Zat Besi untuk Sindrom Kaki Gelisah

Q: Does Zat Besi help with Sindrom Kaki Gelisah?

Based on 173 studies with 36,638 participants, there is strong evidence from multiple clinical trials that Zat Besi may support Sindrom Kaki Gelisah management. Our evidence grade is A (Strong Evidence).

Q: How much Zat Besi should I take for Sindrom Kaki Gelisah?

Studies have used various dosages. A commonly studied range is 65 mg elemental iron if ferritin <75. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Zat Besi?

Reported side effects may include Constipation, Nausea, Stomach pain, Dark stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Zat Besi and Sindrom Kaki Gelisah?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 173 peer-reviewed studies with 36,638 total participants. The overall direction of effect is mixed.

Berdasarkan 65 studi (5 meta-analyses) dengan 24,923 peserta secara total. 34/65 studi menunjukkan efek positif.

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Kesimpulan

Iron supplementation is well-supported by research for reducing restless leg syndrome symptoms, especially in people with confirmed iron deficiency.

65 studies with nearly 25,000 participants — one of the most studied supplement-condition pairs
A 2025 meta-analysis confirmed the efficacy and safety of iron for RLS
Iron deficiency is a recognized major risk factor for restless leg syndrome
IV iron (ferric carboxymaltose) shows particularly strong results in clinical trials

Key Study Findings

review

[Restless leg syndrome. Diagnosis and treatment].

Dose: various vs: Placebo Efek: None None

case-control n=90

Restless Leg Syndrome and Association with Serum NT Pro-CNP.

Dose: None vs: Placebo Efek: NT pro-CNP significantly lower in RLS vs controls; sensitivity 80%, specificity 88.9%; serum iron lo None

Cohort Study n=58 Open-label

Efficacy and safety of intravenous iron in patients with restless legs syndrome with normal serum …

Dose: 1000 mg ferric carboxymaltose vs: Group A (ferritin <100) vs Group B (ferritin 100-300) Outcome: IRLS severity scale score change Efek: None None

Populasi: RLS patients with serum ferritin <300 µg/L

review

Restless Leg Syndrome and Pregnancy.

Dose: iron supplementation, folate, dopamine agonists (non-pharmacological and pharmacological) vs: Placebo Efek: None None

review

[Restless Legs Syndrome].

Dose: dopamine agonists, iron supplementation, alpha-2-delta ligands vs: Placebo Efek: None None

review

Optimizing Restless Legs Syndrome Care: Integrating Rehabilitation into Multimodal Management.

Dose: None vs: Placebo Efek: None None

Key Statistics

173

Studi

36638

Peserta

↔

Mixed

Peringkat

Referenced Papers

[Restless leg syndrome. Diagnosis and treatment]. Review

Revista de neurologia None 8 sitasi

Restless Leg Syndrome and Association with Serum NT Pro-CNP. Other

Neurology India 2026

Restless legs syndrome. Pathophysiology, diagnosis and treatment. Review

Medicina clinica 2025 11 sitasi

Restless Legs Syndrome, Periodic Leg Movements, Hypertension and Cardiovascular Diseases. Review

Circulation research 2025 4 sitasi

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 sitasi

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 sitasi

Serum alpha-synuclein in restless legs syndrome. Other

Sleep 2025 3 sitasi

Efficacy and safety of intravenous iron in patients with restless legs syndrome with normal serum ferritin levels: a stratified subanalysis. Other

Journal of clinical … 2025 3 sitasi

Iron Metabolism and the Role of Iron Therapy in Pediatric Restless Leg Syndrome. Review

Sleep medicine clinics 2025 2 sitasi

Restless legs syndrome in Parkinson's disease: epidemiology, pathogenetic overlaps, and clinical management. Review

Journal of neurology 2025 1 sitasi

Restless Legs Syndrome: Neurochemistry and Therapy. Review

Seminars in neurology 2025

Circadian pattern in restless legs syndrome. Review

Handbook of clinical … 2025

Therapy of Childhood Restless Legs Syndrome and Periodic Limb Movement Disorder. Review

