Glycine untuk Insomnia

Q: Does Glycine help with Insomnia?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glycine may support Insomnia management. Our evidence grade is A (Strong Evidence).

Q: How much Glycine should I take for Insomnia?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Glycine?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Glycine and Insomnia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Berdasarkan 36 studi (2 meta-analyses, 6 RCTs) dengan 484,248 peserta secara total. 22/36 studi menunjukkan efek positif.

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Kesimpulan

Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.

22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
Large evidence base of over 484,000 participants across all study types

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Efek: None < 0.05

systematic review n=451 Double-blind

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …

Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa vs: Placebo Efek: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week 0.05 (bruxism); < 0.04 (enures

In vitro

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.

Dose: None vs: Placebo Efek: None None

basic science

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …

Dose: Arachis hypogaea L. stems and leaves extract vs: Placebo Efek: None None

randomized controlled trial n=13 1 weeks Double-blind

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …

Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights vs: Placebo Efek: None 0.028

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo Efek: None None

Key Statistics

Studi

483763

Peserta

↑

Positive

Peringkat

Referenced Papers

Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation … Other

Pharmaceuticals (Basel, Switzerland) 2026

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures. Other

Journal of chemical … 2025 3 sitasi

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … Review

Children (Basel, Switzerland) 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. Other

Journal of pharmaceutical … 2025

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. RCT

European journal of … 2024 10 sitasi

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 sitasi

Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. Other

Human genetics 2023 17 sitasi

Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. Other

Neurological sciences : … 2023 9 sitasi

Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats. Other

International journal of … 2023 8 sitasi

New hybrids based on benzimidazole and diazepine moieties: design, synthesis, characterization, molecular docking studies and their in vitro interactions with … Other

Journal of biomolecular … 2023 3 sitasi

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial. RCT

Journal of the … 2022 55 sitasi

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 sitasi

Metabonomics Study of Ginseng Glycoproteins on Improving Sleep Quality in Mice. Other

BioMed research international 2019 19 sitasi

Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia. Other

Clinical cancer research … 2018 65 sitasi

A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia. Other

Leukemia research 2018 35 sitasi

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 sitasi

Not a single but multiple populations of GABAergic neurons control sleep. Review

Sleep medicine reviews 2017 99 sitasi

A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese … RCT

BMC psychiatry 2016 26 sitasi

Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Case Report

Addictive behaviors 2016 3 sitasi

Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases. Other

Molecular neurobiology 2016

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Review

Fitoterapia 2015 55 sitasi

Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Review

Acta biochimica et … 2013 25 sitasi

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 sitasi

Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Other

Psychiatry and clinical … 2011 23 sitasi

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Case Report

Human mutation 2009 136 sitasi

Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited. Review

Steroids 2009 11 sitasi

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine. Other

Current drug delivery 2009 1 sitasi

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Other

Nutritional neuroscience 2008 73 sitasi

Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series. Other

Journal of medical … 2008 33 sitasi

GABA and glycine as neurotransmitters: a brief history. Other

British journal of … 2006 351 sitasi

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. RCT

British journal of … 2005 3 sitasi

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. Case Report

Neurology 2002 56 sitasi

Folates: supplemental forms and therapeutic applications. Review

Alternative medicine review … 1998 58 sitasi

Felbamate pharmacology and use in epilepsy. Review

Clinical neuropharmacology 1994 18 sitasi

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … RCT

European journal of … 1986 22 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

sleep:: 3 g, 1 hour before bed

Batas atas: Not established; studied up to 9 g/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa	--	Positive	451
None	--	Neutral	--
Arachis hypogaea L. stems and leaves extract	--	Positive	--
15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights	1 weeks	Positive	13
None	3 weeks	Positive	--
not applicable	--	Neutral	17
None	--	Mixed	482730

Waktu terbaik diminum: 1 hour before bed

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Nausea
⚠ Soft stools
⚠ Mild drowsiness

Interaksi yang Diketahui

● Clozapine — glycine may reduce effectiveness of this antipsychotic
● Antihypertensives — potential additive blood pressure lowering

Asupan atas yang dapat ditoleransi: Not established; studied up to 9 g/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Glycine help with Insomnia?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glycine may support Insomnia management. Our evidence grade is A (Strong Evidence).

How much Glycine should I take for Insomnia?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glycine?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glycine and Insomnia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Insomnia

Melatonin A Akar Valerian A CBD A Asam Lemak Omega-3 A Tryptophan A Vitamin D A

Glycine untuk kondisi lain

Kesulitan Onset Tidur D

Kesimpulan Singkat

Berdasarkan 36 studi (2 meta-analyses, 6 RCTs) dengan 484,248 peserta secara total. 22/36 studi menunjukkan efek positif.

Evidence Strength92%

High confidence

Rincian Studi

RCT (6)Meta (0)Other (30)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Insomnia

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.