グリシン酸マグネシウム：むずむず脚症候群

合計31,304名の参加者を対象とした25件の研究（メタアナリシス3件、RCT 1件を含む）に基づく。25件中15件の研究で肯定的な効果が示されている。

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'sleepcited.com'; const params = 'ingredient\u003Dmagnesium\u002Dglycinate\u0026condition\u003Drestless\u002Dleg\u002Dsyndrome'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

結論

Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.

15 out of 25 studies show positive effects with 31,304 participants across all study types
A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
Low magnesium levels are consistently associated with higher RLS risk
Particularly relevant for pregnant women and kidney disease patients with RLS

Key Study Findings

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None vs: None Outcome: Causal association of micronutrients with RLS 効果: Retinol OR 0.46; Mg OR 0.62 None

対象集団: European ancestry (7248 RLS cases, 19802 controls)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None vs: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention 効果: None None

対象集団: Obese C57 mice with DSS-induced UC

Randomized Controlled Trial

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …

Dose: BCM or ADM seeded with PRP-grown fibroblasts vs: Free gingival grafts (FGG) Outcome: Wound healing of mucogingival defects 効果: None None

対象集団: Animal model (mucogingival defects)

Systematic Review

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.

Dose: None vs: None Outcome: Sleep quality 効果: None None

対象集団: None

In Vitro

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.

Dose: B. amylolyquefaciens B65 lipopeptides vs: None Outcome: Surfactant and antibacterial properties 効果: None None

対象集団: In vitro industrial microbiology study

Other n=10 8 weeks Open-label

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …

Dose: 200 mg vs: Placebo Outcome: Quality of life 効果: None P = .006

対象集団: None

Key Statistics

研究数

8833

参加者数

↔

Mixed

グレード

Referenced Papers

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 件の引用

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. Other

Journal of clinical … 2024 6 件の引用

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 件の引用

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. Other

World journal of … 2024 2 件の引用

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … Other

Journal of periodontal … 2024

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 件の引用

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … RCT

Redox biology 2023 5 件の引用

Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. Other

Animal bioscience 2023 3 件の引用

A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

Neurological research 2023

Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

Nutrients 2023

Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. Other

Frontiers in microbiology 2022 27 件の引用

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. RCT

BMC complementary medicine … 2022 16 件の引用

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 件の引用

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 件の引用

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 件の引用

Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. Other

Biological trace element … 2021 17 件の引用

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. Other

Nutrients 2021 11 件の引用

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 件の引用

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

Reumatismo 2020 21 件の引用

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 件の引用

Iodine and folate-essential for mothers to be. Other

The lancet. Diabetes … 2020 2 件の引用

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. Other

Sleep 2019 38 件の引用

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. Systematic Review

Sleep medicine reviews 2019 23 件の引用

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Other

Nutrients 2019 23 件の引用

Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in … Observational

BMJ open 2019 7 件の引用

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … RCT

Journal of medicinal … 2018 37 件の引用

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. Other

Experimental eye research 2018 33 件の引用

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands. Other

PloS one 2018 11 件の引用

Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. Other

Journal of cellular … 2017 12 件の引用

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 件の引用

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 件の引用

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 件の引用

Magnesium deficiency: a possible cause of restless leg syndrome in haemodialysis patients. Other

Internal medicine journal 2015 5 件の引用

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 件の引用

[Differential diagnosis and treatment of cramps]. Review

MMW Fortschritte der … 2013 3 件の引用

Nocturnal leg cramps. Review

American family physician 2012

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 件の引用

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 件の引用

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 件の引用

Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Other

Skin research and … 2008 67 件の引用

Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studies. Other

Sleep medicine 2007 18 件の引用

Sources of folate and serum folate levels in older adults. Other

Journal of the … 2007 10 件の引用

Epithelial regeneration from bioengineered skin explants in culture. Other

The British journal … 2006 29 件の引用

Intravenous magnesium sulfate may relieve restless legs syndrome in pregnancy. Case Report

Journal of clinical … 2006

Role of medications in the etiology and treatment of restless leg syndrome. Other

Home healthcare nurse 2005 3 件の引用

Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--. Other

Neurophysiologie clinique = … 2004 31 件の引用

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 件の引用

P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

American journal of … 2004

Ketamine for restless legs syndrome. Other

Anesthesia and analgesia 2003 1 件の引用

The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

Medical hypotheses 2002

Phosphatidylethanolamine deficiency in membrane lipids inhibits keratinocyte intercellular networks formation. Other

In vitro cellular … 2001 14 件の引用

Secondary periodic limb movement disorder and restless legs syndrome. Other

Sleep medicine reviews 1999 31 件の引用

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Other

Sleep 1998 108 件の引用

Characterization of epithelial primary cultures from human conjunctiva. Other

Graefe's archive for … 1997 33 件の引用

Carcinosarcoma of the skin. Case report and literature review. Case Report

The American Journal … 1996 1 件の引用

Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Other

Electrophoresis 1995 57 件の引用

Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Other

Romanian journal of … 1993 25 件の引用

The establishment and continuous subculturing of normal human adult hepatocytes: expression of differentiated liver functions. Other

Cell biology and … 1993 10 件の引用

Clonal growth of epithelial cells from normal adult human bronchus. Other

Cancer research 1981 204 件の引用

Restless legs syndrome. Sleep-electroencephalographic and neurologic findings. Other

JAMA 1974 21 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 200-400 mg elemental Mg, before bed

上限量： 350 mg/day (supplemental Mg)

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
None	--	Positive	--
BCM or ADM seeded with PRP-grown fibroblasts	--	Positive	--
None	--	Positive	--
B. amylolyquefaciens B65 lipopeptides	--	Neutral	--
200 mg	8 weeks	Mixed	10
5 g	--	Positive	--
None	--	Mixed	--

推奨摂取タイミング： 30-60 minutes before bed

Safety & Side Effects

報告されている副作用

⚠ Loose stools or diarrhea
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure at high doses

既知の相互作用

● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
● Bisphosphonates — magnesium may decrease efficacy
● Blood pressure medications — additive hypotensive effects

耐容上限摂取量： 350 mg/day (supplemental Mg)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does グリシン酸マグネシウム help with むずむず脚症候群?

Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that グリシン酸マグネシウム may support むずむず脚症候群 management. Our evidence grade is F (Evidence Against).

How much グリシン酸マグネシウム should I take for むずむず脚症候群?

Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of グリシン酸マグネシウム?

Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for グリシン酸マグネシウム and むずむず脚症候群?

We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.

Related Evidence

に関する他の成分：むずむず脚症候群

鉄 A

グリシン酸マグネシウム他の症状・状態について

入眠困難 A 不眠症 A 不安に伴う睡眠障害 B

総合評価

合計31,304名の参加者を対象とした25件の研究（メタアナリシス3件、RCT 1件を含む）に基づく。25件中15件の研究で肯定的な効果が示されている。

Evidence Strength10%

Low confidence

研究の内訳

RCT (4)Meta (0)Other (50)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：むずむず脚症候群

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。