Magnesium Glycinate cho Hội Chứng Chân Không Yên

Dựa trên 25 nghiên cứu (3 meta-analyses, 1 RCT) với 31,304 người tham gia. 15/25 nghiên cứu cho thấy tác động tích cực.

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Kết luận

Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.

15 out of 25 studies show positive effects with 31,304 participants across all study types
A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
Low magnesium levels are consistently associated with higher RLS risk
Particularly relevant for pregnant women and kidney disease patients with RLS

Key Study Findings

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None so với: None Outcome: Causal association of micronutrients with RLS Hiệu quả: Retinol OR 0.46; Mg OR 0.62 None

Đối tượng nghiên cứu: European ancestry (7248 RLS cases, 19802 controls)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None so với: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention Hiệu quả: None None

Đối tượng nghiên cứu: Obese C57 mice with DSS-induced UC

Randomized Controlled Trial

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …

Dose: BCM or ADM seeded with PRP-grown fibroblasts so với: Free gingival grafts (FGG) Outcome: Wound healing of mucogingival defects Hiệu quả: None None

Đối tượng nghiên cứu: Animal model (mucogingival defects)

Systematic Review

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.

Dose: None so với: None Outcome: Sleep quality Hiệu quả: None None

Đối tượng nghiên cứu: None

In Vitro

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.

Dose: B. amylolyquefaciens B65 lipopeptides so với: None Outcome: Surfactant and antibacterial properties Hiệu quả: None None

Đối tượng nghiên cứu: In vitro industrial microbiology study

Other n=10 8 weeks Open-label

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …

Dose: 200 mg so với: Placebo Outcome: Quality of life Hiệu quả: None P = .006

Đối tượng nghiên cứu: None

Key Statistics

Nghiên cứu

8833

Người tham gia

↔

Mixed

Xếp hạng

Referenced Papers

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 trích dẫn

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. Other

Journal of clinical … 2024 6 trích dẫn

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 trích dẫn

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. Other

World journal of … 2024 2 trích dẫn

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … Other

Journal of periodontal … 2024

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 trích dẫn

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … RCT

Redox biology 2023 5 trích dẫn

Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. Other

Animal bioscience 2023 3 trích dẫn

A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

Neurological research 2023

Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

Nutrients 2023

Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. Other

Frontiers in microbiology 2022 27 trích dẫn

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. RCT

BMC complementary medicine … 2022 16 trích dẫn

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 trích dẫn

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 trích dẫn

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 trích dẫn

Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. Other

Biological trace element … 2021 17 trích dẫn

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. Other

Nutrients 2021 11 trích dẫn

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 trích dẫn

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

Reumatismo 2020 21 trích dẫn

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 trích dẫn

Iodine and folate-essential for mothers to be. Other

The lancet. Diabetes … 2020 2 trích dẫn

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies. Other

Sleep 2019 38 trích dẫn

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review. Systematic Review

Sleep medicine reviews 2019 23 trích dẫn

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Other

Nutrients 2019 23 trích dẫn

Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in … Observational

BMJ open 2019 7 trích dẫn

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … RCT

Journal of medicinal … 2018 37 trích dẫn

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. Other

Experimental eye research 2018 33 trích dẫn

Administration of growth factors promotes salisphere formation from irradiated parotid salivary glands. Other

PloS one 2018 11 trích dẫn

Hypoxia Enhances Differentiation of Hair Follicle-Associated-Pluripotent (HAP) Stem Cells to Cardiac-Muscle Cells. Other

Journal of cellular … 2017 12 trích dẫn

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 trích dẫn

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 trích dẫn

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 trích dẫn

Magnesium deficiency: a possible cause of restless leg syndrome in haemodialysis patients. Other

Internal medicine journal 2015 5 trích dẫn

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 trích dẫn

[Differential diagnosis and treatment of cramps]. Review

MMW Fortschritte der … 2013 3 trích dẫn

Nocturnal leg cramps. Review

American family physician 2012

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 trích dẫn

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 trích dẫn

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 trích dẫn

Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids derived from wool. Other

Skin research and … 2008 67 trích dẫn

Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studies. Other

Sleep medicine 2007 18 trích dẫn

Sources of folate and serum folate levels in older adults. Other

Journal of the … 2007 10 trích dẫn

Epithelial regeneration from bioengineered skin explants in culture. Other

The British journal … 2006 29 trích dẫn

Intravenous magnesium sulfate may relieve restless legs syndrome in pregnancy. Case Report

Journal of clinical … 2006

Role of medications in the etiology and treatment of restless leg syndrome. Other

Home healthcare nurse 2005 3 trích dẫn

Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--. Other

Neurophysiologie clinique = … 2004 31 trích dẫn

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 trích dẫn

P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

American journal of … 2004

Ketamine for restless legs syndrome. Other

Anesthesia and analgesia 2003 1 trích dẫn

The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

Medical hypotheses 2002

Phosphatidylethanolamine deficiency in membrane lipids inhibits keratinocyte intercellular networks formation. Other

In vitro cellular … 2001 14 trích dẫn

Secondary periodic limb movement disorder and restless legs syndrome. Other

Sleep medicine reviews 1999 31 trích dẫn

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Other

Sleep 1998 108 trích dẫn

Characterization of epithelial primary cultures from human conjunctiva. Other

Graefe's archive for … 1997 33 trích dẫn

Carcinosarcoma of the skin. Case report and literature review. Case Report

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Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Other

Electrophoresis 1995 57 trích dẫn

Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Other

Romanian journal of … 1993 25 trích dẫn

The establishment and continuous subculturing of normal human adult hepatocytes: expression of differentiated liver functions. Other

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Clonal growth of epithelial cells from normal adult human bronchus. Other

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 200-400 mg elemental Mg, before bed

Giới hạn trên: 350 mg/day (supplemental Mg)

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Mixed	--
None	--	Positive	--
BCM or ADM seeded with PRP-grown fibroblasts	--	Positive	--
None	--	Positive	--
B. amylolyquefaciens B65 lipopeptides	--	Neutral	--
200 mg	8 weeks	Mixed	10
5 g	--	Positive	--
None	--	Mixed	--

Thời điểm dùng tốt nhất: 30-60 minutes before bed

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Loose stools or diarrhea
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure at high doses

Tương tác đã biết

● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
● Bisphosphonates — magnesium may decrease efficacy
● Blood pressure medications — additive hypotensive effects

Mức hấp thụ tối đa cho phép: 350 mg/day (supplemental Mg)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Magnesium Glycinate help with Hội Chứng Chân Không Yên?

Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that Magnesium Glycinate may support Hội Chứng Chân Không Yên management. Our evidence grade is F (Evidence Against).

How much Magnesium Glycinate should I take for Hội Chứng Chân Không Yên?

Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Magnesium Glycinate?

Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Magnesium Glycinate and Hội Chứng Chân Không Yên?

We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.

Related Evidence

Các thành phần khác cho Hội Chứng Chân Không Yên

Sắt A

Magnesium Glycinate cho các tình trạng khác

Khó Đi Vào Giấc Ngủ A Mất Ngủ A Vấn Đề Giấc Ngủ Do Lo Âu B

Đánh giá nhanh

Dựa trên 25 nghiên cứu (3 meta-analyses, 1 RCT) với 31,304 người tham gia. 15/25 nghiên cứu cho thấy tác động tích cực.

Evidence Strength10%

Low confidence

Phân tích nghiên cứu

RCT (4)Meta (0)Other (50)

So sánh lựa chọn thay thế

Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho Hội Chứng Chân Không Yên

Tìm hiểu thêm

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.