Sleep medicine clinics 2025

Restless Leg Syndrome and Pregnancy. Review

Southern medical journal 2025

[Restless Legs Syndrome]. Review

Brain and nerve … 2025

Optimizing Restless Legs Syndrome Care: Integrating Rehabilitation into Multimodal Management. Review

JPMA. The Journal … 2025

Prevalence of Restless Leg Syndrome and Its Association With Iron Deficiency in Patients With Chronic Kidney Disease: A Cross-Sectional Observational … Other

Cureus 2025

Clinical Features of Childhood Restless Legs Syndrome. Review

Sleep medicine clinics 2025

Efficacy and safety of iron supplements for restless leg syndrome, a systematic review, meta-analysis, meta-regression, and trial sequential analysis of … Other

Proceedings (Baylor University. … 2025

Clinical feature and alpha-synuclein level of restless legs syndrome with leucine-rich repeat kinase 2 encoding gene mutation. Other

Parkinsonism & related … 2025

Prevalence and clinical profile of patients with restless legs syndrome in Parkinson's disease: A meta-analysis. Meta-Analysis

Sleep medicine 2024 17 sitasi

Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions. Other

Nutrients 2024 7 sitasi

Rethinking clinical trials in restless legs syndrome: A roadmap. Review

Sleep medicine reviews 2024 6 sitasi

A randomized double-blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the … RCT

American journal of … 2024 6 sitasi

Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review. Systematic Review

Nutrients 2024 5 sitasi

Efficacy of intravenous iron for restless legs syndrome-moving beyond monotherapy and into the "real world". Other

Sleep 2024 4 sitasi

Brain Iron Dysregulation in Iron Deficiency Anemia-Related Restless Leg Syndrome Revealed by Neuron-Derived Extracellular Vesicles: A Case-Control Study. Other

Annals of neurology 2024 3 sitasi

Biotechnological properties of Bacillus amylolyquefaciens B65 isolated from an artisanal tannery. Other

World journal of … 2024 2 sitasi

Iron deficiency-related symptoms in non-anemic whole blood donors. Other

Transfusion 2024 2 sitasi

Clinical efficacy and safety of IV ferric carboxymaltose in restless legs syndrome: A meta-analysis of 537 patients. Meta-Analysis

Sleep medicine 2024 1 sitasi

Restless legs syndrome, neuroleptic-induced akathisia, and the iron opioid dopamine link. Other

Sleep 2024 1 sitasi

Current and emerging pharmaceutical strategies for the treatment and management of restless legs syndrome. Review

Expert review of … 2024 1 sitasi

Intersecting Pathways: Treating Cocaine Withdrawal and Restless Leg Syndrome with Iron and Buproprion. Case Report

Healthcare (Basel, Switzerland) 2024

Sleep-related disorders in patients with precapillary pulmonary hypertension. Review

Sleep medicine reviews 2024

Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review. Systematic Review

Tremor and other … 2023 32 sitasi

Vitamin D and Restless Legs Syndrome: A Review of Current Literature. Review

Tremor and other … 2023 22 sitasi

Restless Legs Syndrome and Restless Sleep Disorder in Children. Review

Sleep medicine clinics 2023 14 sitasi

Restless leg syndrome in patients with chronic kidney disease: a hospital-based study from Upper Egypt. Other

The International journal … 2023 14 sitasi

Restless leg syndrome in rheumatic conditions: Its prevalence and risk factors, a meta-analysis. Meta-Analysis

International journal of … 2023 13 sitasi

The genetic etiology of periodic limb movement in sleep. Meta-Analysis

Sleep 2023 8 sitasi

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy. Other

Cureus 2023 6 sitasi

The Prevalence of Restless Legs Syndrome Among Pregnant Women in Saudi Arabia. Other

Cureus 2023 3 sitasi

Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: Implications on the dopaminergic system and PTPRD. Other

