酸镁用于不宁腿综合征

基于25项研究（3项荟萃分析、1项RCT），共31,304名参与者。15/25项研究显示积极效果。

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结论

Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.

15 out of 25 studies show positive effects with 31,304 participants across all study types
A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
Low magnesium levels are consistently associated with higher RLS risk
Particularly relevant for pregnant women and kidney disease patients with RLS

Key Study Findings

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None vs: None Outcome: Causal association of micronutrients with RLS 效果: Retinol OR 0.46; Mg OR 0.62 None

研究人群: European ancestry (7248 RLS cases, 19802 controls)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None vs: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention 效果: None None

研究人群: Obese C57 mice with DSS-induced UC

Randomized Controlled Trial

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …

Dose: BCM or ADM seeded with PRP-grown fibroblasts vs: Free gingival grafts (FGG) Outcome: Wound healing of mucogingival defects 效果: None None

研究人群: Animal model (mucogingival defects)

Systematic Review

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.

Dose: None vs: None Outcome: Sleep quality 效果: None None

研究人群: None

In Vitro

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.

Dose: B. amylolyquefaciens B65 lipopeptides vs: None Outcome: Surfactant and antibacterial properties 效果: None None

研究人群: In vitro industrial microbiology study

Other n=10 8 weeks Open-label

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …

Dose: 200 mg vs: Placebo Outcome: Quality of life 效果: None P = .006

研究人群: None

Key Statistics

研究数量

8833

受试者

↔

Mixed

等级

Referenced Papers

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 次引用

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. Other

Journal of clinical … 2024 6 次引用

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 次引用

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. Other

World journal of … 2024 2 次引用

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … Other

Journal of periodontal … 2024

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 次引用

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … RCT

Redox biology 2023 5 次引用

Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. Other

Animal bioscience 2023 3 次引用

A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

Neurological research 2023

Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

Nutrients 2023

Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. Other

Frontiers in microbiology 2022 27 次引用

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. RCT

BMC complementary medicine … 2022 16 次引用

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 次引用

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 次引用

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 次引用

Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. Other

Biological trace element … 2021 17 次引用

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. Other

Nutrients 2021 11 次引用

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 次引用

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

Reumatismo 2020 21 次引用

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 次引用

Iodine and folate-essential for mothers to be. Other

The lancet. Diabetes … 2020 2 次引用

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. Other

Sleep 2019 38 次引用

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. Systematic Review

Sleep medicine reviews 2019 23 次引用

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Other

Nutrients 2019 23 次引用

Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in … Observational

BMJ open 2019 7 次引用

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … RCT

Journal of medicinal … 2018 37 次引用

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. Other

Experimental eye research 2018 33 次引用

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands. Other

PloS one 2018 11 次引用

Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. Other

Journal of cellular … 2017 12 次引用

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 次引用

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 次引用

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 次引用

Magnesium deficiency: a possible cause of restless leg syndrome in haemodialysis patients. Other

Internal medicine journal 2015 5 次引用

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 次引用

[Differential diagnosis and treatment of cramps]. Review

MMW Fortschritte der … 2013 3 次引用

Nocturnal leg cramps. Review

American family physician 2012

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 次引用

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 次引用

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 次引用

Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Other

Skin research and … 2008 67 次引用

Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studies. Other

Sleep medicine 2007 18 次引用

Sources of folate and serum folate levels in older adults. Other

Journal of the … 2007 10 次引用

Epithelial regeneration from bioengineered skin explants in culture. Other

The British journal … 2006 29 次引用

Intravenous magnesium sulfate may relieve restless legs syndrome in pregnancy. Case Report

Journal of clinical … 2006

Role of medications in the etiology and treatment of restless leg syndrome. Other

Home healthcare nurse 2005 3 次引用

Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--. Other

Neurophysiologie clinique = … 2004 31 次引用

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 次引用

P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

American journal of … 2004

Ketamine for restless legs syndrome. Other

Anesthesia and analgesia 2003 1 次引用

The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

Medical hypotheses 2002

Phosphatidylethanolamine deficiency in membrane lipids inhibits keratinocyte intercellular networks formation. Other

In vitro cellular … 2001 14 次引用

Secondary periodic limb movement disorder and restless legs syndrome. Other

Sleep medicine reviews 1999 31 次引用

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Other

Sleep 1998 108 次引用

Characterization of epithelial primary cultures from human conjunctiva. Other

Graefe's archive for … 1997 33 次引用

Carcinosarcoma of the skin. Case report and literature review. Case Report

The American Journal … 1996 1 次引用

Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Other

Electrophoresis 1995 57 次引用

Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Other

Romanian journal of … 1993 25 次引用

The establishment and continuous subculturing of normal human adult hepatocytes: expression of differentiated liver functions. Other

Cell biology and … 1993 10 次引用

Clonal growth of epithelial cells from normal adult human bronchus. Other

Cancer research 1981 204 次引用

Restless legs syndrome. Sleep-electroencephalographic and neurologic findings. Other

JAMA 1974 21 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 200-400 mg elemental Mg, before bed

上限： 350 mg/day (supplemental Mg)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Positive	--
BCM or ADM seeded with PRP-grown fibroblasts	--	Positive	--
None	--	Positive	--
B. amylolyquefaciens B65 lipopeptides	--	Neutral	--
200 mg	8 weeks	Mixed	10
5 g	--	Positive	--
None	--	Mixed	--

最佳服用时间： 30-60 minutes before bed

Safety & Side Effects

已报告的副作用

⚠ Loose stools or diarrhea
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure at high doses

已知相互作用

● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
● Bisphosphonates — magnesium may decrease efficacy
● Blood pressure medications — additive hypotensive effects

可耐受最高摄入量： 350 mg/day (supplemental Mg)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 甘氨酸镁 help with 不宁腿综合征?

Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that 甘氨酸镁 may support 不宁腿综合征 management. Our evidence grade is F (Evidence Against).

How much 甘氨酸镁 should I take for 不宁腿综合征?

Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 甘氨酸镁?

Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 甘氨酸镁 and 不宁腿综合征?

We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.

Related Evidence

其他成分用于不宁腿综合征

铁 A

甘氨酸镁用于其他健康状况

入睡困难 A 失眠 A 焦虑相关性睡眠问题 B

快速结论

基于25项研究（3项荟萃分析、1项RCT），共31,304名参与者。15/25项研究显示积极效果。

Evidence Strength10%

Low confidence

研究分析

RCT (4)Meta (0)Other (50)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于不宁腿综合征

了解更多

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