Magnesium Glycinate cho Hội Chứng Chân Không Yên
F Hiệu quả Nghiên cứu cho thấy điều này khó có khả năng hiệu quả cho mục đích sử dụng này.Dựa trên 25 nghiên cứu (3 meta-analyses, 1 RCT) với 31,304 người tham gia. 15/25 nghiên cứu cho thấy tác động tích cực.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'sleepcited.com';
const params = 'ingredient\u003Dmagnesium\u002Dglycinate\u0026condition\u003Drestless\u002Dleg\u002Dsyndrome';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
F
Kết luận
Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.
- 15 out of 25 studies show positive effects with 31,304 participants across all study types
- A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
- Low magnesium levels are consistently associated with higher RLS risk
- Particularly relevant for pregnant women and kidney disease patients with RLS
Key Study Findings
Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None
so với: None
Outcome: Causal association of micronutrients with RLS
Hiệu quả: Retinol OR 0.46; Mg OR 0.62
None
Đối tượng nghiên cứu: European ancestry (7248 RLS cases, 19802 controls)
Other
Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.
Dose: None
so với: Uncoated EcN and UC model mice
Outcome: UC inflammation and probiotic intestinal retention
Hiệu quả: None
None
Đối tượng nghiên cứu: Obese C57 mice with DSS-induced UC
Randomized Controlled Trial
Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …
Dose: BCM or ADM seeded with PRP-grown fibroblasts
so với: Free gingival grafts (FGG)
Outcome: Wound healing of mucogingival defects
Hiệu quả: None
None
Đối tượng nghiên cứu: Animal model (mucogingival defects)
Systematic Review
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.
Dose: None
so với: None
Outcome: Sleep quality
Hiệu quả: None
None
Đối tượng nghiên cứu: None
In Vitro
Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.
Dose: B. amylolyquefaciens B65 lipopeptides
so với: None
Outcome: Surfactant and antibacterial properties
Hiệu quả: None
None
Đối tượng nghiên cứu: In vitro industrial microbiology study
Other
n=10
8 weeks
Open-label
Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …
Dose: 200 mg
so với: Placebo
Outcome: Quality of life
Hiệu quả: None
P = .006
Đối tượng nghiên cứu: None
Key Statistics
54
Nghiên cứu
8833
Người tham gia
↔
Mixed
F
Xếp hạng
Referenced Papers
Colloids and surfaces. …
2025
4 trích dẫn
Food science & …
2025
Journal of clinical …
2024
6 trích dẫn
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.
Systematic Review
Nutrients
2024
5 trích dẫn
Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.
Other
World journal of …
2024
2 trích dẫn
Journal of periodontal …
2024
Cureus
2023
6 trích dẫn
Redox biology
2023
5 trích dẫn
Animal bioscience
2023
3 trích dẫn
Neurological research
2023
Nutrients
2023
Frontiers in microbiology
2022
27 trích dẫn
BMC complementary medicine …
2022
16 trích dẫn
Antioxidants (Basel, Switzerland)
2022
13 trích dẫn
Sleep science (Sao …
2022
12 trích dẫn
The British journal …
2022
7 trích dẫn
Biological trace element …
2021
17 trích dẫn
Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo.
Other
Nutrients
2021
11 trích dẫn
Sleep
2021
10 trích dẫn
Reumatismo
2020
21 trích dẫn
Biological trace element …
2020
10 trích dẫn
The lancet. Diabetes …
2020
2 trích dẫn
Sleep
2019
38 trích dẫn
Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review.
Systematic Review
Sleep medicine reviews
2019
23 trích dẫn
Nutrients
2019
23 trích dẫn
BMJ open
2019
7 trích dẫn
Journal of medicinal …
2018
37 trích dẫn
Experimental eye research
2018
33 trích dẫn
PloS one
2018
11 trích dẫn
Journal of cellular …
2017
12 trích dẫn
A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women.
Other
The journal of …
2017
8 trích dẫn
Cytotechnology
2016
18 trích dẫn
Sleep & breathing …
2015
22 trích dẫn
Internal medicine journal
2015
5 trích dẫn
Kidney & blood …
2013
43 trích dẫn
MMW Fortschritte der …
2013
3 trích dẫn
Nocturnal leg cramps.