Sleep medicine 2023 3 sitasi

Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders. Review

Continuum (Minneapolis, Minn.) 2023 2 sitasi

Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease. Other

Nutrients 2023

Restless legs syndrome: From clinic to personalized medicine. Review

Revue neurologique 2023

Restless legs syndrome. Other

Australian journal of … 2023

[Pharmacological Treatment for Restless Legs Syndrome]. Other

Brain and nerve … 2023

A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit? Other

Neurological research 2023

The incidence, complications, and treatment of iron deficiency in pregnancy. Review

European journal of … 2022 109 sitasi

Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review). Review

Experimental and therapeutic … 2022 60 sitasi

Brain-iron deficiency models of restless legs syndrome. Review

Experimental neurology 2022 36 sitasi

[Therapeutic approaches for sleep and rhythms disorders in children with ASD]. RCT

L'Encephale 2022 21 sitasi

Exploration of restless legs syndrome under the new concept: A review. Review

Medicine 2022 15 sitasi

Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging. Meta-Analysis

NeuroImage. Clinical 2022 14 sitasi

Treating Severe Refractory and Augmented Restless Legs Syndrome. Review

Chest 2022 14 sitasi

Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome. Other

Antioxidants (Basel, Switzerland) 2022 13 sitasi

Possible etiologies of restless legs syndrome in pregnancy: a narrative review. Review

Sleep science (Sao … 2022 12 sitasi

Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental … Review

Frontiers in psychiatry 2022 8 sitasi

Non-anemic iron deficiency: correlations between symptoms and iron status parameters. Other

European journal of … 2022 8 sitasi

Striatal mechanism of the restless legs syndrome. Other

Sleep 2022 4 sitasi

Does Dexmedetomidine Improve or Worsen Restless Leg Syndrome under Sedation: A Case Report and Extensive Review. Case Report

Case reports in … 2022 3 sitasi

Restless Leg Syndrome in Hemodialysis Patients: A Narrative Review. Review

The neurologist 2022 3 sitasi

[Restless legs syndrome and iron deficiency]. Review

MMW Fortschritte der … 2022 1 sitasi

Restless Legs Syndrome and the Eyes: Spectral-Domain Optic Coherence Tomography Study. Other

The neurologist 2022 1 sitasi

Restless legs syndrome. Review

Nature reviews. Disease … 2021 163 sitasi

Restless Legs Syndrome: Contemporary Diagnosis and Treatment. Review

Neurotherapeutics : the … 2021 162 sitasi

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. Review

Sleep medicine clinics 2021 14 sitasi

Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters. Other

Acta medica (Hradec … 2021 13 sitasi

Pharmacologic Treatment of Restless Legs Syndrome. Review

Current neuropharmacology 2021 13 sitasi

Restless Legs Syndrome - Clinical Features. Review

Sleep medicine clinics 2021 11 sitasi

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 sitasi

Pediatric Restless Legs Syndrome. Review

Sleep medicine clinics 2021 9 sitasi

Presynaptic inhibition in restless legs syndrome. Other

The International journal … 2021 6 sitasi

Restless Legs Syndrome: Challenges to Treatment. Review

Sleep medicine clinics 2021 5 sitasi

Diagnostic and Treatment Considerations in Restless Legs Syndrome Complicated by Diabetic Neuropathy. Review

Current diabetes reports 2021 5 sitasi

[Intravenous iron supplementation therapy Restless-Legs-Syndrome]. Other

Der Nervenarzt 2021

The role of iron repletion in adult iron deficiency anemia and other diseases. Review

