Kava para Hyperarousal and Cognitive Insomnia

Based on 23 studies (4 meta-analyses, 1 RCT) with 2,043 total participants. Results are mixed across studies.

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Conclusão

Based on 23 studies (4 meta-analyses, 1 RCT) with 2,043 total participants. Results are mixed across studies.

Key Study Findings

Case Reports n=1 6 weeks

Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.

Dose: None vs: None Outcome: acute kava dermopathy with sebaceous gland necrosis Efeito: None None

População: 41-year-old Australian woman consuming kava for anxiety and insomnia

Case Reports n=1 Open-label

Severe kava withdrawal managed with phenobarbital.

Dose: None vs: None Outcome: Resolution of kava withdrawal symptoms Efeito: None None

População: 45-year-old man with kava and kratom withdrawal

Other Double-blind

The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …

Dose: AB-free kava extract vs: Placebo Outcome: Tobacco cessation via stress/insomnia management Efeito: None None

População: Adult smokers (trial protocol)

Controlled Clinical Trial

Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain.

Dose: None vs: Vehicle control Outcome: Acute oral toxicity, antinociceptive activity Efeito: None None

População: Animal model

Systematic Review

The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review.

Dose: None vs: None Outcome: Sleep quality improvement Efeito: None None

População: Insomnia patients

Review

Calm Down With Kava: What Clinicians Need to Know.

Dose: None vs: None Outcome: None Efeito: None None

População: Kava users

Key Statistics

Estudos

2043

Participantes

↔

Mixed

Nota

Referenced Papers

Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption. Case Report

The Medical journal … 2026

Severe kava withdrawal managed with phenobarbital. Case Report

The American journal … 2025 1 citações

The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a … Other

BMC complementary medicine … 2024 1 citações

An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. Review

Journal of clinical … 2022 27 citações

The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. Review

Cureus 2022 17 citações

Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain. Other

Natural product research 2022 3 citações

Calm Down With Kava: What Clinicians Need to Know. Other

Journal of psychosocial … 2022 2 citações

Nutraceuticals for Sleep Disorders. Review

Combinatorial chemistry & … 2021 16 citações

The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … Other

Journal of clinical … 2020 17 citações

Enzymes and Pathways of Kavain Bioactivation and Biotransformation. Other

Chemical research in … 2019 6 citações

Natural Products from Single Plants as Sleep Aids: A Systematic Review. Systematic Review

Journal of medicinal … 2018 19 citações

Herbal medicine for insomnia: A systematic review and meta-analysis. Meta-Analysis

Sleep medicine reviews 2015 152 citações

Psychophytomedicine: an overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. Review

Holistic nursing practice 2014 10 citações

Toxicokinetics of kava. Other

Advances in pharmacological … 2011 79 citações

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. Other

FASEB journal : … 2010 110 citações

Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Review

Journal of psychopharmacology … 2005 176 citações

An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. RCT

Medicine 2005 128 citações

Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. Other

Psychopharmacology 2005 36 citações

Safety and efficacy of herbal sedatives in cancer care. Review

Integrative cancer therapies 2004 59 citações

Saccade and cognitive impairment associated with kava intoxication. Other

Human psychopharmacology 2003 45 citações

Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. Review

General hospital psychiatry 2002 38 citações

Kava and valerian in the treatment of stress-induced insomnia. Other

Phytotherapy research : … 2001 74 citações

Stress-induced insomnia treated with kava and valerian: singly and in combination. Other

Human psychopharmacology 2001 52 citações

[Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract]. Case Report

Der Hautarzt; Zeitschrift … 1996 22 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:: 120-250 mg kavalactones/day, 1-2 hrs before bed

Limite superior: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	6 weeks	Negative	1
None	--	Positive	1
AB-free kava extract	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
not specified	--	Positive	--

Melhor horário: 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Drowsiness and reduced coordination
⚠ Hepatotoxicity (rare but serious — consult healthcare provider)
⚠ Skin rash (kava dermopathy) with chronic high-dose use
⚠ GI discomfort

Interações Conhecidas

● Alcohol — increased hepatotoxicity risk and CNS depression
● Hepatotoxic medications (acetaminophen, statins) — additive liver stress
● Benzodiazepines and sedatives — additive CNS depression
● CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
● Levodopa and dopaminergic drugs — kava may reduce efficacy

Ingestão máxima tolerável: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Kava help with Hyperarousal and Cognitive Insomnia?

Based on 23 studies with 2,043 participants, there is strong evidence from multiple clinical trials that Kava may support Hyperarousal and Cognitive Insomnia management. Our evidence grade is A (Strong Evidence).

How much Kava should I take for Hyperarousal and Cognitive Insomnia?

Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Kava?

Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Kava and Hyperarousal and Cognitive Insomnia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 23 peer-reviewed studies with 2,043 total participants. The overall direction of effect is mixed.

Related Evidence

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Kava para outras condições

Insônia A Problemas de Sono Relacionados à Ansiedade A

Veredito Rápido

Based on 23 studies (4 meta-analyses, 1 RCT) with 2,043 total participants. Results are mixed across studies.

Evidence Strength92%

High confidence

Detalhamento dos Estudos

RCT (1)Meta (1)Other (21)

Comparar Alternativas

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Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.