Disorders of heavy metals.
Study Design
- अध्ययन प्रकार
- Review
- हस्तक्षेप
- Disorders of heavy metals. None
- तुलनित्र
- Placebo
- प्रभाव की दिशा
- Neutral
- पूर्वाग्रह का जोखिम
- Unclear
Abstract
Heavy metals and trace elements play an important role in relation to the physiology and pathology of the nervous system. Neurologic diseases related to disorders of metabolism of copper and iron are reviewed. Copper disorders are divided into two classes: ATP7A- or ATP7B-related inherited copper transport disorders (Menkes disease, occipital horn syndrome, ATP7A-related distal motor neuropathy, and Wilson disease) and acquired diseases associated with copper deficiency or copper excess. Iron brain disorders are divided into genetic neurodegeneration with brain iron accumulation (NBIA, neuroferritinopathy, and aceruloplasminemia), genetic systemic iron accumulation with neurologic features (hemochromatosis), and acquired diseases associated with iron excess (superficial siderosis) or iron deficiency (restless leg syndrome). The main features of cadmium, lead, aluminum, mercury, and manganese toxicity are summarized.
Used In Evidence Reviews
Similar Papers
Sleep medicine · 2004
Dopamine and iron in the pathophysiology of restless legs syndrome (RLS).
Neurology · 2004
Restless legs syndrome and pregnancy.
Movement disorders : official journal of the Movement Disorder Society · 2008
Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice.
Nature reviews. Neurology · 2010
Restless legs syndrome: pathophysiology, clinical presentation and management.
Sleep medicine · 2014
Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).
Sleep medicine · 2016