카바 관련 과각성 및 인지적 불면증
A 근거 여러 대규모 임상 시험이 일관되게 유의미한 효과를 보여줍니다.카바의 GABA성 및 도파민성 활성은 이 불면증 아형을 특징짓는 인지적 및 생리적 과각성을 줄이는 데 도움이 될 수 있습니다. 과각성 관련 결과에 대한 직접적 근거는 제한적이지만, 항불안 데이터는 이를 뒷받침합니다. 간독성 위험으로 신중한 의료 감독이 필요합니다.
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A
결론
카바의 GABA성 및 도파민성 활성은 이 불면증 아형을 특징짓는 인지적 및 생리적 과각성을 줄이는 데 도움이 될 수 있습니다. 과각성 관련 결과에 대한 직접적 근거는 제한적이지만, 항불안 데이터는 이를 뒷받침합니다. 간독성 위험으로 신중한 의료 감독이 필요합니다.
Key Study Findings
Case Reports
n=1
6 weeks
Diagnosing Acute Kava Dermopathy: A Case Report of a Characteristic Cutaneous Eruption.
Dose: None
vs: None
Outcome: acute kava dermopathy with sebaceous gland necrosis
효과: None
None
대상 집단: 41-year-old Australian woman consuming kava for anxiety and insomnia
Case Reports
n=1
Open-label
Severe kava withdrawal managed with phenobarbital.
Dose: None
vs: None
Outcome: Resolution of kava withdrawal symptoms
효과: None
None
대상 집단: 45-year-old man with kava and kratom withdrawal
Other
Double-blind
The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and …
Dose: AB-free kava extract
vs: Placebo
Outcome: Tobacco cessation via stress/insomnia management
효과: None
None
대상 집단: Adult smokers (trial protocol)
Controlled Clinical Trial
Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain.
Dose: None
vs: Vehicle control
Outcome: Acute oral toxicity, antinociceptive activity
효과: None
None
대상 집단: Animal model
Systematic Review
The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review.
Dose: None
vs: None
Outcome: Sleep quality improvement
효과: None
None
대상 집단: Insomnia patients
Review
Calm Down With Kava: What Clinicians Need to Know.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Kava users
Key Statistics
23
연구
2043
참여자
↔
Mixed
A
등급
Referenced Papers
The Medical journal …
2026
The American journal …
2025
1 인용
BMC complementary medicine …
2024
1 인용
Journal of clinical …
2022
27 인용
Cureus
2022
17 인용
Natural product research
2022
3 인용
Journal of psychosocial …
2022
2 인용
Combinatorial chemistry & …
2021
16 인용
Journal of clinical …
2020
17 인용
Chemical research in …
2019
6 인용
Natural Products from Single Plants as Sleep Aids: A Systematic Review.
Systematic Review
Journal of medicinal …
2018
19 인용
Sleep medicine reviews
2015
152 인용
Holistic nursing practice
2014
10 인용
Toxicokinetics of kava.
Other
Advances in pharmacological …
2011
79 인용
FASEB journal : …
2010
110 인용
Journal of psychopharmacology …
2005
176 인용
Medicine
2005
128 인용
Psychopharmacology
2005
36 인용
Integrative cancer therapies
2004
59 인용
Human psychopharmacology
2003
45 인용
Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents.
Review
General hospital psychiatry
2002
38 인용
Phytotherapy research : …
2001
74 인용
Human psychopharmacology
2001
52 인용
[Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract].
Case Report
Der Hautarzt; Zeitschrift …
1996
22 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- sleep:
- 120-250 mg kavalactones/day, 1-2 hrs before bed
상한량: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | 6 weeks | Negative | 1 |
| None | -- | Positive | 1 |
| AB-free kava extract | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| not specified | -- | Positive | -- |
권장 복용 시간: 1-2 hours before bed; avoid daily use beyond 3 months without medical supervision
Safety & Side Effects
보고된 부작용
- ⚠ Drowsiness and reduced coordination
- ⚠ Hepatotoxicity (rare but serious — consult healthcare provider)
- ⚠ Skin rash (kava dermopathy) with chronic high-dose use
- ⚠ GI discomfort
알려진 상호작용
- ● Alcohol — increased hepatotoxicity risk and CNS depression
- ● Hepatotoxic medications (acetaminophen, statins) — additive liver stress
- ● Benzodiazepines and sedatives — additive CNS depression
- ● CYP450 substrates (2E1, 1A2, 2D6) — kavalactones may inhibit metabolism
- ● Levodopa and dopaminergic drugs — kava may reduce efficacy
일일 최대 섭취 허용량: 250 mg kavalactones/day (European guidelines); limited to 3 months continuous use
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does 카바 help with 과각성 및 인지적 불면증?