European journal of … 2020 137 sitasi

Why Are Women Prone to Restless Legs Syndrome? Review

International journal of … 2020 34 sitasi

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid … RCT

Reumatismo 2020 21 sitasi

Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome. Review

Sleep medicine clinics 2020 18 sitasi

Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders. Review

Continuum (Minneapolis, Minn.) 2020 17 sitasi

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 sitasi

Unraveling the Mysteries of Restless Leg Syndrome. Review

Cureus 2020 5 sitasi

[Restless legs syndrome]. Review

La Revue de … 2020 3 sitasi

[Update on restless legs syndrome]. Other

Der Nervenarzt 2020 2 sitasi

Iodine and folate-essential for mothers to be. Other

The lancet. Diabetes … 2020 2 sitasi

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies. Review

Expert review of … 2019 123 sitasi

New Insights into the Neurobiology of Restless Legs Syndrome. Review

The Neuroscientist : … 2019 120 sitasi

Update on Restless Legs Syndrome: from Mechanisms to Treatment. Review

Current neurology and … 2019 68 sitasi

Iron for the treatment of restless legs syndrome. Meta-Analysis

The Cochrane database … 2019 62 sitasi

The neurophysiology of hyperarousal in restless legs syndrome: Hints for a role of glutamate/GABA. Review

Advances in pharmacology … 2019 61 sitasi

Neurochemical features of idiopathic restless legs syndrome. Review

Sleep medicine reviews 2019 47 sitasi

Iron supplementation for restless legs syndrome - A systematic review and meta-analysis. Meta-Analysis

European journal of … 2019 36 sitasi

Restless legs syndrome and iron deficiency in adults with attention-deficit/hyperactivity disorder. Other

Sleep 2019 33 sitasi

Treatment of pediatric restless legs syndrome. Review

Advances in pharmacology … 2019 27 sitasi

Iron uptake at the blood-brain barrier is influenced by sex and genotype. Review

Advances in pharmacology … 2019 20 sitasi

Drug Treatment of Restless Legs Syndrome in Older Adults. Review

Drugs & aging 2019 14 sitasi

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

Journal of clinical … 2019 13 sitasi

Advancing synthetic therapies for the treatment of restless legs syndrome. Review

Expert opinion on … 2019 12 sitasi

Caenorhabditis elegans and its applicability to studies on restless legs syndrome. Review

Advances in pharmacology … 2019 5 sitasi

Idiopathic restless legs syndrome treatment: Progress and pitfalls? Review

Advances in pharmacology … 2019 3 sitasi

D3 receptor agonist efficacy in restless legs syndrome. Review

Advances in pharmacology … 2019 2 sitasi

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an … Other

Sleep medicine 2018 259 sitasi

Comorbidities, treatment, and pathophysiology in restless legs syndrome. Case Report

The Lancet. Neurology 2018 202 sitasi

Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§. Review

Movement disorders : … 2018 145 sitasi

Management of treatment failure in restless legs syndrome (Willis-Ekbom disease). Review

Sleep medicine reviews 2018 40 sitasi

Human aniridia limbal epithelial cells lack expression of keratins K3 and K12. Other

Experimental eye research 2018 33 sitasi

Neuroimaging Applications in Restless Legs Syndrome. Review

International review of … 2018 24 sitasi

Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome. Review

Sleep medicine clinics 2018 21 sitasi

French consensus: Treatment of newly diagnosed restless legs syndrome. Review

Revue neurologique 2018 13 sitasi

French Consensus: How to diagnose restless legs syndrome. Review

Revue neurologique 2018 11 sitasi

Restless Legs Syndrome in Children. Review

Pediatric annals 2018 5 sitasi

Sleep Medicine: Restless Legs Syndrome. Other

Missouri medicine 2018

Evaluation and Treatment of Restless Legs Syndrome in the Primary Care Environment. Review

The Nursing clinics … 2018

Iron and restless legs syndrome: treatment, genetics and pathophysiology. Other

Sleep medicine 2017 118 sitasi

Brain imaging and networks in restless legs syndrome. Review

Sleep medicine 2017 95 sitasi

Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome. Review

Journal of neurology 2017 94 sitasi

Central and peripheral nervous system excitability in restless legs syndrome. Review

Sleep medicine 2017 92 sitasi

Restless Legs Syndrome: clinical features, diagnosis and a practical approach to management. Review