Review
American family physician
2012
Applied and environmental …
2009
105 trích dẫn
Journal of basic …
2009
54 trích dẫn
Movement disorders : …
2008
309 trích dẫn
Skin research and …
2008
67 trích dẫn
Sleep medicine
2007
18 trích dẫn
Journal of the …
2007
10 trích dẫn
The British journal …
2006
29 trích dẫn
Journal of clinical …
2006
Home healthcare nurse
2005
3 trích dẫn
Neurophysiologie clinique = …
2004
31 trích dẫn
Neurologia i neurochirurgia …
2004
2 trích dẫn
American journal of …
2004
Anesthesia and analgesia
2003
1 trích dẫn
Medical hypotheses
2002
In vitro cellular …
2001
14 trích dẫn
Sleep medicine reviews
1999
31 trích dẫn
Sleep
1998
108 trích dẫn
Graefe's archive for …
1997
33 trích dẫn
The American Journal …
1996
1 trích dẫn
Electrophoresis
1995
57 trích dẫn
Romanian journal of …
1993
25 trích dẫn
Cell biology and …
1993
10 trích dẫn
Cancer research
1981
204 trích dẫn
JAMA
1974
21 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 200-400 mg elemental Mg, before bed
Giới hạn trên: 350 mg/day (supplemental Mg)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| BCM or ADM seeded with PRP-grown fibroblasts | -- | Positive | -- |
| None | -- | Positive | -- |
| B. amylolyquefaciens B65 lipopeptides | -- | Neutral | -- |
| 200 mg | 8 weeks | Mixed | 10 |
| 5 g | -- | Positive | -- |
| None | -- | Mixed | -- |
Thời điểm dùng tốt nhất: 30-60 minutes before bed
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Loose stools or diarrhea
- ⚠ Nausea
- ⚠ Abdominal cramping
- ⚠ Low blood pressure at high doses
Tương tác đã biết
- ● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
- ● Bisphosphonates — magnesium may decrease efficacy
- ● Blood pressure medications — additive hypotensive effects
Mức hấp thụ tối đa cho phép: 350 mg/day (supplemental Mg)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Magnesium Glycinate help with Hội Chứng Chân Không Yên?
Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that Magnesium Glycinate may support Hội Chứng Chân Không Yên management. Our evidence grade is F (Evidence Against).
How much Magnesium Glycinate should I take for Hội Chứng Chân Không Yên?
Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Magnesium Glycinate?
Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Magnesium Glycinate and Hội Chứng Chân Không Yên?
We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.
Related Evidence
Các thành phần khác cho Hội Chứng Chân Không Yên
Magnesium Glycinate cho các tình trạng khác
References
- [1] Xie Chengfeng et al.. Colloids Surf B Biointerfaces. 2025. Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. doi:10.1016/j.colsurfb.2025.115035 PubMed
- [2] Yun Lin et al.. Food Sci Nutr. 2025. Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. doi:10.1002/fsn3.70568 PubMed
- [3] Sasikanth Gorantla et al.. J Clin Sleep Med. 2024. Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. doi:10.5664/jcsm.11206 PubMed
- [4] Pedro González-Parejo et al.. Nutrients. 2024. Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. doi:10.3390/nu16142315 PubMed
- [5] Inés María Virgili Alemán et al.. World J Microbiol Biotechnol. 2024. Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. doi:10.1007/s11274-024-04215-4 PubMed
- [6] Abraão Moratelli Prado et al.. J Periodontal Implant Sci. 2024. Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … doi:10.5051/jpis.2200940047 PubMed
- [7] Hasan Turan et al.. Cureus. 2023. The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. doi:10.7759/cureus.44884 PubMed
- [8] W M Peeters et al.. Redox Biol. 2023. Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … doi:10.1016/j.redox.2023.102918 PubMed
- [9] Man Zhao et al.. Anim Biosci. 2023. Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. doi:10.5713/ab.22.0286 PubMed
