글리신 관련 불면증

Q: Does 글리신 help with 불면증?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that 글리신 may support 불면증 management. Our evidence grade is A (Strong Evidence).

Q: How much 글리신 should I take for 불면증?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of 글리신?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for 글리신 and 불면증?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

총 484,248명의 참여자를 대상으로 한 36건의 연구(메타분석 2건, RCT 6건)에 근거합니다. 36건 중 22건의 연구에서 긍정적인 효과가 나타났습니다.

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결론

Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.

22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
Large evidence base of over 484,000 participants across all study types

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo 효과: None < 0.05

systematic review n=451 Double-blind

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …

Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa vs: Placebo 효과: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week 0.05 (bruxism); < 0.04 (enures

In vitro

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.

Dose: None vs: Placebo 효과: None None

basic science

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …

Dose: Arachis hypogaea L. stems and leaves extract vs: Placebo 효과: None None

randomized controlled trial n=13 1 weeks Double-blind

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …

Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights vs: Placebo 효과: None 0.028

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo 효과: None None

Key Statistics

연구

483763

참여자

↑

Positive

등급

Referenced Papers

Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation … Other

Pharmaceuticals (Basel, Switzerland) 2026

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures. Other

Journal of chemical … 2025 3 인용

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … Review

Children (Basel, Switzerland) 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. Other

Journal of pharmaceutical … 2025

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. RCT

European journal of … 2024 10 인용

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 인용

Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. Other

Human genetics 2023 17 인용

Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. Other

Neurological sciences : … 2023 9 인용

Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats. Other

International journal of … 2023 8 인용

New hybrids based on benzimidazole and diazepine moieties: design, synthesis, characterization, molecular docking studies and their in vitro interactions with … Other

Journal of biomolecular … 2023 3 인용

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial. RCT

Journal of the … 2022 55 인용

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 인용

Metabonomics Study of Ginseng Glycoproteins on Improving Sleep Quality in Mice. Other

BioMed research international 2019 19 인용

Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia. Other

Clinical cancer research … 2018 65 인용

A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia. Other

Leukemia research 2018 35 인용

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 인용

Not a single but multiple populations of GABAergic neurons control sleep. Review

Sleep medicine reviews 2017 99 인용

A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese … RCT

BMC psychiatry 2016 26 인용

Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Case Report

Addictive behaviors 2016 3 인용

Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases. Other

Molecular neurobiology 2016

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Review

Fitoterapia 2015 55 인용

Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Review

Acta biochimica et … 2013 25 인용

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 인용

Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Other

Psychiatry and clinical … 2011 23 인용

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Case Report

Human mutation 2009 136 인용

Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited. Review

Steroids 2009 11 인용

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine. Other

Current drug delivery 2009 1 인용

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Other

Nutritional neuroscience 2008 73 인용

Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series. Other

Journal of medical … 2008 33 인용

GABA and glycine as neurotransmitters: a brief history. Other

British journal of … 2006 351 인용

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. RCT

British journal of … 2005 3 인용

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. Case Report

Neurology 2002 56 인용

Folates: supplemental forms and therapeutic applications. Review

Alternative medicine review … 1998 58 인용

Felbamate pharmacology and use in epilepsy. Review

Clinical neuropharmacology 1994 18 인용

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … RCT

European journal of … 1986 22 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

sleep:: 3 g, 1 hour before bed

상한량: Not established; studied up to 9 g/day

연구에서 사용된 용량

용량	기간	효과	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa	--	Positive	451
None	--	Neutral	--
Arachis hypogaea L. stems and leaves extract	--	Positive	--
15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights	1 weeks	Positive	13
None	3 weeks	Positive	--
not applicable	--	Neutral	17
None	--	Mixed	482730

권장 복용 시간: 1 hour before bed

Safety & Side Effects

보고된 부작용

⚠ Nausea
⚠ Soft stools
⚠ Mild drowsiness

알려진 상호작용

● Clozapine — glycine may reduce effectiveness of this antipsychotic
● Antihypertensives — potential additive blood pressure lowering

일일 최대 섭취 허용량: Not established; studied up to 9 g/day

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 글리신 help with 불면증?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that 글리신 may support 불면증 management. Our evidence grade is A (Strong Evidence).

How much 글리신 should I take for 불면증?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 글리신?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 글리신 and 불면증?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Related Evidence

글리신 다른 건강 상태에 대한 근거

수면 개시 장애 D

한눈에 보기

총 484,248명의 참여자를 대상으로 한 36건의 연구(메타분석 2건, RCT 6건)에 근거합니다. 36건 중 22건의 연구에서 긍정적인 효과가 나타났습니다.

Evidence Strength92%

High confidence

연구 분석

RCT (6)Meta (0)Other (30)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: 불면증

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FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.