Practical neurology 2017 69 sitasi

Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters. Other

Scientific reports 2017 66 sitasi

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

Journal of renal … 2017 26 sitasi

Should oral iron be first-line therapy for pediatric restless legs syndrome and periodic limb movement disorder? Other

Sleep medicine 2017 16 sitasi

Sleep Disorders: Restless Legs Syndrome. Review

FP essentials 2017 11 sitasi

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women. Other

The journal of … 2017 8 sitasi

Bupropion and Iron for Restless Leg Syndrome: Do They Have Efficacy Similar to Ropinirole? Other

Annals of Indian … 2017 1 sitasi

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force … Other

Sleep medicine 2016 280 sitasi

Restless legs syndrome associated with major diseases: A systematic review and new concept. Systematic Review

Neurology 2016 210 sitasi

Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Review

Acta neurologica Scandinavica 2016 104 sitasi

Restless legs syndrome. Review

Clinical medicine (London, … 2016 44 sitasi

Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital. Other

Nephro-urology monthly 2016 21 sitasi

Culture and characterization of rat hair follicle stem cells. Other

Cytotechnology 2016 18 sitasi

Importance of donor history of restless leg syndrome and pica to asses iron deficiency. Other

Transfusion and apheresis … 2016 10 sitasi

Restless Leg Syndrome/Willis-Ekbom disease in women with iron deficiency anemia. Other

Ideggyogyaszati szemle 2016 6 sitasi

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 sitasi

Predictive factors of restless leg syndrome in hemodialysis patients. Other

Journal of renal … 2016 2 sitasi

[Iron deficiency, Fatigue and Restless-Legs-Syndrome]. Review

Wiener medizinische Wochenschrift … 2016 2 sitasi

Asthma as a disruption in iron homeostasis. Review

Biometals : an … 2016

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Review

Sleep medicine clinics 2015 158 sitasi

Restless legs syndrome: clinical presentation diagnosis and treatment. Review

Sleep medicine 2015 72 sitasi

Restless legs syndrome in multiple sclerosis. Review

Sleep medicine reviews 2015 38 sitasi

Restless Legs Syndrome/Willis-Ekbom Disease and Growing Pains in Children and Adolescents. Review

Sleep medicine clinics 2015 29 sitasi

Neuroimaging in Restless Legs Syndrome. Review

Sleep medicine clinics 2015 29 sitasi

Restless legs syndrome. Review

Critical care clinics 2015 28 sitasi

Differential Diagnoses of Restless Legs Syndrome/Willis-Ekbom Disease: Mimics and Comorbidities. Review

Sleep medicine clinics 2015 28 sitasi

Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Other

Sleep & breathing … 2015 22 sitasi

[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)]. Review

Nihon rinsho. Japanese … 2015

[RESTLESS LEGS SYNDROME--WILLIS-EKBOM DISEASE]. Other

La Revue du … 2015

Therapeutic advances in restless legs syndrome (RLS). Meta-Analysis

Movement disorders : … 2015

Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease). Review

Sleep medicine 2014 281 sitasi

Restless legs syndrome and pregnancy: a review. Review

Parkinsonism & related … 2014 78 sitasi

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease). Other

Sleep medicine 2014 58 sitasi

Disorders of heavy metals. Review

Handbook of clinical … 2014 52 sitasi

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 sitasi

The association of Restless Legs Syndrome with hypertension and cardiovascular disease. Review

Medical science monitor … 2014 18 sitasi

Latest guidelines and advances for treatment of restless legs syndrome. Review

The Journal of … 2014 12 sitasi

New treatment options for the management of restless leg syndrome. Review

The Journal of … 2014 7 sitasi

Treatment of pediatric restless legs syndrome. Other

Clinical pediatrics 2014

Restless legs syndrome, pica, and iron status in blood donors. Other

Transfusion 2013 64 sitasi

Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine … Other

Kidney & blood … 2013 43 sitasi

Migraine and restless leg syndrome co-morbidity may be due to iron deficiency. Other