- [10] Duygu Seyhan Erdoğan et al.. Neurol Res. 2023. A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? doi:10.1080/01616412.2023.2257443 PubMed
- [11] Silvia Preciado et al.. Nutrients. 2023. Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. doi:10.3390/nu15214582 PubMed
- [12] Chhavi Sharma et al.. Front Microbiol. 2022. Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. doi:10.3389/fmicb.2022.882902 PubMed
- [13] Ali Jadidi et al.. BMC Complement Med Ther. 2022. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. doi:10.1186/s12906-022-03814-8 PubMed
- [14] Félix Javier Jiménez-Jiménez et al.. Antioxidants (Basel). 2022. Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. doi:10.3390/antiox11020272 PubMed
- [15] Ana Mendes et al.. Sleep Sci. 2022. Possible etiologies of restless legs syndrome in pregnancy: a narrative review. doi:10.5935/1984-0063.20220080 PubMed
- [16] Taeko Suzuki et al.. Br J Nutr. 2022. Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … doi:10.1017/S000711452200037X PubMed
- [17] Engin Yıldırım et al.. Biol Trace Elem Res. 2021. Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. doi:10.1007/s12011-020-02287-5 PubMed
- [18] Kyohei Furukawa et al.. Nutrients. 2021. Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. doi:10.3390/nu13072144 PubMed
- [19] Pan Chen et al.. Sleep. 2021. A potential role for zinc in restless legs syndrome. doi:10.1093/sleep/zsaa236 PubMed
- [20] F Oliviero et al.. Reumatismo. 2020. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … doi:10.4081/reumatismo.2020.1272 PubMed
- [21] Akram Zarbalizadeh-Saed et al.. Biol Trace Elem Res. 2020. Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … doi:10.1007/s12011-019-01853-w PubMed
- [22] Malcolm Prentice et al.. Lancet Diabetes Endocrinol. 2020. Iodine and folate-essential for mothers to be. doi:10.1016/S2213-8587(19)30380-8 PubMed
- [23] András Szentkirályi et al.. Sleep. 2019. Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. doi:10.1093/sleep/zsy237 PubMed
- [24] Nathaniel S Marshall et al.. Sleep Med Rev. 2019. Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. doi:10.1016/j.smrv.2019.101218 PubMed
- [25] Marialuisa Piccolo et al.. Nutrients. 2019. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. doi:10.3390/nu11123041 PubMed
- [26] Yi Yang et al.. BMJ Open. 2019. Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in … doi:10.1136/bmjopen-2018-027970 PubMed
- [27] Gian Carlo Tenore et al.. J Med Food. 2018. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … doi:10.1089/jmf.2017.0016 PubMed
- [28] Lorenz Latta et al.. Exp Eye Res. 2018. Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. doi:10.1016/j.exer.2017.11.005 PubMed
- [29] Vicky T Nguyen et al.. PLoS One. 2018. Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands. doi:10.1371/journal.pone.0193942 PubMed
- [30] Kyoumi Shirai et al.. J Cell Biochem. 2017. Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. doi:10.1002/jcb.25734 PubMed
- [31] İrfan Ozer et al.. J Matern Fetal Neonatal Med. 2017. A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. doi:10.3109/14767058.2016.1170801 PubMed
- [32] Renfu Quan et al.. Cytotechnology. 2016. Culture and characterization of rat hair follicle stem cells. doi:10.1007/s10616-014-9807-z PubMed
- [33] Hasan Terzi et al.. Sleep Breath. 2015. Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. doi:10.1007/s11325-014-0964-2 PubMed
- [34] D Sinniah. Intern Med J. 2015. Magnesium deficiency: a possible cause of restless leg syndrome in haemodialysis patients. doi:10.1111/imj.12715 PubMed
- [35] Katrin Gade et al.. Kidney Blood Press Res. 2013. Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … doi:10.1159/000355727 PubMed
- [36] H C Diener et al.. MMW Fortschr Med. 2013. [Differential diagnosis and treatment of cramps]. doi:10.1007/s15006-013-2187-z PubMed
