Magnesium Glycinate لـ متلازمة تململ الساقين

بناءً على 25 دراسة (3 meta-analyses, 1 RCT) بمشاركة 31,304 مشاركًا إجمالاً. 15/25 دراسة تُظهر تأثيرات إيجابية.

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الخلاصة

Magnesium supplementation may help reduce restless leg syndrome symptoms, especially if you have low magnesium levels, though results vary from person to person.

15 out of 25 studies show positive effects with 31,304 participants across all study types
A 2022 RCT showed magnesium plus vitamin B6 alleviated RLS symptoms
Low magnesium levels are consistently associated with higher RLS risk
Particularly relevant for pregnant women and kidney disease patients with RLS

Key Study Findings

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None مقابل: None Outcome: Causal association of micronutrients with RLS التأثير: Retinol OR 0.46; Mg OR 0.62 None

المجتمع المدروس: European ancestry (7248 RLS cases, 19802 controls)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None مقابل: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention التأثير: None None

المجتمع المدروس: Obese C57 mice with DSS-induced UC

Randomized Controlled Trial

Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented …

Dose: BCM or ADM seeded with PRP-grown fibroblasts مقابل: Free gingival grafts (FGG) Outcome: Wound healing of mucogingival defects التأثير: None None

المجتمع المدروس: Animal model (mucogingival defects)

Systematic Review

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.

Dose: None مقابل: None Outcome: Sleep quality التأثير: None None

المجتمع المدروس: None

In Vitro

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery.

Dose: B. amylolyquefaciens B65 lipopeptides مقابل: None Outcome: Surfactant and antibacterial properties التأثير: None None

المجتمع المدروس: In vitro industrial microbiology study

Other n=10 8 weeks Open-label

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in …

Dose: 200 mg مقابل: Placebo Outcome: Quality of life التأثير: None P = .006

المجتمع المدروس: None

Key Statistics

الدراسات

8833

المشاركون

↔

Mixed

التقييم

Referenced Papers

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 اقتباسات

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. Other

Journal of clinical … 2024 6 اقتباسات

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 اقتباسات

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Bacterial cellulose matrix and acellular dermal matrix seeded with fibroblasts grown in platelet-rich plasma supplemented medium, compared to free gingival … Other

Journal of periodontal … 2024

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 اقتباسات

Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot … RCT

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Dietary methionine supplementation to a low-protein diet improved hair follicle development of Angora rabbits. Other

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A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

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Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

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Chicken Feather Waste Valorization Into Nutritive Protein Hydrolysate: Role of Novel Thermostable Keratinase From Bacillus pacificus RSA27. Other

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Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. RCT

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Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 اقتباسات

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 اقتباسات

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

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Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study. Other

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Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo. Other

Nutrients 2021 11 اقتباسات

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 اقتباسات

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

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Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Other

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Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in … RCT

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 200-400 mg elemental Mg, before bed

الحد الأعلى: 350 mg/day (supplemental Mg)

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Mixed	--
None	--	Positive	--
BCM or ADM seeded with PRP-grown fibroblasts	--	Positive	--
None	--	Positive	--
B. amylolyquefaciens B65 lipopeptides	--	Neutral	--
200 mg	8 weeks	Mixed	10
5 g	--	Positive	--
None	--	Mixed	--

أفضل وقت للتناول: 30-60 minutes before bed

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Loose stools or diarrhea
⚠ Nausea
⚠ Abdominal cramping
⚠ Low blood pressure at high doses

التفاعلات المعروفة

● Antibiotics (tetracyclines, fluoroquinolones) — may reduce absorption
● Bisphosphonates — magnesium may decrease efficacy
● Blood pressure medications — additive hypotensive effects

الحد الأقصى المسموح به: 350 mg/day (supplemental Mg)

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Magnesium Glycinate help with متلازمة تململ الساقين?

Based on 54 studies with 8,833 participants, there is insufficient evidence at this time that Magnesium Glycinate may support متلازمة تململ الساقين management. Our evidence grade is F (Evidence Against).

How much Magnesium Glycinate should I take for متلازمة تململ الساقين?

Studies have used various dosages. A commonly studied range is 200-400 mg elemental Mg, before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Magnesium Glycinate?

Reported side effects may include Loose stools or diarrhea, Nausea, Abdominal cramping, Low blood pressure at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Magnesium Glycinate and متلازمة تململ الساقين?

We rate the evidence as Grade F (Evidence Against). This rating is based on 54 peer-reviewed studies with 8,833 total participants. The overall direction of effect is mixed.

Related Evidence

مكونات أخرى لـ متلازمة تململ الساقين

الحديد A

Magnesium Glycinate لحالات أخرى

صعوبة بدء النوم A الأرق A مشاكل النوم المرتبطة بالقلق B

الخلاصة السريعة

بناءً على 25 دراسة (3 meta-analyses, 1 RCT) بمشاركة 31,304 مشاركًا إجمالاً. 15/25 دراسة تُظهر تأثيرات إيجابية.

Evidence Strength10%

Low confidence

تفصيل الدراسات

RCT (4)Meta (0)Other (50)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ متلازمة تململ الساقين

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.