Glicina para Insônia

Q: Does Glicina help with Insônia?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glicina may support Insônia management. Our evidence grade is A (Strong Evidence).

Q: How much Glicina should I take for Insônia?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Glicina?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Glicina and Insônia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Baseado em 36 estudos (2 meta-analyses, 6 RCTs) com 484,248 participantes no total. 22/36 estudos mostram efeitos positivos.

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Conclusão

Glycine is supported by strong evidence as a supplement that may help improve overall sleep quality, with benefits seen in multiple well-designed clinical trials.

22 out of 36 studies show positive effects, with 6 RCTs and 2 meta-analyses
Glycine may promote sleep by lowering core body temperature, a natural sleep trigger
A 2024 RCT showed collagen peptides (glycine-rich) reduced sleep fragmentation
Large evidence base of over 484,000 participants across all study types

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Efeito: None < 0.05

systematic review n=451 Double-blind

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According …

Dose: various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa vs: Placebo Efeito: bruxism: ΔVAS -2.36 vs -1.72; enuresis: median -2.4 nights/week 0.05 (bruxism); < 0.04 (enures

In vitro

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures.

Dose: None vs: Placebo Efeito: None None

basic science

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine …

Dose: Arachis hypogaea L. stems and leaves extract vs: Placebo Efeito: None None

randomized controlled trial n=13 1 weeks Double-blind

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active …

Dose: 15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights vs: Placebo Efeito: None 0.028

animal experimental 3 weeks

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

Dose: None vs: Placebo Efeito: None None

Key Statistics

Estudos

483763

Participantes

↑

Positive

Nota

Referenced Papers

Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation … Other

Pharmaceuticals (Basel, Switzerland) 2026

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP106-145 Aggregation into β-Sheet Structures. Other

Journal of chemical … 2025 3 citações

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based … Review

Children (Basel, Switzerland) 2025

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. Other

Journal of pharmaceutical … 2025

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. RCT

European journal of … 2024 10 citações

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Review

Journal of ethnopharmacology 2024 6 citações

Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. Other

Human genetics 2023 17 citações

Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. Other

Neurological sciences : … 2023 9 citações

Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats. Other

International journal of … 2023 8 citações

New hybrids based on benzimidazole and diazepine moieties: design, synthesis, characterization, molecular docking studies and their in vitro interactions with … Other

Journal of biomolecular … 2023 3 citações

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial. RCT

Journal of the … 2022 55 citações

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. Case Report

Brain sciences 2020 12 citações

Metabonomics Study of Ginseng Glycoproteins on Improving Sleep Quality in Mice. Other

BioMed research international 2019 19 citações

Prospective Clinical Trial of Ixazomib, Dexamethasone, and Rituximab as Primary Therapy in Waldenström Macroglobulinemia. Other

Clinical cancer research … 2018 65 citações

A phase 1/2 study of rigosertib in patients with myelodysplastic syndromes (MDS) and MDS progressed to acute myeloid leukemia. Other

Leukemia research 2018 35 citações

A review of effective herbal medicines in controlling menopausal symptoms. Review

Electronic physician 2017 102 citações

Not a single but multiple populations of GABAergic neurons control sleep. Review

Sleep medicine reviews 2017 99 citações

A double-blind randomized study assessing safety and efficacy following one-year adjunctive treatment with bitopertin, a glycine reuptake inhibitor, in Japanese … RCT

BMC psychiatry 2016 26 citações

Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. Case Report

Addictive behaviors 2016 3 citações

Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases. Other

Molecular neurobiology 2016

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway. Review

Fitoterapia 2015 55 citações

Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Review

Acta biochimica et … 2013 25 citações

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Other

Frontiers in neurology 2012 27 citações

Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Other

Psychiatry and clinical … 2011 23 citações

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Case Report

Human mutation 2009 136 citações

Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues revisited. Review

Steroids 2009 11 citações

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine. Other

Current drug delivery 2009 1 citações

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Other

Nutritional neuroscience 2008 73 citações

Human prion disease with a G114V mutation and epidemiological studies in a Chinese family: a case series. Other

Journal of medical … 2008 33 citações

GABA and glycine as neurotransmitters: a brief history. Other

British journal of … 2006 351 citações

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. RCT

Minerva ginecologica 2006

Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. RCT

British journal of … 2005 3 citações

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease. Case Report

Neurology 2002 56 citações

Folates: supplemental forms and therapeutic applications. Review

Alternative medicine review … 1998 58 citações

Felbamate pharmacology and use in epilepsy. Review

Clinical neuropharmacology 1994 18 citações

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial … RCT

European journal of … 1986 22 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

sleep:: 3 g, 1 hour before bed

Limite superior: Not established; studied up to 9 g/day

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
various homoeopathic remedies (complex homoeopathy, Melissa officinalis 12C, individualised homoeopa	--	Positive	451
None	--	Neutral	--
Arachis hypogaea L. stems and leaves extract	--	Positive	--
15 g/day collagen peptides (glycine-rich) consumed 1 hour before bedtime for 7 nights	1 weeks	Positive	13
None	3 weeks	Positive	--
not applicable	--	Neutral	17
None	--	Mixed	482730

Melhor horário: 1 hour before bed

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Nausea
⚠ Soft stools
⚠ Mild drowsiness

Interações Conhecidas

● Clozapine — glycine may reduce effectiveness of this antipsychotic
● Antihypertensives — potential additive blood pressure lowering

Ingestão máxima tolerável: Not established; studied up to 9 g/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Glicina help with Insônia?

Based on 36 studies with 483,763 participants, there is strong evidence from multiple clinical trials that Glicina may support Insônia management. Our evidence grade is A (Strong Evidence).

How much Glicina should I take for Insônia?

Studies have used various dosages. A commonly studied range is 3 g, 1 hour before bed. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glicina?

Reported side effects may include Nausea, Soft stools, Mild drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glicina and Insônia?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 483,763 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Insônia

Melatonina A Raiz de valeriana A CBD A Ácidos graxos ômega-3 A Triptófano A Vitamina D A

Glicina para outras condições

Dificuldade para Adormecer D

Veredito Rápido

Baseado em 36 estudos (2 meta-analyses, 6 RCTs) com 484,248 participantes no total. 22/36 estudos mostram efeitos positivos.

Evidence Strength92%

High confidence

Detalhamento dos Estudos

RCT (6)Meta (0)Other (30)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Insônia

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.