- [37] Richard E Allen et al.. Am Fam Physician. 2012. Nocturnal leg cramps. PubMed
- [38] Ilya V Kublanov et al.. Appl Environ Microbiol. 2009. Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). doi:10.1128/AEM.00607-08 PubMed
- [39] Ashraf S A El-Sayed. J Basic Microbiol. 2009. L-methioninase production by Aspergillus flavipes under solid-state fermentation. doi:10.1002/jobm.200800318 PubMed
- [40] Claudia Trenkwalder et al.. Mov Disord. 2008. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. doi:10.1002/mds.22254 PubMed
- [41] C Barba et al.. Skin Res Technol. 2008. Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. doi:10.1111/j.1600-0846.2007.00280.x PubMed
- [42] Arthur S Walters et al.. Sleep Med. 2007. Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studies. doi:10.1016/j.sleep.2006.07.001 PubMed
- [43] Jessica E Mulligan et al.. J Am Diet Assoc. 2007. Sources of folate and serum folate levels in older adults. doi:10.1016/j.jada.2006.12.001 PubMed
- [44] U Mirastschijski et al.. Br J Dermatol. 2006. Epithelial regeneration from bioengineered skin explants in culture. doi:10.1111/j.1365-2133.2005.06997.x PubMed
- [45] Sharon Bartell et al.. J Clin Sleep Med. 2006. Intravenous magnesium sulfate may relieve restless legs syndrome in pregnancy. PubMed
- [46] Patricia J Neafsey. Home Healthc Nurse. 2005. Role of medications in the etiology and treatment of restless leg syndrome. doi:10.1097/00004045-200504000-00003 PubMed
- [47] E Freye et al.. Neurophysiol Clin. 2004. Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--. doi:10.1016/j.neucli.2004.02.002 PubMed
- [48] Luiza Jonczak et al.. Neurol Neurochir Pol. 2004. [Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. PubMed
- [49] Zhong Jiang et al.. Am J Clin Pathol. 2004. P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. doi:10.1309/7T7R-JCCL-84JG-XH3L PubMed
- [50] Robert Friedman. Anesth Analg. 2003. Ketamine for restless legs syndrome. doi:10.1213/01.ANE.0000048364.63828.0A PubMed
- [51] B L Grimaldi. Med Hypotheses. 2002. The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … doi:10.1054/mehy.2001.1447 PubMed
- [52] T Kano-Sueoka et al.. In Vitro Cell Dev Biol Anim. 2001. Phosphatidylethanolamine deficiency in membrane lipids inhibits keratinocyte intercellular networks formation. doi:10.1290/1071-2690(2001)037<0691:PDIMLI>2.0.CO;2 PubMed
- [53] R M Rijsman et al.. Sleep Med Rev. 1999. Secondary periodic limb movement disorder and restless legs syndrome. doi:10.1016/s1087-0792(99)90021-7 PubMed
- [54] M Hornyak et al.. Sleep. 1998. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. doi:10.1093/sleep/21.5.501 PubMed
- [55] Y Diebold et al.. Graefes Arch Clin Exp Ophthalmol. 1997. Characterization of epithelial primary cultures from human conjunctiva. doi:10.1007/BF01739635 PubMed
- [56] W Biernat et al.. Am J Dermatopathol. 1996. Carcinosarcoma of the skin. Case report and literature review. doi:10.1097/00000372-199612000-00012 PubMed
- [57] E Olsen et al.. Electrophoresis. 1995. Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. doi:10.1002/elps.11501601356 PubMed
- [58] L Popoviciu et al.. Rom J Neurol Psychiatry. 1993. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. PubMed
- [59] R E Gibson-D'Ambrosio et al.. Cell Biol Toxicol. 1993. The establishment and continuous subculturing of normal human adult hepatocytes: expression of differentiated liver functions. doi:10.1007/BF00754467 PubMed
- [60] J F Lechner et al.. Cancer Res. 1981. Clonal growth of epithelial cells from normal adult human bronchus. PubMed
- [61] B L Frankel et al.. JAMA. 1974. Restless legs syndrome. Sleep-electroencephalographic and neurologic findings. doi:10.1001/jama.230.9.1302 PubMed
Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.