Kava для Бессонница
A Доказательства Несколько крупных клинических испытаний стабильно демонстрируют значительные преимущества.Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.
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A
Итог
Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.
Key Study Findings
Case Reports
n=1
6 weeks
Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.
Dose: None
или: None
Outcome: acute kava dermopathy with sebaceous gland necrosis
Эффект: None
None
Популяция: 41-year-old Australian woman consuming kava for anxiety and insomnia
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
или: Placebo
Эффект: None
None
Case Reports
n=1
Open-label
Severe kava withdrawal managed with phenobarbital.
Dose: None
или: None
Outcome: Resolution of kava withdrawal symptoms
Эффект: None
None
Популяция: 45-year-old man with kava and kratom withdrawal
narrative review
Herbal and Natural Supplements for Improving Sleep: A Literature Review.
Dose: varies by supplement
или: Placebo
Эффект: None
None
Other
Double-blind
The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …
Dose: AB-free kava extract
или: Placebo
Outcome: Tobacco cessation via stress/insomnia management
Эффект: None
None
Популяция: Adult smokers (trial protocol)
systematic review
n=17
Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and …
Dose: various
или: Placebo
Эффект: None
None
Key Statistics
34
Исследования
4679
Участники
↔
Mixed
A
Оценка
Referenced Papers
The Medical journal …
2026
Naunyn-Schmiedeberg's archives of …
2025
4 цитирований
The American journal …
2025
1 цитирований
Psychiatry investigation
2024
24 цитирований
BMC complementary medicine …
2024
1 цитирований
Frontiers in public …
2023
13 цитирований
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Meta-Analysis
Pharmacological research
2022
51 цитирований
Journal of clinical …
2022
27 цитирований
Cureus
2022
17 цитирований
Natural product research
2022
3 цитирований
Journal of psychosocial …
2022
2 цитирований
Combinatorial chemistry & …
2021
16 цитирований
Journal of clinical …
2020
17 цитирований
Chemical research in …
2019
6 цитирований
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 цитирований
Natural Products from Single Plants as Sleep Aids: A Systematic Review.
Systematic Review
Journal of medicinal …
2018
19 цитирований
Sleep medicine reviews
2015
152 цитирований
Holistic nursing practice
2014
10 цитирований
Toxicokinetics of kava.
Other
Advances in pharmacological …
2011
79 цитирований
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
Systematic Review
Nutrition journal
2010
187 цитирований
FASEB journal : …
2010
110 цитирований
Medical science monitor …
2009
85 цитирований
Journal of psychopharmacology …
2005
176 цитирований
Medicine
2005
128 цитирований
Psychopharmacology
2005
36 цитирований
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 цитирований
Human psychopharmacology
2003
45 цитирований
Primary care
2002
43 цитирований
Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents.
Review
General hospital psychiatry
2002
38 цитирований
Phytotherapy research : …
2001
74 цитирований
Human psychopharmacology
2001
52 цитирований
Journal of psychiatric …
2001
42 цитирований
Psychosomatic medicine
1999
136 цитирований
[Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract].
Case Report
Der Hautarzt; Zeitschrift …
1996
22 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- sleep:
- 120-250 mg kavalactones/day, 1-2 hrs before bed
Верхний предел: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | 6 weeks | Negative | 1 |
| None | -- | Positive | -- |
| None | -- | Positive | 1 |
| varies by supplement | -- | Positive | -- |
| AB-free kava extract | -- | Mixed | -- |
| various | -- | Mixed | 17 |
| None | -- | Mixed | -- |
| Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion | -- | Positive | -- |
Лучшее время приёма: 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Drowsiness and reduced coordination
- ⚠ Hepatotoxicity (rare but serious — consult healthcare provider)
- ⚠ Skin rash (kava dermopathy) with chronic high-dose use
- ⚠ GI discomfort
Известные взаимодействия
- ● Alcohol — increased hepatotoxicity risk and CNS depression
- ● Hepatotoxic medications (acetaminophen, statins) — additive liver stress
- ● Benzodiazepines and sedatives — additive CNS depression
- ● CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
- ● Levodopa and dopaminergic drugs — kava may reduce efficacy
Допустимый верхний уровень потребления: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Kava help with Бессонница?
Based on 34 studies with 4,679 participants, there is strong evidence from multiple clinical trials that Kava may support Бессонница management. Our evidence grade is A (Strong Evidence).
How much Kava should I take for Бессонница?
Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Kava?
Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Kava and Бессонница?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 4,679 total participants. The overall direction of effect is mixed.
Related Evidence
Другие ингредиенты для Бессонница
Kava для других состояний
References
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- [3] William Bleifuss et al.. Am J Emerg Med. 2025. Severe kava withdrawal managed with phenobarbital. doi:10.1016/j.ajem.2025.06.016 PubMed
- [4] Ji Won Yeom et al.. Psychiatry Investig. 2024. Herbal and Natural Supplements for Improving Sleep: A Literature Review. doi:10.30773/pi.2024.0121 PubMed
- [5] Chengguo Xing et al.. BMC Complement Med Ther. 2024. The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a … doi:10.1186/s12906-024-04722-9 PubMed
- [6] Fei-Yi Zhao et al.. Front Public Health. 2023. Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and critical assessment of comprehensive clinical … doi:10.3389/fpubh.2023.1157419 PubMed
- [7] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
- [8] Rita B Soares et al.. J Clin Med. 2022. An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. doi:10.3390/jcm11144039 PubMed
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- [21] Ping Zhou et al.. FASEB J. 2010. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. doi:10.1096/fj.10-163311 PubMed
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- [32] David Wheatley. Hum Psychopharmacol. 2001. Stress-induced insomnia treated with kava and valerian: singly and in combination. doi:10.1002/hup.299 PubMed
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