Kava para Insônia
A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.
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A
Conclusão
Based on 34 studies (8 meta-analyses, 1 RCT) with 4,679 total participants. Results are mixed across studies.
Key Study Findings
Case Reports
n=1
6 weeks
Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.
Dose: None
vs: None
Outcome: acute kava dermopathy with sebaceous gland necrosis
Efeito: None
None
População: 41-year-old Australian woman consuming kava for anxiety and insomnia
Review
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Dose: None
vs: Placebo
Efeito: None
None
Case Reports
n=1
Open-label
Severe kava withdrawal managed with phenobarbital.
Dose: None
vs: None
Outcome: Resolution of kava withdrawal symptoms
Efeito: None
None
População: 45-year-old man with kava and kratom withdrawal
narrative review
Herbal and Natural Supplements for Improving Sleep: A Literature Review.
Dose: varies by supplement
vs: Placebo
Efeito: None
None
Other
Double-blind
The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …
Dose: AB-free kava extract
vs: Placebo
Outcome: Tobacco cessation via stress/insomnia management
Efeito: None
None
População: Adult smokers (trial protocol)
systematic review
n=17
Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and …
Dose: various
vs: Placebo
Efeito: None
None
Key Statistics
34
Estudos
4679
Participantes
↔
Mixed
A
Nota
Referenced Papers
The Medical journal …
2026
Naunyn-Schmiedeberg's archives of …
2025
4 citações
The American journal …
2025
1 citações
Psychiatry investigation
2024
24 citações
BMC complementary medicine …
2024
1 citações
Frontiers in public …
2023
13 citações
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
Meta-Analysis
Pharmacological research
2022
51 citações
Journal of clinical …
2022
27 citações
Cureus
2022
17 citações
Natural product research
2022
3 citações
Journal of psychosocial …
2022
2 citações
Combinatorial chemistry & …
2021
16 citações
Journal of clinical …
2020
17 citações
Chemical research in …
2019
6 citações
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
Systematic Review
Phytotherapy research : …
2018
95 citações
Natural Products from Single Plants as Sleep Aids: A Systematic Review.
Systematic Review
Journal of medicinal …
2018
19 citações
Sleep medicine reviews
2015
152 citações
Holistic nursing practice
2014
10 citações
Toxicokinetics of kava.
Other
Advances in pharmacological …
2011
79 citações
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
Systematic Review
Nutrition journal
2010
187 citações
FASEB journal : …
2010
110 citações
Medical science monitor …
2009
85 citações
Journal of psychopharmacology …
2005
176 citações
Medicine
2005
128 citações
Psychopharmacology
2005
36 citações
Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Review
Journal of clinical …
2005
Integrative cancer therapies
2004
59 citações
Human psychopharmacology
2003
45 citações
Primary care
2002
43 citações
Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents.
Review
General hospital psychiatry
2002
38 citações
Phytotherapy research : …
2001
74 citações
Human psychopharmacology
2001
52 citações
Journal of psychiatric …
2001
42 citações
Psychosomatic medicine
1999
136 citações
[Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract].
Case Report
Der Hautarzt; Zeitschrift …
1996
22 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- sleep:
- 120-250 mg kavalactones/day, 1-2 hrs before bed
Limite superior: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | 6 weeks | Negative | 1 |
| None | -- | Positive | -- |
| None | -- | Positive | 1 |
| varies by supplement | -- | Positive | -- |
| AB-free kava extract | -- | Mixed | -- |
| various | -- | Mixed | 17 |
| None | -- | Mixed | -- |
| Various medicinal herbs: Silexan, Kava, Ginkgo biloba, Withania somnifera, Galphimia glauca, Passion | -- | Positive | -- |
Melhor horário: 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Drowsiness and reduced coordination
- ⚠ Hepatotoxicity (rare but serious — consult healthcare provider)
- ⚠ Skin rash (kava dermopathy) with chronic high-dose use
- ⚠ GI discomfort
Interações Conhecidas
- ● Alcohol — increased hepatotoxicity risk and CNS depression
- ● Hepatotoxic medications (acetaminophen, statins) — additive liver stress
- ● Benzodiazepines and sedatives — additive CNS depression
- ● CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
- ● Levodopa and dopaminergic drugs — kava may reduce efficacy
Ingestão máxima tolerável: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Kava help with Insônia?
Based on 34 studies with 4,679 participants, there is strong evidence from multiple clinical trials that Kava may support Insônia management. Our evidence grade is A (Strong Evidence).
How much Kava should I take for Insônia?
Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Kava?
Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Kava and Insônia?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 4,679 total participants. The overall direction of effect is mixed.
Related Evidence
Outros ingredientes para Insônia
Kava para outras condições
References
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- [3] William Bleifuss et al.. Am J Emerg Med. 2025. Severe kava withdrawal managed with phenobarbital. doi:10.1016/j.ajem.2025.06.016 PubMed
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- [5] Chengguo Xing et al.. BMC Complement Med Ther. 2024. The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a … doi:10.1186/s12906-024-04722-9 PubMed
- [6] Fei-Yi Zhao et al.. Front Public Health. 2023. Identifying complementary and alternative medicine recommendations for insomnia treatment and care: a systematic review and critical assessment of comprehensive clinical … doi:10.3389/fpubh.2023.1157419 PubMed
- [7] Wenting Zhang et al.. Pharmacol Res. 2022. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. doi:10.1016/j.phrs.2022.106204 PubMed
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- [29] Michele M Larzelere et al.. Prim Care. 2002. Anxiety, depression, and insomnia. doi:10.1016/s0095-4543(01)00003-3 PubMed
- [30] Ka Fai Chung et al.. Gen Hosp Psychiatry. 2002. Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. doi:10.1016/s0163-8343(02)00210-4 PubMed
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- [32] David Wheatley. Hum Psychopharmacol. 2001. Stress-induced insomnia treated with kava and valerian: singly and in combination. doi:10.1002/hup.299 PubMed
- [33] R P Brown et al.. J Psychiatr Pract. 2001. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. doi:10.1097/00131746-200103000-00002 PubMed
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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.