Based on 23 studies with 2,043 participants, there is strong evidence from multiple clinical trials that 카바 may support 과각성 및 인지적 불면증 management. Our evidence grade is A (Strong Evidence).
How much 카바 should I take for 과각성 및 인지적 불면증?
Studies have used various dosages. A commonly studied range is 120-250 mg kavalactones/day, 1-2 hrs before bed. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 카바?
Reported side effects may include Drowsiness and reduced coordination, Hepatotoxicity (rare but serious — consult healthcare provider), Skin rash (kava dermopathy) with chronic high-dose use, GI discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 카바 and 과각성 및 인지적 불면증?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 23 peer-reviewed studies with 2,043 total participants. The overall direction of effect is mixed.
Related Evidence
관련 다른 성분: 과각성 및 인지적 불면증
카바 다른 건강 상태에 대한 근거
References
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- [2] William Bleifuss et al.. Am J Emerg Med. 2025. Severe kava withdrawal managed with phenobarbital. doi:10.1016/j.ajem.2025.06.016 PubMed
- [3] Chengguo Xing et al.. BMC Complement Med Ther. 2024. The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a … doi:10.1186/s12906-024-04722-9 PubMed
- [4] Rita B Soares et al.. J Clin Med. 2022. An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. doi:10.3390/jcm11144039 PubMed
- [5] Kanika Verma et al.. Cureus. 2022. The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. doi:10.7759/cureus.28425 PubMed
- [6] Juliana Veloso Ferreira et al.. Nat Prod Res. 2022. Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain. doi:10.1080/14786419.2021.1973459 PubMed
- [7] Deana Goldin et al.. J Psychosoc Nurs Ment Health Serv. 2022. Calm Down With Kava: What Clinicians Need to Know. doi:10.3928/02793695-20220523-02 PubMed
- [8] Ruhi Ali et al.. Comb Chem High Throughput Screen. 2021. Nutraceuticals for Sleep Disorders. doi:10.2174/1386207324666210121111446 PubMed
- [9] Jennifer L Martin et al.. J Clin Sleep Med. 2020. The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … doi:10.5664/jcsm.8486 PubMed
- [10] Pengcheng Wang et al.. Chem Res Toxicol. 2019. Enzymes and Pathways of Kavain Bioactivation and Biotransformation. doi:10.1021/acs.chemrestox.9b00098 PubMed
- [11] Jungyoon Kim et al.. J Med Food. 2018. Natural Products from Single Plants as Sleep Aids: A Systematic Review. doi:10.1089/jmf.2017.4064 PubMed
- [12] Matthew J Leach et al.. Sleep Med Rev. 2015. Herbal medicine for insomnia: A systematic review and meta-analysis. doi:10.1016/j.smrv.2014.12.003 PubMed
- [13] Stephanie Maxine Ross. Holist Nurs Pract. 2014. Psychophytomedicine: an overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. doi:10.1097/HNP.0000000000000040 PubMed
- [14] Anthony Rowe et al.. Adv Pharmacol Sci. 2011. Toxicokinetics of kava. doi:10.1155/2011/326724 PubMed
- [15] Ping Zhou et al.. FASEB J. 2010. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. doi:10.1096/fj.10-163311 PubMed
- [16] David Wheatley. J Psychopharmacol. 2005. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. doi:10.1177/0269881105053309 PubMed
- [17] Bradly P Jacobs et al.. Medicine (Baltimore). 2005. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. doi:10.1097/01.md.0000172299.72364.95 PubMed
- [18] Kazuaki Shinomiya et al.. Psychopharmacology (Berl). 2005. Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. doi:10.1007/s00213-005-2196-4 PubMed
- [19] Keith I Block et al.. Integr Cancer Ther. 2004. Safety and efficacy of herbal sedatives in cancer care. doi:10.1177/1534735404265003 PubMed
- [20] Sheree Cairney et al.. Hum Psychopharmacol. 2003. Saccade and cognitive impairment associated with kava intoxication. doi:10.1002/hup.532 PubMed
- [21] Ka Fai Chung et al.. Gen Hosp Psychiatry. 2002. Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. doi:10.1016/s0163-8343(02)00210-4 PubMed
- [22] D Wheatley. Phytother Res. 2001. Kava and valerian in the treatment of stress-induced insomnia. doi:10.1002/ptr.840 PubMed
- [23] David Wheatley. Hum Psychopharmacol. 2001. Stress-induced insomnia treated with kava and valerian: singly and in combination. doi:10.1002/hup.299 PubMed
- [24] R Süss et al.. Hautarzt. 1996. [Hematogenous contact eczema cause by phytogenic drugs exemplified by kava root extract]. doi:10.1007/s001050050451 PubMed
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