Kava ：不眠症

Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.

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結論

Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.

Key Study Findings

Case Reports n=1 6 weeks

Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.

Dose: None vs: None Outcome: acute kava dermopathy with sebaceous gland necrosis 効果: None None

対象集団: 41-year-old Australian woman consuming kava for anxiety and insomnia

Review

Integrative sleep management: from molecular pathways to conventional and herbal treatments.

Dose: None vs: Placebo 効果: None None

Case Reports n=1 Open-label

Severe kava withdrawal managed with phenobarbital.

Dose: None vs: None Outcome: Resolution of kava withdrawal symptoms 効果: None None

対象集団: 45-year-old man with kava and kratom withdrawal

narrative review

Herbal and Natural Supplements for Improving Sleep: A Literature Review.

Dose: varies by supplement vs: Placebo 効果: None None

Other Double-blind

The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …

Dose: AB-free kava extract vs: Placebo Outcome: Tobacco cessation via stress/insomnia management 効果: None None

対象集団: Adult smokers (trial protocol)

systematic review n=17

Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and …

Dose: various vs: Placebo 効果: None None

Key Statistics

研究数

4679

参加者数

↔

Mixed

グレード

Referenced Papers

Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption. Case Report

The Medical journal … 2026

Integrative sleep management: from molecular pathways to conventional and herbal treatments. Review

Naunyn-Schmiedeberg's archives of … 2025 4 件の引用

Severe kava withdrawal managed with phenobarbital. Case Report

The American journal … 2025 1 件の引用

Herbal and Natural Supplements for Improving Sleep: A Literature Review. Other

Psychiatry investigation 2024 24 件の引用

The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a … Other

BMC complementary medicine … 2024 1 件の引用

Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and critical assessment of comprehensive clinical … Systematic Review

Frontiers in public … 2023 13 件の引用

Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Meta-Analysis

Pharmacological research 2022 51 件の引用

An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. Review

Journal of clinical … 2022 27 件の引用

The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. Review

Cureus 2022 17 件の引用

Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain. Other

Natural product research 2022 3 件の引用

Calm Down With Kava: What Clinicians Need to Know. Other

Journal of psychosocial … 2022 2 件の引用

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 件の引用

The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … Other

Journal of clinical … 2020 17 件の引用

Enzymes and Pathways of Kavain Bioactivation and Biotransformation. Other

Chemical research in … 2019 6 件の引用

GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Systematic Review

Phytotherapy research : … 2018 95 件の引用

Natural Products from Single Plants as Sleep Aids: A Systematic Review. Systematic Review

Journal of medicinal … 2018 19 件の引用

Herbal medicine for insomnia: A systematic review and meta-analysis. Meta-Analysis

Sleep medicine reviews 2015 152 件の引用

Psychophytomedicine: an overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. Review

Holistic nursing practice 2014 10 件の引用

Toxicokinetics of kava. Other

Advances in pharmacological … 2011 79 件の引用

Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Systematic Review

Nutrition journal 2010 187 件の引用

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. Other

FASEB journal : … 2010 110 件の引用

Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Review

Medical science monitor … 2009 85 件の引用

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 件の引用

An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. RCT

Medicine 2005 128 件の引用

Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. Other

Psychopharmacology 2005 36 件の引用

Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. Review

Journal of clinical … 2005

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 件の引用

Saccade and cognitive impairment associated with kava intoxication. Other

Human psychopharmacology 2003 45 件の引用

Anxiety, depression, and insomnia. Review

Primary care 2002 43 件の引用

Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. Review

General hospital psychiatry 2002 38 件の引用

Kava and valerian in the treatment of stress-induced insomnia. Other

Phytotherapy research : … 2001 74 件の引用

Stress-induced insomnia treated with kava and valerian: singly and in combination. Other

Human psychopharmacology 2001 52 件の引用

Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. Other

Journal of psychiatric … 2001 42 件の引用

Dietary supplements and natural products as psychotherapeutic agents. Review

Psychosomatic medicine 1999 136 件の引用

[Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract]. Case Report

Der Hautarzt; Zeitschrift … 1996 22 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

sleep:: 120-250 mg kavalactones/day, 1-2 hrs before bed

上限量： 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

研究で検討された用量

用量	期間	効果	N
None	6 weeks	Negative	1
None	--	Positive	--
None	--	Positive	1
varies by supplement	--	Positive	--
AB-free kava extract	--	Mixed	--
various	--	Mixed	17
None	--	Mixed	--
Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion	--	Positive	--

推奨摂取タイミング： 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision

Safety & Side Effects

報告されている副作用

⚠ Drowsiness and reduced coordination
⚠ Hepatotoxicity (rare but serious — consult healthcare provider)
⚠ Skin rash (kava dermopathy) with chronic high-dose use
⚠ GI discomfort

既知の相互作用

● Alcohol — increased hepatotoxicity risk and CNS depression
● Hepatotoxic medications (acetaminophen, statins) — additive liver stress
● Benzodiazepines and sedatives — additive CNS depression
● CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
● Levodopa and dopaminergic drugs — kava may reduce efficacy

耐容上限摂取量： 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Kava help with 不眠症?

Based on 34 studies with 4,679 participants, there is strong evidence from multiple clinical trials that Kava may support 不眠症 management. Our evidence grade is A (Strong Evidence).

How much Kava should I take for 不眠症?

Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Kava?

Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Kava and 不眠症?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 4,679 total participants. The overall direction of effect is mixed.

Related Evidence

に関する他の成分：不眠症

メラトニン A バレリアンルート A CBD A オメガ3脂肪酸 A トリプトファン A ビタミンD A

Kava 他の症状・状態について

不安に伴う睡眠障害 A Hyperarousal and Cognitive Insomnia A

総合評価

Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.

Evidence Strength92%

High confidence

研究の内訳

RCT (1)Meta (2)Other (31)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：不眠症

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Kava ： 不眠症

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： 不眠症

Kava 他の症状・状態について

Kava ：不眠症

に関する他の成分：不眠症