Annals of Indian … 2013 6 sitasi

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 sitasi

Iron for restless legs syndrome. Meta-Analysis

The Cochrane database … 2012 31 sitasi

ADMET considerations for restless leg syndrome drug treatments. Review

Expert opinion on … 2012 6 sitasi

Nocturnal leg cramps. Review

American family physician 2012

Iron deficiency: beyond anemia. Review

Indian journal of … 2011 75 sitasi

Restless legs syndrome. Review

Handbook of clinical … 2011 8 sitasi

Restless legs syndrome: pathophysiology, clinical presentation and management. Review

Nature reviews. Neurology 2010 293 sitasi

Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment. Review

Sleep medicine 2010 115 sitasi

Finding a safe and effective intravenous iron treatment for restless legs syndrome. Other

Sleep medicine 2010

Update in restless legs syndrome. Review

Current opinion in … 2010

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis. Review

Clinics (Sao Paulo, … 2010

Restless legs syndrome. Review

Journal of internal … 2009 125 sitasi

Biodiversity of thermophilic prokaryotes with hydrolytic activities in hot springs of Uzon Caldera, Kamchatka (Russia). Other

Applied and environmental … 2009 105 sitasi

L-methioninase production by Aspergillus flavipes under solid-state fermentation. Other

Journal of basic … 2009 54 sitasi

Restless legs syndrome: differential diagnosis and management with pramipexole. Review

Clinical interventions in … 2009

[Secondary restless legs syndrome]. Review

Brain and nerve … 2009

Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Review

Sleep 2009

Diagnosis and management of restless legs syndrome in children. Review

Sleep medicine reviews 2009

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Review

Movement disorders : … 2008 309 sitasi

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 sitasi

[Restless legs syndrome]. Review

Acta medica portuguesa 2008

Restless legs syndrome. Other

American family physician 2008

Restless legs syndrome: pathophysiology, diagnosis and treatment. Review

CNS drugs 2008

Pathophysiology of restless legs syndrome: evidence for iron involvement. Review

Current neurology and … 2008

An update on the pathophysiology and genetics of restless legs syndrome. Review

Current neurology and … 2008

Restless leg syndrome: iron important. Case Report

The Nurse practitioner 2008

Nonhematological benefits of iron. Review

American journal of … 2007 61 sitasi

Update of the pathophysiology of the restless-legs-syndrome. Review

Movement disorders : … 2007

Animal models of restless legs syndrome. Review

Sleep medicine 2007

Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome. Review

The American journal … 2007

Restless legs syndrome: demographics, presentation, and differential diagnosis. Review

Geriatrics 2007

Is iron deficiency an underlying cause of pediatric restless legs syndrome and of attention-deficit/hyperactivity disorder? Other

Sleep medicine 2007

Restless legs syndrome: pathophysiology and the role of iron and folate. Review

Alternative medicine review … 2007

Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. Other

Sleep medicine 2007

Epithelial regeneration from bioengineered skin explants in culture. Other

The British journal … 2006 29 sitasi

Restless legs syndrome. Review

American journal of … 2006 23 sitasi

Iron and restless legs syndrome: the story unfolds. Other

Sleep medicine 2006 8 sitasi

Is restless legs syndrome underrecognized? Current management. Review

Joint bone spine 2006

The restless legs syndrome. Review

The Lancet. Neurology 2005 215 sitasi

The restless legs syndrome. Review

Progress in neurobiology 2005 47 sitasi

Restless legs syndrome. Review

Current neurology and … 2005 15 sitasi

Restless legs syndrome. Review

Neurologic clinics 2005 13 sitasi

Role of medications in the etiology and treatment of restless leg syndrome. Other

Home healthcare nurse 2005 3 sitasi

Restless legs syndrome. Review

Primary care 2005 2 sitasi

Restless legs syndrome. Review

Current opinion in … 2005

Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Review

Sleep medicine 2004 392 sitasi

Restless legs syndrome and pregnancy. Other

Neurology 2004 386 sitasi

Childhood-onset restless legs syndrome. Other

Annals of neurology 2004 183 sitasi

[Restless legs syndrome and periodic limb movements during sleep in a patient with obstructive sleep apnea]. Other

Neurologia i neurochirurgia … 2004 2 sitasi

Epidemiology and clinical findings of restless legs syndrome. Review

Sleep medicine 2004

P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Other

American journal of … 2004

Restless legs syndrome and PD: a review of the evidence for a possible association. Review

Neurology 2003

Treating restless legs syndrome: current pathophysiological concepts and clinical trials. Review

Expert opinion on … 2002

Restless legs syndrome in the older adult: diagnosis and management. Review

Drugs & aging 2002

The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating … Other

Medical hypotheses 2002

Iron, brain and restless legs syndrome. Other

Sleep medicine reviews 2001 48 sitasi

Restless legs syndrome. Review

The Journal of … 2001 7 sitasi

Restless legs syndrome: a review of clinical and pathophysiologic features. Review

Journal of clinical … 2001

Insight into the pathophysiology of restless legs syndrome. Review

Journal of neuroscience … 2000

Secondary periodic limb movement disorder and restless legs syndrome. Other

Sleep medicine reviews 1999 31 sitasi

How to help patients with restless legs syndrome. Discerning the indescribable and relaxing the restless. Review

Postgraduate medicine 1999

Iron and the restless legs syndrome. Other

Sleep 1998

Restless legs syndrome. Review

Mayo Clinic proceedings 1997 30 sitasi

Carcinosarcoma of the skin. Case report and literature review. Case Report

The American Journal … 1996 1 sitasi

Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes. Other

Electrophoresis 1995 57 sitasi

Restless legs syndrome and periodic movements of sleep. Review

Mayo Clinic proceedings 1990 68 sitasi

The restless leg syndrome. Other

Canadian Medical Association … 1967

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

rls:: 65 mg elemental iron if ferritin <75
general:: 18 mg/day (women)

Batas atas: 45 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
various	--	Positive	--
None	--	Positive	90
1000 mg ferric carboxymaltose	--	Positive	58
iron supplementation, folate, dopamine agonists (non-pharmacological and pharmacological)	--	Positive	--
dopamine agonists, iron supplementation, alpha-2-delta ligands	--	Positive	--
None	--	Neutral	--
None	--	Mixed	--
None	--	Positive	--

Waktu terbaik diminum: On an empty stomach with vitamin C; take in the morning, not before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Constipation
⚠ Nausea
⚠ Stomach pain
⚠ Dark stools
⚠ Iron overload risk (hemochromatosis)

Interaksi yang Diketahui

● Antacids and PPIs — reduce iron absorption
● Levothyroxine — iron reduces thyroid medication absorption
● Antibiotics (tetracyclines, fluoroquinolones) — mutual absorption reduction
● Calcium supplements — take separately by 2 hours

Asupan atas yang dapat ditoleransi: 45 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Zat Besi help with Sindrom Kaki Gelisah?

Based on 173 studies with 36,638 participants, there is strong evidence from multiple clinical trials that Zat Besi may support Sindrom Kaki Gelisah management. Our evidence grade is A (Strong Evidence).

How much Zat Besi should I take for Sindrom Kaki Gelisah?

Studies have used various dosages. A commonly studied range is 65 mg elemental iron if ferritin <75. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zat Besi?

Reported side effects may include Constipation, Nausea, Stomach pain, Dark stools. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zat Besi and Sindrom Kaki Gelisah?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 173 peer-reviewed studies with 36,638 total participants. The overall direction of effect is mixed.

Related Evidence

Bahan lain untuk Sindrom Kaki Gelisah

Magnesium Glycinate F

Kesimpulan Singkat

Berdasarkan 65 studi (5 meta-analyses) dengan 24,923 peserta secara total. 34/65 studi menunjukkan efek positif.

Evidence Strength92%

High confidence

Rincian Studi

RCT (3)Meta (9)Other (161)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Sindrom Kaki Gelisah

Pelajari Lebih Lanjut

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